Carcinoma of the cervix complicating a genital prolapse.

Although uterine prolapse and carcinoma of the uterine cervix are not rare events, their association is very uncommon. The treatment of cervical cancer has been protocolled, but the management of uterovaginal prolapse associated with carcinoma of the cervix is not standardised and therapy strategies vary considerably among authors. Our case reports a 74-year-old patient, admitted to the emergency department with an ulcerated prolapsed uterus. Biopsy of the cervical lesion confirmed a squamous-cell carcinoma. The patient underwent vaginal hysterectomy plus open bilateral iliopelvic lymphadenectomy complemented with radiotherapy with quimiosensibilisation. With this aggressive treatment approach, there was progression of the disease. The authors believe that this case typiaddition to the few published reports

Proposal to study Bs→DˉsJB_s \to \bar D_{sJ} transitions

It is proposed to clear some of the puzzles of B decay to the broad $\bar{D}^{\ast\ast}$ states by studying the corresponding decay with strange states $B_s^0 \to D_{s0}^{\ast -} \pi^+$ at LHCb. Interpretation of the results should be easier due to the narrowness of the $D_{s0}^{\ast -}$ state.Comment: 21 page

Distinguishing the albedo of exoplanets from stellar activity

Light curves show the flux variation from the target star and its orbiting planets as a function of time. In addition to the transit features created by the planets, the flux also includes the reflected light component of each planet, which depends on the planetary albedo. This signal is typically referred to as phase curve and could be easily identified if there were no additional noise. As well as instrumental noise, stellar activity, such as spots, can create a modulation in the data, which may be very difficult to distinguish from the planetary signal. We analyze the limitations imposed by the stellar activity on the detection of the planetary albedo, considering the limitations imposed by the predicted level of instrumental noise and the short duration of the observations planned in the context of the CHEOPS mission. As initial condition, we have assumed that each star is characterized by just one orbiting planet. We built mock light curves that included a realistic stellar activity pattern, the reflected light component of the planet and an instrumental noise level, which we have chosen to be at the same level as predicted for CHEOPS. We then fit these light curves to try to recover the reflected light component, assuming the activity patterns can be modeled with a Gaussian process.We estimate that at least one full stellar rotation is necessary to obtain a reliable detection of the planetary albedo. This result is independent of the level of noise, but it depends on the limitation of the Gaussian process to describe the stellar activity when the light curve time-span is shorter than the stellar rotation. Finally, in presence of typical CHEOPS gaps in the simulations, we confirm that it is still possible to obtain a reliable albedo.Comment: Accepted for publication in A&A, 14 pages, 12 figure

Design during COVID-19: Agents and allies in the role of designer, digital fabrication and distributed production

During COVID-19 global emergency, designers proposed solutions at different scales, as quick responses to demands from different agents. In the same way, we critically analyzed the emergence of allies, protocols and tools, which allowed the optimization of fabrication, from traditional manufacturing into distributed co-production. The analyzed local networks produced global co-design experiences, with involvement of FabLabs and users from different disciplines. Through case studies and the evaluation of surveys and testimonials from users and makers, we analyze the global panorama, to finally explore the specific situation in Latin America. This establishes a relationship between medical demand and digital fabrication, which allows evidence of positive and negative situations to be consider as new, significant aspects for the design in the future. The leading role acquired by the ecosystem surrounding digital fabrication during the pandemic, could enhance its processes in the search for greater positioning, changing society from within the different communities

Resource-on-demand schemes in 802.11 WLANs with non-zero start-up times

Increasing the density of access points is one of the most effective mechanisms to cope with the growing traffic demand in wireless networks. To prevent energy wastage at low loads, a resource-on-demand (RoD) scheme is required to opportunistically (de)activate access points as network traffic varies. While previous publications have analytically modeled these schemes in the past, they have assumed that resources are immediately available when activated, an assumption that leads to inaccurate results and might result in inappropriate configurations of the RoD scheme. In this paper, we analyze a general RoD scenario with N access points and non-zero start-up times. We first present an exact analytical model that accurately predicts performance but has a high computational complexity, and then derive a simplified analysis that sacrifices some accuracy in exchange for a much lower computational cost. To illustrate the practicality of this model, we present the design of a simple configuration algorithm for RoD. Simulation results confirm the validity of the analyses, and the effectiveness of the configuration algorithm

Replicase mediated resistance against Potato Leafroll Virus in potato Desirée plants.

Potato leafroll virus (PLRV) is a major menace for the potato production all over the world. PLRV is transmitted by aphids, and until now, the only strategy available to control this pest has been to use large amounts of insecticides. Transgenic approaches involving the expression of viral replicases are being developed to provide protection for plants against viral diseases. The purpose of this study was to compare the protection afforded by the differential expression of PLRV replicase transgene in potato plants cv. Desirée. Plants were genetically modified to express the complete sense PLRV replicase gene. Two constructions were used, one containing the constitutive 35SCaMV promoter and the other the phloem-specific RolA promoter from Agrobacterium rhizogenes. Transgenic plants were infected with PLRV in vitro, using infested aphids. In plants in which 35SCaMV controlled the expression of the PLRV replicase gene, signs of infection were initially detected, although most plants later developed a recovery phenotype showing undetectable virus levels 40 days after infection. In turn, those plants with the RolA promoter displayed an initial resistance that was later overcome. Different molecular mechanisms are likely to participate in the response to PLRV infection of these two types of transgenic plants