63 research outputs found
Progress Report on the Fluorox Process for April 30, 1957-January 14, 1958
Get PDFProgress in the Fluorox program is reported. The chemical reaction of primary interest in the Fluorox program is the oxidation of UF/sub 4/ with O/sub 2/, 2UF/sub 4/ + O/sub 2/ = UO/sub 2/F/sub 2/ + UF/sub 6/; however, to study this process at higher temperatures, the thermal decomposition of UO/sub 2/F/sub 2/, 3UO/sub 2/F/sub 2/ = 2/3 U/sub 3 /O/sub 8/ + UF/sub 6/ + 1/3 O/sub 2/, is being investigated by thermogravimetric methods in the temperature range 750 to 900 deg C. A fluidized bed reactor and a flame reactor have been used successfully to perform the continuous oxidation of UF/sub 4/ with O/sub 2/. The 3-in. fluidized bed reactor was operated up to 825 deg C on both a continuous and batch basis while the flame reactor was used to continuously react finely divided UF/sub 4/ with O/sub 2/ in a CO-O/sub 2/ flame at temperatures greater than 1200 deg C. (auth
A pilot ASKAP survey of radio transient events in the region around the intermittent pulsar PSR J1107-5907
Get PDFNew insights into the genetic etiology of Alzheimer's disease and related dementias
Get PDFCharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
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