An event abstraction layer for the integration of geosensor data

Time series of observations reflect the status of environmental properties. Variations in these properties can be considered as events when they potentially affect the stability of the monitored environment. Organisations dedicated to analyse environmental change use institutionalised descriptions of events to define the observable conditions under which events happen. This also applies to the methods used to classify and model changes in environmental monitoring. The heterogeneity of representations often causes interoperability problems when such communities exchange geospatial information. To enhance interoperability among diverse communities, it is required to develop models that do not restrict the representation of events, but allow integrating different perspectives on changes in the environment. The goal of the Event Abstraction Layer is to facilitate the analysis and integration of geosensor data by inferring events from time series of observations. For the analysis of geosensor data, we use event processing to detect event patterns in time series of observations. Spatio-temporal properties of the event are inferred from the geosensor location and the observation timestamps. For the data integration, we represent event-related information extracted from multiples sources under a common event model. Additionally, domain knowledge is modelled in a multilevel ontology structure. © 2014 Taylor & Francis

Composition, thickness, and homogeneity of the coating of core shell nanoparticles possibilities, limits, and challenges of X ray photoelectron spectroscopy

Core–shell nanoparticles have attracted much attention in recent years due to their unique properties and their increasing importance in many technological and consumer products. However, the chemistry of nanoparticles is still rarely investigated in comparison to their size and morphology. In this review, the possibilities, limits, and challenges of X-ray photoelectron spectroscopy (XPS) for obtaining more insights into the composition, thickness, and homogeneity of nanoparticle coatings are discussed with four examples: CdSe/CdS quantum dots with a thick coating and a small core; NaYF(4)-based upconverting nanoparticles with a large Yb-doped core and a thin Er-doped coating; and two types of polymer nanoparticles with a poly(tetrafluoroethylene) core with either a poly(methyl methacrylate) or polystyrene coating. Different approaches for calculating the thickness of the coating are presented, like a simple numerical modelling or a more complex simulation of the photoelectron peaks. Additionally, modelling of the XPS background for the investigation of coating is discussed. Furthermore, the new possibilities to measure with varying excitation energies or with hard-energy X-ray sources (hard-energy X-ray photoelectron spectroscopy) are described. A discussion about the sources of uncertainty for the determination of the thickness of the coating completes this review. [Figure: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00216-022-04057-9

Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection.

Bone and joint infections (BJI) are one of the most difficult-to-treat bacterial infection, especially in the era of antimicrobial resistance. Lytic bacteriophages (phages for short) are natural viruses that can selectively target and kill bacteria. They are considered to have a high therapeutic potential for the treatment of severe bacterial infections and especially BJI, as they also target biofilms. Here we report on the management of a patient with a pandrug-resistant Pseudomonas aeruginosa spinal abscess who was treated with surgery and a personalized combination of phage therapy that was added to antibiotics. As the infecting P. aeruginosa strain was resistant to the phages developed by private companies that were contacted, we set up a unique European academic collaboration to find, produce and administer a personalized phage cocktail to the patient in due time. After two surgeries, despite bacterial persistence with expression of small colony variants, the patient healed with local and intravenous injections of purified phages as adjuvant therapy