26 research outputs found

    New insights into the genetic etiology of Alzheimer's disease and related dementias

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    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

    Creating Objects in the Flexible Authorization Framework

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    Access control is a crucial concern to build secure IT systems and, more specifically, to protect the confidentiality of information. However, access control is necessary, but not sufficient. Actually, IT systems can manipulate data to provide services to users. The results of a data processing may disclose information concerning the objects used in the data processing itself. Therefore, the control of information flow results fundamental to guarantee data protection. In the last years many information flow control models have been proposed. However, these frameworks mainly focus on the detection and prevention of improper information leaks and do not provide support for the dynamical creation of new objects. In thi
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