647 research outputs found
Evidence for Superfluidity of Ultracold Fermions in an Optical Lattice
The study of superfluid fermion pairs in a periodic potential has important
ramifications for understanding superconductivity in crystalline materials.
Using cold atomic gases, various condensed matter models can be studied in a
highly controllable environment. Weakly repulsive fermions in an optical
lattice could undergo d-wave pairing at low temperatures, a possible mechanism
for high temperature superconductivity in the cuprates. The lattice potential
could also strongly increase the critical temperature for s-wave superfluidity.
Recent experimental advances in the bulk include the observation of fermion
pair condensates and high-temperature superfluidity. Experiments with fermions
and bosonic bound pairs in optical lattices have been reported, but have not
yet addressed superfluid behavior. Here we show that when a condensate of
fermionic atom pairs was released from an optical lattice, distinct
interference peaks appear, implying long range order, a property of a
superfluid. Conceptually, this implies that strong s-wave pairing and
superfluidity have now been established in a lattice potential, where the
transport of atoms occurs by quantum mechanical tunneling and not by simple
propagation. These observations were made for unitarity limited interactions on
both sides of a Feshbach resonance. For larger lattice depths, the coherence
was lost in a reversible manner, possibly due to a superfluid to insulator
transition. Such strongly interacting fermions in an optical lattice can be
used to study a new class of Hamiltonians with interband and atom-molecule
couplings.Comment: accepted for publication in Natur
Repulsively bound atom pairs in an optical lattice
Throughout physics, stable composite objects are usually formed via
attractive forces, which allow the constituents to lower their energy by
binding together. Repulsive forces separate particles in free space. However,
in a structured environment such as a periodic potential and in the absence of
dissipation, stable composite objects can exist even for repulsive
interactions. Here we report on the first observation of such an exotic bound
state, comprised of a pair of ultracold atoms in an optical lattice. Consistent
with our theoretical analysis, these repulsively bound pairs exhibit long
lifetimes, even under collisions with one another. Signatures of the pairs are
also recognised in the characteristic momentum distribution and through
spectroscopic measurements. There is no analogue in traditional condensed
matter systems of such repulsively bound pairs, due to the presence of strong
decay channels. These results exemplify on a new level the strong
correspondence between the optical lattice physics of ultracold bosonic atoms
and the Bose-Hubbard model, a correspondence which is vital for future
applications of these systems to the study of strongly correlated condensed
matter systems and to quantum information.Comment: 5 pages, 4 figure
Direct Observation of the Superfluid Phase Transition in Ultracold Fermi Gases
Water freezes into ice, atomic spins spontaneously align in a magnet, liquid
helium becomes superfluid: Phase transitions are dramatic phenomena. However,
despite the drastic change in the system's behaviour, observing the transition
can sometimes be subtle. The hallmark of Bose-Einstein condensation (BEC) and
superfluidity in trapped, weakly interacting Bose gases is the sudden
appearance of a dense central core inside a thermal cloud. In strongly
interacting gases, such as the recently observed fermionic superfluids, this
clear separation between the superfluid and the normal parts of the cloud is no
longer given. Condensates of fermion pairs could be detected only using
magnetic field sweeps into the weakly interacting regime. The quantitative
description of these sweeps presents a major theoretical challenge. Here we
demonstrate that the superfluid phase transition can be directly observed by
sudden changes in the shape of the clouds, in complete analogy to the case of
weakly interacting Bose gases. By preparing unequal mixtures of the two spin
components involved in the pairing, we greatly enhance the contrast between the
superfluid core and the normal component. Furthermore, the non-interacting
wings of excess atoms serve as a direct and reliable thermometer. Even in the
normal state, strong interactions significantly deform the density profile of
the majority spin component. We show that it is these interactions which drive
the normal-to-superfluid transition at the critical population imbalance of
70(5)%.Comment: 16 pages (incl. Supplemental Material), 5 figure
HEE-GER: a systematic review of German economic evaluations of health care published 1990–2004
BACKGROUND: Studies published in non-English languages are systematically missing in systematic reviews of growth and quality of economic evaluations of health care. The aims of this study were: to characterize German evaluations, published in English or German-language, in terms of various key parameters; to investigate methods to derive quality-of-life weights in cost-utility studies; and to examine changes in study characteristics over the years. METHODS: We conducted a country-specific systematic review of the German and English-language literature of German economic evaluations (assessment of or application to the German health care system) published 1990–2004. Generic and specialized health economic databases were searched. Two independent reviewers verified fulfillment of inclusion criteria and extracted study characteristics. RESULTS: The fulltexts of 730 articles were reviewed of which 283 fulfilled all entry criteria. 32% of included studies were published in German-language. 51% of studies evaluated pharmaceuticals and 63% were cost-effectiveness analyses. Economic appraisals concentrate on few disease categories and important health areas are strongly underrepresented. Declaration of sponsorship was associated with article language (49% English articles vs. 29% German articles, p < 0.001). The methodology used to obtain quality-of-life weights in published cost-utility studies was very diverse, poorly reported and most studies did not use German patients' or community health state valuations. CONCLUSION: Many of the German-language evaluations included in our study are likely to be missing in international reviews and may be systematically different from English-language reviews from Germany. Lack of transparency and adherence to recommended reporting practices constitute a serious problem in German economic evaluations
Novel autoantigens immunogenic in COPD patients
<p>Abstract</p> <p>Background</p> <p>Chronic obstructive pulmonary disease (COPD) is a respiratory inflammatory condition with autoimmune features including IgG autoantibodies. In this study we analyze the complexity of the autoantibody response and reveal the nature of the antigens that are recognized by autoantibodies in COPD patients.</p> <p>Methods</p> <p>An array of 1827 gridded immunogenic peptide clones was established and screened with 17 sera of COPD patients and 60 healthy controls. Protein arrays were evaluated both by visual inspection and a recently developed computer aided image analysis technique. By this computer aided image analysis technique we computed the intensity values for each peptide clone and each serum and calculated the area under the receiver operator characteristics curve (AUC) for each clone and the separation COPD sera versus control sera.</p> <p>Results</p> <p>By visual evaluation we detected 381 peptide clones that reacted with autoantibodies of COPD patients including 17 clones that reacted with more than 60% of the COPD sera and seven clones that reacted with more than 90% of the COPD sera. The comparison of COPD sera and controls by the automated image analysis system identified 212 peptide clones with informative AUC values. By <it>in silico </it>sequence analysis we found an enrichment of sequence motives previously associated with immunogenicity.</p> <p>Conclusion</p> <p>The identification of a rather complex humoral immune response in COPD patients supports the idea of COPD as a disease with strong autoimmune features. The identification of novel immunogenic antigens is a first step towards a better understanding of the autoimmune component of COPD.</p
Debt, economic growth and interest rates: An empirical study of the Swiss case, presenting a new long-term dataset: 1894-2014
Abstract In this paper, relations between public debt, economic growth, and long-term interest rates in Switzerland from 1894 to 2014 are examined. For this purpose, an original long-term dataset on the general gross public debt in Switzerland, namely the aggregation of the Confederation gross debt, the cantons’ gross debts, and the municipal gross debts, was reconstructed. Three different statistical approaches are performed to study relations between this aggregated debt, economic growth, and interest rates. The first consists of the study of correlations between GDP-weighted variables, the second is the study of the correlation between residuals of ARIMA time series models, and the last one studies vector autoregression (VAR) models, allowing us to test Granger causalities between variables. Every approach is performed on the whole time period but also on boom phases and recession phases independently. All the results suggest that the public debt during this period in Switzerland did not have a negative impact on economic growth and did not raise long-term interest rates
A quantitative description of the transition between intuitive altruism and rational deliberation in iterated Prisoner's Dilemma experiments
What is intuitive: pro-social or anti-social behaviour? To answer this
fundamental question, recent studies analyse decision times in game theory
experiments under the assumption that intuitive decisions are fast and that
deliberation is slow. These analyses keep track of the average time taken to
make decisions under different conditions. Lacking any knowledge of the
underlying dynamics, such simplistic approach might however lead to erroneous
interpretations. Here we model the cognitive basis of strategic cooperative
decision making using the Drift Diffusion Model to discern between deliberation
and intuition and describe the evolution of the decision making in iterated
Prisoner's Dilemma experiments. We find that, although initially people's
intuitive decision is to cooperate, rational deliberation quickly becomes
dominant over an initial intuitive bias towards cooperation, which is fostered
by positive interactions as much as frustrated by a negative one. However, this
initial pro-social tendency is resilient, as after a pause it resets to the
same initial value. These results illustrate the new insight that can be
achieved thanks to a quantitative modelling of human behavior
A Mott insulator of fermionic atoms in an optical lattice
In a solid material strong interactions between the electrons can lead to
surprising properties. A prime example is the Mott insulator, where the
suppression of conductivity is a result of interactions and not the consequence
of a filled Bloch band. The proximity to the Mott insulating phase in fermionic
systems is the origin for many intriguing phenomena in condensed matter
physics, most notably high-temperature superconductivity. Therefore it is
highly desirable to use the novel experimental tools developed in atomic
physics to access this regime. Indeed, the Hubbard model, which encompasses the
essential physics of the Mott insulator, also applies to quantum gases trapped
in an optical lattice. However, the Mott insulating regime has so far been
reached only with a gas of bosons, lacking the rich and peculiar nature of
fermions. Here we report on the formation of a Mott insulator of a repulsively
interacting two-component Fermi gas in an optical lattice. It is signalled by
three features: a drastic suppression of doubly occupied lattice sites, a
strong reduction of the compressibility inferred from the response of double
occupancy to atom number increase, and the appearance of a gapped mode in the
excitation spectrum. Direct control of the interaction strength allows us to
compare the Mott insulating and the non-interacting regime without changing
tunnel-coupling or confinement. Our results pave the way for further studies of
the Mott insulator, including spin ordering and ultimately the question of
d-wave superfluidity.Comment: 6 pages, 4 figure
Evaluation of a blocking ELISA for the detection of antibodies against Lawsonia intracellularis in pig sera
<p>Abstract</p> <p>Background</p> <p><it>Lawsonia intracellularis </it>is a common cause of chronic diarrhoea and poor performance in young growing pigs. Diagnosis of this obligate intracellular bacterium is based on the demonstration of the microbe or microbial DNA in tissue specimens or faecal samples, or the demonstration of <it>L. intracellularis</it>-specific antibodies in sera. The aim of the present study was to evaluate a blocking ELISA in the detection of serum antibodies to <it>L. intracellularis</it>, by comparison to the previously widely used immunofluorescent antibody test (IFAT).</p> <p>Methods</p> <p>Sera were collected from 176 pigs aged 8-12 weeks originating from 24 herds with or without problems with diarrhoea and poor performance in young growing pigs. Sera were analyzed by the blocking ELISA and by IFAT. Bayesian modelling techniques were used to account for the absence of a gold standard test and the results of the blocking ELISA was modelled against the IFAT test with a "2 dependent tests, 2 populations, no gold standard" model.</p> <p>Results</p> <p>At the finally selected cut-off value of percent inhibition (PI) 35, the diagnostic sensitivity of the blocking ELISA was 72% and the diagnostic specificity was 93%. The positive predictive value was 0.82 and the negative predictive value was 0.89, at the observed prevalence of 33.5%.</p> <p>Conclusion</p> <p>The sensitivity and specificity as evaluated by Bayesian statistic techniques differed from that previously reported. Properties of diagnostic tests may well vary between countries, laboratories and among populations of animals. In the absence of a true gold standard, the importance of validating new methods by appropriate statistical methods and with respect to the target population must be emphasized.</p
Plasmodium falciparum Malaria Endemicity in Indonesia in 2010
BACKGROUND: Malaria control programs require a detailed understanding of the contemporary spatial distribution of infection risk to efficiently allocate resources. We used model based geostatistics (MBG) techniques to generate a contemporary map of Plasmodium falciparum malaria risk in Indonesia in 2010. METHODS: Plasmodium falciparum Annual Parasite Incidence (PfAPI) data (2006-2008) were used to map limits of P. falciparum transmission. A total of 2,581 community blood surveys of P. falciparum parasite rate (PfPR) were identified (1985-2009). After quality control, 2,516 were included into a national database of age-standardized 2-10 year old PfPR data (PfPR(2-10)) for endemicity mapping. A Bayesian MBG procedure was used to create a predicted surface of PfPR(2-10) endemicity with uncertainty estimates. Population at risk estimates were derived with reference to a 2010 human population count surface. RESULTS: We estimate 132.8 million people in Indonesia, lived at risk of P. falciparum transmission in 2010. Of these, 70.3% inhabited areas of unstable transmission and 29.7% in stable transmission. Among those exposed to stable risk, the vast majority were at low risk (93.39%) with the reminder at intermediate (6.6%) and high risk (0.01%). More people in western Indonesia lived in unstable rather than stable transmission zones. In contrast, fewer people in eastern Indonesia lived in unstable versus stable transmission areas. CONCLUSION: While further feasibility assessments will be required, the immediate prospects for sustained control are good across much of the archipelago and medium term plans to transition to the pre-elimination phase are not unrealistic for P. falciparum. Endemicity in areas of Papua will clearly present the greatest challenge. This P. falciparum endemicity map allows malaria control agencies and their partners to comprehensively assess the region-specific prospects for reaching pre-elimination, monitor and evaluate the effectiveness of future strategies against this 2010 baseline and ultimately improve their evidence-based malaria control strategies
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