Reconstructing a cepheid light curve with Fourier techniques. I. The Fourier expansion and interrelations

Fourier decomposition is a well-established technique used in the study of stellar pulsation. However, the quality of reconstructed light curves using this method is reduced when the observed data have uneven phase coverage. We use simulated annealing techniques together with Fourier decomposition to improve the quality of the Fourier decomposition for many Optical Gravitational Lensing Experiment LMC fundamental-mode Cepheids. This method restricts the range that Fourier amplitudes can take. The ranges are specified by well-sampled Cepheids in the Galaxy and Magellanic Clouds. We also apply this method to reconstructing Cepheid light curves observed by the Hubble Space Telescope (HST). These typically consist of 12 V-band and four I-band points. We employ a direct Fourier fit to the 12 V-band points using the simulated annealing method mentioned above and explicitly derive and use Fourier interrelations to reconstruct the I-band light curve. We discuss advantages and drawbacks of this method when applied to HST Cepheid data over existing template methods. Application of this method to reconstruct the light curves of Cepheids observed in NGC 4258 shows that the derived Cepheid distance (mu(0) = 29.38 +/- 0.06 mag, random error) is consistent with its geometrical distance (mu(0) = 29.28 +/- 0.09 mag) derived from observations of its water maser

Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes

Cladosporium sphaerospermum, a dematiaceous saprophytic fungus commonly found in diverse environments, has been reported to cause allergy and other occasional diseases in humans. However, its basic biology and genetic information are largely unexplored. A clinical isolate C. sphaerospermum genome, UM 843, was re-sequenced and combined with previously generated sequences to form a model 26.89 Mb genome containing 9,652 predicted genes. Functional annotation on predicted genes suggests the ability of this fungus to degrade carbohydrate and protein complexes. Several putative peptidases responsible for lung tissue hydrolysis were identified. These genes shared high similarity with the Aspergillus peptidases. The UM 843 genome encodes a wide array of proteins involved in the biosynthesis of melanin, siderophores, cladosins and survival in high salinity environment. In addition, a total of 28 genes were predicted to be associated with allergy. Orthologous gene analysis together with 22 other Dothideomycetes showed genes uniquely present in UM 843 that encode four class 1 hydrophobins which may be allergens specific to Cladosporium. The mRNA of these hydrophobins were detected by RT-PCR. The genomic analysis of UM 843 contributes to the understanding of the biology and allergenicity of this widely-prevalent species

Genome sequence of an unclassified pleosporales species isolated from human nasopharyngeal aspirate

Pleosporales is the largest order in the fungal class Dothideomycetes. We report the 36,814,818-bp draft genome sequence and gene annotation of UM1110, a Pleosporales isolate associated with unclassified genera that is potentially a new fungal species. Analysis of the genome sequence led to the finding of genes associated with fungal adhesive proteins, secreted proteases, allergens, and pseudohyphal development

Draft Genome Sequence of Daldinia eschscholzii isolated from blood culture

Daldinia eschscholzii is an invasive endophyte that is most commonly found in plant tissues rich in secondary metabolites. We report the draft genome sequence of D. eschscholzii isolated from blood culture. The draft genome is 35,494,957 bp in length, with 42,898,665 reads, 61,449 contigs, and a G+C content of 46.8. The genome was found to contain a high abundance of genes associated with plant cell wall degradation enzymes, mycotoxin production, and antifungal drug resistance

Sequencing of Cladosporium sphaerospermum, a Dematiaceous Fungus isolated from blood culture

Cladosporium sphaerospermum is one of the most widely distributed allergens causing serious problems in patients with respiratory tract disease. We report the 26,644,473-bp draft genome sequence and gene annotation of C. sphaerospermum UM843. Analysis of the genome sequence led to the finding of genes associated with C. sphaerospermum's melanin biosynthesis, allergens, and antifungal drug resistance

Whole-exome sequencing of breast cancer, malignant peripheral nerve sheath tumor and neurofibroma from a patient with neurofibromatosis type 1

10.1002/cam4.551Cancer Medicine4121871-187

Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma

10.1038/s41408-018-0149-5Blood Cancer Journal81111

65 YEARS OF THE DOUBLE HELIX Genetics informs precision practice in the diagnosis and management of pheochromocytoma

Genome Instability and Cance