Surface wave control for large arrays of microwave kinetic inductance detectors

Large ultra-sensitive detector arrays are needed for present and future observatories for far infra-red, submillimeter wave (THz), and millimeter wave astronomy. With increasing array size, it is increasingly important to control stray radiation inside the detector chips themselves, the surface wave. We demonstrate this effect with focal plane arrays of 880 lens-antenna coupled Microwave Kinetic Inductance Detectors (MKIDs). Presented here are near field measurements of the MKID optical response versus the position on the array of a reimaged optical source. We demonstrate that the optical response of a detector in these arrays saturates off-pixel at the $\sim-30$ dB level compared to the peak pixel response. The result is that the power detected from a point source at the pixel position is almost identical to the stray response integrated over the chip area. With such a contribution, it would be impossible to measure extended sources, while the point source sensitivity is degraded due to an increase of the stray loading. However, we show that by incorporating an on-chip stray light absorber, the surface wave contribution is reduced by a factor $>$10. With the on-chip stray light absorber the point source response is close to simulations down to the $\sim-35$ dB level, the simulation based on an ideal Gaussian illumination of the optics. In addition, as a crosscheck we show that the extended source response of a single pixel in the array with the absorbing grid is in agreement with the integral of the point source measurements.Comment: accepted for publication in IEEE Transactions on Terahertz Science and Technolog

Exploration of PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis.

Radiomics is an emerging technology for imaging biomarker discovery and disease-specific personalized treatment management. This paper aims to determine the benefit of using multi-modality radiomics data from PET and MR images in the characterization breast cancer phenotype and prognosis. Eighty-four features were extracted from PET and MR images of 113 breast cancer patients. Unsupervised clustering based on PET and MRI radiomic features created three subgroups. These derived subgroups were statistically significantly associated with tumor grade (p = 2.0 × 10-6), tumor overall stage (p = 0.037), breast cancer subtypes (p = 0.0085), and disease recurrence status (p = 0.0053). The PET-derived first-order statistics and gray level co-occurrence matrix (GLCM) textural features were discriminative of breast cancer tumor grade, which was confirmed by the results of L2-regularization logistic regression (with repeated nested cross-validation) with an estimated area under the receiver operating characteristic curve (AUC) of 0.76 (95% confidence interval (CI) = [0.62, 0.83]). The results of ElasticNet logistic regression indicated that PET and MR radiomics distinguished recurrence-free survival, with a mean AUC of 0.75 (95% CI = [0.62, 0.88]) and 0.68 (95% CI = [0.58, 0.81]) for 1 and 2 years, respectively. The MRI-derived GLCM inverse difference moment normalized (IDMN) and the PET-derived GLCM cluster prominence were among the key features in the predictive models for recurrence-free survival. In conclusion, radiomic features from PET and MR images could be helpful in deciphering breast cancer phenotypes and may have potential as imaging biomarkers for prediction of breast cancer recurrence-free survival

Eliminating stray radiation inside large area imaging arrays

With increasing array size, it is increasingly important to control stray radiation inside the detector chips themselves. We demonstrate this effect with focal plane arrays of absorber coupled Lumped Element microwave Kinetic Inductance Detectors (LEKIDs) and lens-antenna coupled distributed quarter wavelength Microwave Kinetic Inductance Detectors (MKIDs). In these arrays the response from a point source at the pixel position is at a similar level to the stray response integrated over the entire chip area. For the antenna coupled arrays, we show that this effect can be suppressed by incorporating an on-chip stray light absorber. A similar method should be possible with the LEKID array, especially when they are lens coupled.Comment: arXiv admin note: substantial text overlap with arXiv:1707.0214

C21orf57 is a human homologue of bacterial YbeY proteins

The product of the human C21orf57 (huYBEY) gene is predicted to be a homologue of the highly conserved YbeY proteins found in nearly all bacteria. We show that, like its bacterial and chloroplast counterparts, the HuYbeY protein is an RNase and that it retains sufficient function in common with bacterial YbeY proteins to partially suppress numerous aspects of the complex phenotype of an Escherichia coli ΔybeY mutant. Expression of HuYbeY in Saccharomyces cerevisiae, which lacks a YbeY homologue, results in a severe growth phenotype. This observation suggests that the function of HuYbeY in human cells is likely regulated through specific interactions with partner proteins similarly to the way YbeY is regulated in bacteria.National Institutes of Health (U.S.) (Grant GM31010)National Institutes of Health (U.S.) (Grant GM17151

A Case study on Utilization of Common Service Centre among the General Public

Common Service Centres (CSCs) form a part of the National e-Governance Plan envisioned in providing Government services to the citizens at their doorstep at an affordable cost, and in a sustainable manner. The CSCs are run by Village Level Entrepreneurs (VLEs) as a component of Public-Private Partnership (PPP) model. (Shadrach and Sharma, 2013). Timely delivery of services through CSC has made life easier for both people and government departments and has increased its efficiency. There are a total of 34 Common Service Centres in Coimbatore district. Various Government and Business- to Consumer services like Aadhaar, Telecom services are provided at an affordable cost through CSC. A study was carried out in one representative CSC, drawn as a case, in Kalveerampalayam, Coimbatore. It was conducted as an ex-post facto research study and percentage analysis was used to analyze the data collected. Three-fourth (76.7%) of the respondents were found to have medium level of utilization of various services provided by the CSC, with Aadhaar being the most used (63%) service. It was prevalent mostly among educated and high-income category of people

Improved control strategy of DFIG-based wind turbines using direct torque and direct power control techniques

This paper presents different control strategies for a variable-speed wind energy conversion system (WECS), based on a doubly fed induction generator. Direct Torque Control (DTC) with Space-Vector Modulation is used on the rotor side converter. This control method is known to reduce the fluctuations of the torque and flux at low speeds in contrast to the classical DTC, where the frequency of switching is uncontrollable. The reference for torque is obtained from the maximum power point tracking technique of the wind turbine. For the grid-side converter, a fuzzy direct power control is proposed for the control of the instantaneous active and reactive power. Simulation results of the WECS are presented to compare the performance of the proposed and classical control approaches.Peer reviewedFinal Accepted Versio

The Effect of Pre-Injury Anti-Platelet Therapy on the Development of Complications in Isolated Blunt Chest Wall Trauma: A Retrospective Study

INTRODUCTION: The difficulties in the management of the blunt chest wall trauma patient in the Emergency Department due to the development of late complications are well recognised in the literature. Pre-injury anti-platelet therapy has been previously investigated as a risk factor for poor outcomes following traumatic head injury, but not in the blunt chest wall trauma patient cohort. The aim of this study was to investigate pre-injury anti-platelet therapy as a risk factor for the development of complications in the recovery phase following blunt chest wall trauma. METHODS: A retrospective study was completed in which the medical notes were analysed of all blunt chest wall trauma patients presenting to a large trauma centre in Wales in 2012 and 2013. Using univariate and multivariable logistic regression analysis, pre-injury platelet therapy was investigated as a risk factor for the development of complications following blunt chest wall trauma. Previously identified risk factors were included in the analysis to address the influence of confounding. RESULTS: A total of 1303 isolated blunt chest wall trauma patients presented to the ED in Morriston Hospital in 2012 and 2013 with complications recorded in 144 patients (11%). On multi-variable analysis, pre-injury anti-platelet therapy was found to be a significant risk factor for the development of complications following isolated blunt chest wall trauma (odds ratio: 16.9; 95% confidence intervals: 8.2-35.2). As in previous studies patient age, number of rib fractures, chronic lung disease and pre-injury anti-coagulant use were also found to be significant risk factors. CONCLUSIONS: Pre-injury anti-platelet therapy is being increasingly used as a first line treatment for a number of conditions and there is a concurrent increase in trauma in the elderly population. Pre-injury anti-platelet therapy should be considered as a risk factor for the development of complications by clinicians managing blunt chest wall trauma

Photoelectrochemical Conversion of Carbon Dioxide (CO2) into Fuels and Value-Added Products /

The conversion of carbon dioxide (CO2) into fuels and value-added products is one of the most significant inventions to address the global warming and energy needs. Photoelectrochemical (PEC) CO2 conversion can be considered as an artificial photosynthesis technique that produces formate, formaldehyde, formic acid, methane, methanol,ethanol, etc. Recent advances in electrode materials, mechanisms, kinetics, thermodynamics, and reactor designs of PEC CO2 conversion have been comprehensively reviewed in this article. The adsorption and activation of CO2/intermediates at the electrode surface are the key steps for improving the kinetics of CO2 conversion. PEC efficiency could be upgraded through the utilization of 2D/3D materials, plasmonic metals, carbon-based catalysts, porous nanostructures, metal−organic frameworks, molecular catalysts, and biological molecules. The defect engineered (by cation/anion vacancy, crystal distortion, pits, and creation of oxygen vacancies) 2D/3D materials, Z-scheme heterojunctions, bioelectrodes, and tandem photovoltaic−PEC reactors are suitable options to enhance the efficiency at low external bias.ye