The City of Glasgow Bank failure and the case for liability reform

The City of Glasgow Bank failure in 1878, which led to large numbers of shareholders becoming insolvent, generated great public concern about their plight, and led directly to the 1879 Companies Act, which paved the way for the adoption of limited liability for all shareholders. In this paper, we focus on the question of why the opportunity was not taken to distinguish between the appropriate liability for ‘insiders,’ i.e. those with direct access to information and power over decisions, as contrasted with ‘outsiders.’ We record that such issues were raised and discussed at the time, and we report why proposals for any such graded liability were turned down. We argue that the reasons for rejecting graded liability for insiders were overstated, both then and subsequently. While we believe that the case for such graded liability needs reconsideration, it does remain a complex matter, as discussed in Section 4

Infrared and sub-mm observations of outbursting young stars with Herschel and Spitzer

Episodic accretion plays an important role in the evolution of young stars. Although it has been under investigation for a long time, the origin of such episodic accretion events is not yet understood. We investigate the dust and gas emission of a sample of young outbursting sources in the infrared to get a better understanding of their properties and circumstellar material, and we use the results in a further work to model the objects. We used Herschel data, from our PI program of 12 objects and complemented with archival observations to obtain the spectral energy distributions (SEDs) and spectra of our targets. We report here the main characteristics of our sample, focussing on the SED properties and on the gas emission lines detected in the PACS and SPIRE spectra. The SEDs of our sample show the diversity of the outbursting sources, with several targets showing strong emission in the far-infrared from the embedded objects. Most of our targets reside in a complex environment, which we discuss in detail. We detected several atomic and molecular lines, in particular rotational CO emission from several transitions from J=38-37 to J=4-3. We constructed rotational diagrams for the CO lines, and derived in three domains of assumed local thermodynamic equilibrium (LTE) temperatures and column densities, ranging mainly between 0-100 K and 400-500K. We confirm correlation in our sample between intense CO $J=16-15$ emission and the column density of the warm domain of CO, N(warm). We notice a strong increase in luminosity of HH 381 IRS and a weaker increase for PP 13 S, which shows the beginning of an outburst.Comment: 23 pages, 17 figures, A&A accepte

Science with an ngVLA: Resolving the Radio Complexity of EXor and FUor-type Systems with the ngVLA

Episodic accretion may be a common occurrence in the evolution of young pre-main sequence stars and has important implications for our understanding of star and planet formation. Many fundamental aspects of what drives the accretion physics, however, are still unknown. The ngVLA will be a key tool in understanding the nature of these events. The high spatial resolution, broad spectral coverage, and unprecedented sensitivity will allow for the detailed analysis of outburst systems. The proposed frequency range of the ngVLA allows for observations of the gas, dust, and non-thermal emission from the star and disk.Comment: 8 pages, 1 figure, To be published in the ASP Monograph Series, "Science with a Next-Generation VLA", ed. E. J. Murphy (ASP, San Francisco, CA

Stellar models and isochrones from low-mass to massive stars including pre-main sequence phase with accretion

Grids of stellar models are useful tools to derive the properties of stellar clusters, in particular young clusters hosting massive stars, and to provide information on the star formation process in various mass ranges. Because of their short evolutionary timescale, massive stars end their life while their low-mass siblings are still on the pre-main sequence (pre-MS) phase. Thus the study of young clusters requires consistent consideration of all the phases of stellar evolution. But despite the large number of grids that are available in the literature, a grid accounting for the evolution from the pre-MS accretion phase to the post-MS phase in the whole stellar mass range is still lacking. We build a grid of stellar models at solar metallicity with masses from 0.8 $M_\odot$ to 120 $M_\odot$, including pre-MS phase with accretion. We use the {\sc genec} code to run stellar models on this mass range. The accretion law is chosen to match the observations of pre-MS objects on the Hertzsprung-Russell diagram. We describe the evolutionary tracks and isochrones of our models. The grid is connected to previous MS and post-MS grids computed with the same numerical method and physical assumptions, which provides the widest grid in mass and age to date. Numerical tables of our models and corresponding isochrones are available online

Beyond DNA repair: the novel immunological potential of PARP inhibitors.

Loss of excision repair cross-complementation group 1 (ERCC1), frequently found in lung cancer, and mutations in breast cancer type 1/2 susceptibility genes (BRCA1/2), often found in ovarian, breast and prostate cancers, confer sensitivity to poly-(ADP-ribose) polymerase inhibitors (PARPi). Our work, and that of others, shows that PARPi selectively trigger tumor cell-autonomous immune phenotypes in ERCC1- or BRCA-defective contexts. This suggests that PARPi, used in appropriately selected populations, might mediate their therapeutic effects by potentiating anti-tumor immunity

Alcohol Avoidance Training as a Mobile App for Problem Drinkers:Longitudinal Feasibility Study

Background: Alcohol use is associated with an automatic tendency to approach alcohol, and the retraining of this tendency (cognitive bias modification [CBM]) shows therapeutic promise in clinical settings. To improve access to training and to enhance participant engagement, a mobile version of alcohol avoidance training was developed. Objective: The aims of this pilot study were to assess (1) adherence to a mobile health (mHealth) app; (2) changes in weekly alcohol use from before to after training; and (3) user experience with regard to the mHealth app. Methods: A self-selected nonclinical sample of 1082 participants, who were experiencing problems associated with alcohol, signed up to use the alcohol avoidance training app Breindebaas for 3 weeks with at least two training sessions per week. In each training session, 100 pictures (50 of alcoholic beverages and 50 of nonalcoholic beverages) were presented consecutively in a random order at the center of a touchscreen. Alcoholic beverages were swiped upward (away from the body), whereas nonalcoholic beverages were swiped downward (toward the body). During approach responses, the picture size increased to mimic an approach movement, and conversely, during avoidance responses, the picture size decreased to mimic avoidance. At baseline, we assessed sociodemographic characteristics, alcohol consumption, alcohol-related problems, use of other substances, self-efficacy, and craving. After 3 weeks, 37.89% (410/1082) of the participants (posttest responders) completed an online questionnaire evaluating adherence, alcohol consumption, and user satisfaction. Three months later, 19.03% (206/1082) of the participants (follow-up responders) filled in a follow-up questionnaire examining adherence and alcohol consumption. Results: The 410 posttest responders were older, were more commonly female, and had a higher education as compared with posttest dropouts. Among those who completed the study, 79.0% (324/410) were considered adherent as they completed four or more sessions, whereas 58.0% (238/410) performed the advised six or more training sessions. The study identified a significant reduction in alcohol consumption of 7.8 units per week after 3 weeks (95% CI 6.2-9.4, P&lt;.001; n=410) and another reduction of 6.2 units at 3 months for follow-up responders (95% CI 3.7-8.7, P&lt;.001; n=206). Posttest responders provided positive feedback regarding the fast-working, simple, and user-friendly design of the app. Almost half of the posttest responders reported gaining more control over their alcohol use. The repetitious and nonpersonalized nature of the intervention was suggested as a point for improvement. Conclusions: This is one of the first studies to employ alcohol avoidance training in a mobile app for problem drinkers. Preliminary findings suggest that a mobile CBM app fulfils a need for problem drinkers and may contribute to a reduction in alcohol use. Replicating these findings in a controlled study is warranted.</p

Evidence of pseudoprogression in patients treated with PD1/ PDL1 antibodies across tumor types

Background: PD(L)1 antibodies (anti-PD(L)-1) have been a major breakthrough in several types of cancer. Novel patterns of response and progression have been described with anti-PD(L)-1. We aimed at characterizing pseudoprogression (PSPD) among patients with various solid tumor types treated by anti-PD(L)-1. Methods: All consecutive patients (pts) enrolled in phase 1 trials with advanced solid tumors and lymphomas treated in phase I clinical trials evaluating monotherapy by anti-PD(L)-1 at Gustave Roussy were analyzed. We aimed to assess prevalence and outcome of PSPD across tumor types. We also intended to describe potential clinical and pathological factors associated with PSPD. Results: A total of 169 patients treated with anti-PD(L)-1 were included in the study. Most frequent tumor types included melanoma (n = 57) and non-small cell lung cancer (n = 19). At first tumor evaluation 77 patients (46%) presented with immune unconfirmed progressive disease. Six patients (8%) experienced PSPD: 2 patients with partial response; 4 patients with stable disease. Increase in target lesions in the first CT-scan was more frequently associated to PSPD (67% vs 33%; P = .04). Patients with a PSPD had a superior survival when compared to patients progressing (median OS: 10.7 months vs 8.7 months; P = .07). Conclusions: A small subset of PSPD patients may experience response after an initial progression. Assessment of the current strategy for immune-related response evaluations may require further attention