Understanding construction reform discourses

This is an Accepted Manuscript of an article published by Taylor & Francis in Construction Management and Economics on 8th May 2014, available online: http://wwww.tandfonline.com/10.1080/01446193.2014.909049Attempts to drive change and reform of the UK construction industry have been an ongoing concern for numerous stakeholders, both in government and across industry, for years. The issue is a seemingly perennially topical one which shows little sign of abating. Scholarly analyses of the reform agenda have tended to adopt a Critical Theory perspective. Such an approach, however, lacks a certain nuance and perhaps only reveals one layer of social reality. What is arguably lacking is a more fundamental exposition concerning the historical, social and cultural explanatory forces at play. While it is illuminating to expose vested interests, ideology and power, what has led to the development of various views? How have they come to achieve such high accord in discussions? Drawing on the works of Max Weber, Georg Simmel and Barbara Adam, this paper seeks to develop a broader theoretical lens. It considers the wider socio-cultural structures and forces that influence behaviour, shape and constrain these views. This approach will contribute to a much needed broader philosophical and theoretical debate within the construction management community (and beyond) on the need to better engage with, and understand, the sources influencing the issue of policy formulation and diffusion. © 2014 Taylor & Francis

Deciphering The Labyrinth: The Influence of Georg Simmel on the Sociology of Octavio Paz

Octavio Paz has been known worldwide as a talented poet and essayist, but not as a sociologist. And yet his seminal work, The Labyrinth of Solitude, published in 1950 and containing Paz’s interpretation of Mexican history and identity, arrived at via his analysis of Mexican ‘myths’ or cultural forms, is rich in sociological content – particularly sociology of culture and sociology of knowledge. The author of this article, after noting that very few of the experts on Paz’s work have tried to analyze in a serious and sustained manner its sociological content, has determined not only to decipher Paz’s method but to reveal its strong links to the sociology of form and content produced by the German sociologist and philosopher Georg Simmel. Thus, the main goal of this article is to apply Simmel’s methods to The Labyrinth of Solitude and to thereby (1) shed some light on the sociological aspects of Paz’s seminal work, thus bringing him the credit he deserves as an early Mexican sociologist, and (2) reveal the extent of Simmel’s influence – hitherto ignored or at least very much minimized – upon The Labyrinth

Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation

International audienceChanges in synaptic excitability and reduced brain metabolism are among the earliest detectable alterations associated with the development of Alzheimer's disease (AD). Stimulation of synaptic activity has been shown to be protective in models of AD beta-amyloidosis. Remarkably, deep brain stimulation (DBS) provides beneficial effects in AD patients, and represents an important therapeutic approach against AD and other forms of dementia. While several studies have explored the effect of synaptic activation on beta-amyloid, little is known about Tau protein. In this study, we investigated the effect of synaptic stimulation on Tau pathology and synapses in in vivo and in vitro models of AD and frontotemporal dementia (FTD). We found that chronic DBS or chemically induced synaptic stimulation reduced accumulation of pathological forms of Tau and protected synapses, while chronic inhibition of synaptic activity worsened Tau pathology and caused detrimental effects on pre- and post-synaptic markers, suggesting that synapses are affected. Interestingly, degradation via the proteasomal system was not involved in the reduction of pathological Tau during stimulation. In contrast, chronic synaptic activation promoted clearance of Tau oligomers by autophagosomes and lysosomes. Chronic inhibition of synaptic activity resulted in opposite outcomes, with build-up of Tau oligomers in enlarged auto-lysosomes. Our data indicate that synaptic activity counteracts the negative effects of Tau in AD and FTD by acting on autophagy, providing a rationale for therapeutic use of DBS and synaptic stimulation in tauopathies