ICTV Virus Taxonomy Profile:Coronaviridae 2023

The family Coronaviridae includes viruses with positive-sense RNA genomes of 22-36 kb that are expressed through a nested set of 3' co-terminal subgenomic mRNAs. Members of the subfamily Orthocoronavirinae are characterized by 80-160 nm diameter, enveloped virions with spike projections. The orthocoronaviruses, severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome-related coronavirus are extremely pathogenic for humans and in the last two decades have been responsible for the SARS and MERS epidemics. Another orthocoronavirus, severe acute respiratory syndrome coronavirus 2, was responsible for the recent global COVID-19 pandemic. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Coronaviridae which is available at www.ictv.global/report/coronaviridae.</p

Identifying the Independent Inertial Parameter Space of Robot Manipulators

This paper presents a new approach to the problem of finding the minimum number of inertial parameters of robot manipulator dynamic equations of motion. Based upon the energy difference equation, it is equally applica ble to serial link manipulators as well as graph structured manipulators. The method is conceptually simple, compu tationally efficient, and easy to implement. In particular, the manipulator kinematics and the joint positions and velocities are the only inputs to the algorithm. Applica tions to a serial link and a graph structured manipulator are illustrated.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67982/2/10.1177_027836499101000606.pd

Testing non-uniform k-wise independent distributions over product spaces (extended abstract)

A distribution D over Σ1× ⋯ ×Σ n is called (non-uniform) k-wise independent if for any set of k indices {i 1, ..., i k } and for any z1zki1ik, PrXD[Xi1Xik=z1zk]=PrXD[Xi1=z1]PrXD[Xik=zk]. We study the problem of testing (non-uniform) k-wise independent distributions over product spaces. For the uniform case we show an upper bound on the distance between a distribution D from the set of k-wise independent distributions in terms of the sum of Fourier coefficients of D at vectors of weight at most k. Such a bound was previously known only for the binary field. For the non-uniform case, we give a new characterization of distributions being k-wise independent and further show that such a characterization is robust. These greatly generalize the results of Alon et al. [1] on uniform k-wise independence over the binary field to non-uniform k-wise independence over product spaces. Our results yield natural testing algorithms for k-wise independence with time and sample complexity sublinear in terms of the support size when k is a constant. The main technical tools employed include discrete Fourier transforms and the theory of linear systems of congruences.National Science Foundation (U.S.) (NSF grant 0514771)National Science Foundation (U.S.) (grant 0728645)National Science Foundation (U.S.) (Grant 0732334)Marie Curie International Reintegration Grants (Grant PIRG03-GA-2008-231077)Israel Science Foundation (Grant 1147/09)Israel Science Foundation (Grant 1675/09)Massachusetts Institute of Technology (Akamai Presidential Fellowship

Branch-and-lift algorithm for deterministic global optimization in nonlinear optimal control

This paper presents a branch-and-lift algorithm for solving optimal control problems with smooth nonlinear dynamics and potentially nonconvex objective and constraint functionals to guaranteed global optimality. This algorithm features a direct sequential method and builds upon a generic, spatial branch-and-bound algorithm. A new operation, called lifting, is introduced, which refines the control parameterization via a Gram-Schmidt orthogonalization process, while simultaneously eliminating control subregions that are either infeasible or that provably cannot contain any global optima. Conditions are given under which the image of the control parameterization error in the state space contracts exponentially as the parameterization order is increased, thereby making the lifting operation efficient. A computational technique based on ellipsoidal calculus is also developed that satisfies these conditions. The practical applicability of branch-and-lift is illustrated in a numerical example. © 2013 Springer Science+Business Media New York

Heat transfer research and power cycle transient modeling

Fine axial flutes enhance heat transfer in vertical shell-and-tube exchangers with water inside the tubes and ammonia evaporating or condensing in layer flow on the shell side. Single-tube experiments with R-11 and ammonia indicate local shell-side coefficients 3 to 5 times those for corresponding smooth tubes. Single-tube experiments with water indicate that at moderate velocities the tube-side coefficients are enhanced by a factor equal to the ratio of fluted-to-smooth surface areas while the fluid friction is similarly increased. The experimental data are transformed into mean individual coefficients for ammonia and water. Overall coefficients for a particular case are presented to illustrate the efficacy of enhancement by flutes on one or both sides of the heat transfer surface. Means are described for using emerging data to predict the static and dynamic behavior of the power cycle and the interactions of components throughout the complete power plant