27 research outputs found
Participation of older newly-diagnosed cancer patients in an observational prospective pilot study: an example of recruitment and retention
<p>Abstract</p> <p>Background</p> <p>There have been few prospective observational studies which recruited older newly-diagnosed cancer patients, and of these only some have reported information on the number needed to screen to recruit their study sample, and the number and reasons for refusal and drop-out. This paper reports on strategies to recruit older newly-diagnosed cancer patients prior to treatment into an observational prospective pilot study and to retain them during a six-month period.</p> <p>Methods</p> <p>Medical charts of all patients in the Segal Cancer Centre aged 65 and over were screened and evaluated for inclusion. Several strategies to facilitate recruitment and retention were implemented. Reasons for exclusion, refusal and loss to follow-up were recorded. Descriptive statistics were used to report the reasons for refusal and loss to follow-up. A non-response analysis using chi-square tests and t-tests was conducted to compare respondents to those who refused to participate and to compare those who completed the study to those who were lost to follow-up. A feedback form with open-ended questions was administered following the last interview to obtain patient's opinions on the length of the interviews and conduct of this pilot study.</p> <p>Results</p> <p>3060 medical charts were screened and 156 eligible patients were identified. Of these 112 patients participated for a response rate of 72%. Reasons for refusal were: feeling too anxious (40%), not interested (25%), no time (12.5%), too sick (5%) or too healthy (5%) or other reasons (5%). Ninety-one patients participated in the six-month follow-up (retention 81.3%), seven patients refused follow-up (6.2%) and fourteen patients died (12.5%) during the course of the study. The median time to conduct the baseline interview was 45 minutes and 57% of baseline interviews were conducted at home. Most patients enjoyed participation and only five felt that the interviews were too long.</p> <p>Conclusion</p> <p>It was feasible to recruit newly-diagnosed cancer patients prior to treatment although it required considerable time and effort. Once patients were included, the retention rate was high despite the fact that most were undergoing active cancer treatment.</p
Fossil skulls reveal that blood flow rate to the brain increased faster than brain volume during human evolution
Does supplementation of contrast MR imaging with thallium-201 brain SPECT improve differentiation between benign and malignant ring-like contrast-enhanced cerebral lesions?
Diagnosis of pediatric multiple sclerosis initially presenting with tumefactive demyelinating lesion using 1H-magnetic resonance spectroscopy
Basal Encephalocele Associated With Hypoplasia of the Internal Carotid Artery -Case Report-
Effectiveness of Family and Caregiver Interventions on Patient Outcomes in Adults with Cancer: A Systematic Review
Coping with physical and psychological symptoms: a qualitative study of advanced lung cancer patients and their family caregivers
Head Injuries
Traumatic brain injuries (TBIs) are the leading cause of mortality and morbidity in patients younger than 40 years, affecting 1.7 million people every year in the USA. They are responsible for one-third of all injury-related deaths, whereas patients who survive may develop severe debilitating long-term sequelae.
They consist of a wide spectrum of diseases, defined as a whole as an “alteration in brain function, or other evidence of brain pathology, caused by an external force.” The causes may vary depending on patient’s age: abuse traumas are most commonly observed in infants, while traumatic and sports-related injuries are seen in toddlers and children. Motor vehicle accidents involve most commonly young adults, whereas the elderly population is more prone to accidental falls.
TBIs are clinically divided into minor, mild, moderate, and severe traumas by using the Glasgow Coma Scale (GCS), the most commonly used grading scale to evaluate the entity of head injuries within the first 48 h, which aims to provide a uniform approach to the clinical assessment of patients involved in acute head traumas.
GCS is the sum of three components which are eye opening, motor response, and verbal response; a minor trauma has a GCS = 15; mild, GCS > 13; moderate, GCS 9–12; and severe, GCS < 8.
An additional TBI clinical classification is provided by the Brain Injury Interdisciplinary Special Interest Group of the American Congress of Rehabilitation Medicine, based on the loss of consciousness, loss of memory for events
occurred immediately before or after trauma, changes in mental status, and focal neurologic deficits. According to this classification, a mild trauma is defined as a physiologically disruption of brain functions, evaluated by the presence of
one of the previous described criteria; additional findings are no abnormalities on computed tomography (CT) scan, GCS > 12, no surgical lesions, and length of hospital recovery less than 48 h. Moderate trauma is defined as a GCS of
9–12, hospital recovery of at least 48 h, surgical intracranial lesions, and positive CT scan findings.
Severe traumas are evident at the moment of clinical presentation.
Chronologically, TBIs are divided into primary (injuries occurring at the time of impact) and secondary lesions (lesions occurring after the initial injury, i.e., cerebral herniation, swelling, ischemia, infection, hydrocephalus), resulting from complication of physiological response to injury. Secondary injuries are potentially preventable by stabilizing the patient, by monitoring vital parameters, and, in some cases, by performing decompressive hemicraniectomy.
Other classifications are based on the mechanism of injury (open or blunt trauma) and on the location, dividing them into intra-axial lesions (cortical contusions, diffuse axonal injury, intracerebral hematoma) and extra-axial lesions (subdural, epidural, subarachnoid, and intraventricular hematomas).
Given these data, it is easy to understand the significative role of imaging in this clinical setting, since its goals are to identify treatable lesions, assist to prevent secondary damage, and provide prognostic information.
In this chapter we aim to review the most commonly encountered and severe brain injuries and their complications