RXJ0806.3+1527: a double degenerate binary with the shortest known orbital period (321s)

We carried out optical observations of the field of the X-ray pulsator RXJ0806.3+1527. A blue V=21.1 star was found to be the only object consistent with the X-ray position. VLT FORS spectra revealed a blue continuum with no intrinsic absorption lines. Broad (v~1500 km/s), low equivalent width (about -1/-6A) emission lines from the HeII Pickering series were clearly detected. B, V and R time-resolved photometry revealed the presence of about 15% pulsations at the 321s X-ray period, confirming the identification. These findings, together with the period stability and absence of any additional modulation in the 1min-5hr period range, argue in favour of the orbital interpretation of the 321s pulsations. The most likely scenario is thus that RXJ0806.3+1527 is a double degenerate system of the AM CVn class. This would make RXJ0806.3+1527 the shortest orbital period binary currently known and one of the best candidates for gravitational wave detection.Comment: Accepted for publication on A&A Letter

Twenty-four hours secretion pattern of serum estradiol in healthy prepubertal and pubertal boys as determined by a validated ultra-sensitive extraction RIA

<p>Abstract</p> <p>Background</p> <p>The role of estrogens in male physiology has become evident. However, clinically useful normative data for estradiol secretion in boys has not previously been established due to the insensitivity of current methods used in clinical routine. By use of a validated ultra-sensitive extraction RIA, our aim was to establish normative data from a group consisting of healthy boys in prepuberty and during pubertal development.</p> <p>Methods</p> <p>Sixty-two 24-hours serum profiles (6 samples/24 hours) were obtained from 44 healthy boys (ages; 7.2–18.6 years) during their pubertal development, classified into five stages: prepuberty (testis, 1–2 mL), early (testis, 3–6 mL), mid (testis, 8–12 mL), late-1 (testis,15–25 mL, not reached final height) and late-2 (testis,15–25 mL, reached final height). Serum estradiol was determined by an ultra- sensitive extraction radioimmunoassay with detection limit 4 pmol/L and functional sensitivity 6 pmol/L.</p> <p>Results</p> <p>Mean estradiol concentrations during 24-hours secretion increased from prepuberty (median: <4 (5–95 percentiles: <4 – 7) pmol/L) to early puberty (6 (<4 – 12 pmol/L) but then remained relatively constant until a marked increase between mid-puberty (8 (4 – 17) pmol/L) and late-1 (21 (12 – 37) pmol/L) puberty, followed by a slower increase until late-2 puberty (32 (20 – 47) pmol/L). The diurnal rhythm of serum estradiol was non-measurable in pre- and early puberty, but discerned in mid-puberty, and become evident in late pubertal stages with peak values at 0600 to 1000 h.</p> <p>Conclusion</p> <p>With the use of an ultra-sensitive extraction RIA, we have provided clinically useful normative data for estradiol secretion in boys.</p

Hsp70 chaperones: Cellular functions and molecular mechanism

Hsp70 proteins are central components of the cellular network of molecular chaperones and folding catalysts. They assist a large variety of protein folding processes in the cell by transient association of their substrate binding domain with short hydrophobic peptide segments within their substrate proteins. The substrate binding and release cycle is driven by the switching of Hsp70 between the low-affinity ATP bound state and the high-affinity ADP bound state. Thus, ATP binding and hydrolysis are essential in vitro and in vivo for the chaperone activity of Hsp70 proteins. This ATPase cycle is controlled by co-chaperones of the family of J-domain proteins, which target Hsp70s to their substrates, and by nucleotide exchange factors, which determine the lifetime of the Hsp70-substrate complex. Additional co-chaperones fine-tune this chaperone cycle. For specific tasks the Hsp70 cycle is coupled to the action of other chaperones, such as Hsp90 and Hsp100

Status of the ARGOS project

ARGOS is the Laser Guide Star and Wavefront sensing facility for the Large Binocular Telescope. With first laser light on sky in 2013, the system is currently undergoing commissioning at the telescope. We present the overall status and design, as well as first results on sky. Aiming for a wide field ground layer correction, ARGOS is designed as a multi- Rayleigh beacon adaptive optics system. A total of six powerful pulsed lasers are creating the laser guide stars in constellations above each of the LBTs primary mirrors. With a range gated detection in the wavefront sensors, and the adaptive correction by the deformable secondary's, we expect ARGOS to enhance the image quality over a large range of seeing conditions. With the two wide field imaging and spectroscopic instruments LUCI1 and LUCI2 as receivers, a wide range of scientific programs will benefit from ARGOS. With an increased resolution, higher encircled energy, both imaging and MOS spectroscopy will be boosted in signal to noise by a large amount. Apart from the wide field correction ARGOS delivers in its ground layer mode, we already foresee the implementation of a hybrid Sodium with Rayleigh beacon combination for a diffraction limited AO performance

The laser guide star program for the LBT

Laser guide star adaptive optics and interferometry are currently revolutionizing ground-based near-IR astronomy, as demonstrated at various large telescopes. The Large Binocular Telescope from the beginning included adaptive optics in the telescope design. With the deformable secondary mirrors and a suite of instruments taking advantage of the AO capabilities, the LBT will play an important role in addressing major scientific questions. Extending from a natural guide star based system, towards a laser guide stars will multiply the number of targets that can be observed. In this paper we present the laser guide star and wavefront sensor program as currently being planned for the LBT. This program will provide a multi Rayleigh guide star constellation for wide field ground layer correction taking advantage of the multi object spectrograph and imager LUCIFER in a first step. The already foreseen upgrade path will deliver an on axis diffraction limited mode with LGS AO based on tomography or additional sodium guide stars to even further enhance the scientific use of the LBT including the interferometric capabilities.12 page(s