Global Insanity Redux

In our book Global Insanity we argued that the existential predicament faced by humanity is a predictable consequence of Western Enlightenment thinking and the resulting world model, whose ascendance with the Industrial Revolution entrained development of the global consumer Economy that is destroying the biosphere. This situation extends from a dominant mindset based on the philosophy of reductionism.  The problem was recognized and characterized by Robert M. Hutchins.  In 1985, Hutchins ideas were discussed by Robert Rosen in Chapter 1 of Anticipatory Systems: Philosophical, Mathematical & Methodological Foundations.  Building on Hutchins' ideas, Rosen laid the foundation for an entire new, non-reductionist paradigm, which he called "complexity theory".  This new paradigm is what we are further developing here.  One has to recognize that a paradigm shift is needed to overcome the entrenched mindset and world model that reductionism has created. Here we explore the myriad interconnected ways-psychological, social, cultural, political, and technological-that the Western world model and consumer economy works as a complex system to thwart, neutralize, or co-opt for its own ends any effort to bring about the kind of radical change that is needed to avert global ecological catastrophe and societal collapse. This resistance to change stems from the need, inherent in the Western model, to continually grow the consumer economy.  The media's continued portrayal of consumptive economic growth as a good thing, the widely held belief that the Economy is paramount, and current political and technological trends all manifest the system's active resistance to change. From the perspective of the mature economic system, any work that does not serve to grow the Economy is counterproductive, and viewed as unnecessary, a luxury, or subversive. The potential for real change (i.e. toward creation of a better system) is thus inversely related to the viability of the Economy, which will eventually decline as the system develops into senescence. To the extent that the fragile metastability of senescence affords opportunity for radical change, economic decline can be viewed as a hopeful sign. But taking maximum advantage of that opportunity will be extraordinarily difficult, as it will require widespread recognition of the problem, major voluntary sacrifice by the relatively large numbers of people who still benefit from the system (including what remains of the "middle class"), and concerted "grassroots" efforts.  It can be expected that the system will resist those efforts until the end, becoming increasingly reliant on media-enabled distraction and divisive politics, as well as violent coercion, to maintain itself.  Investment in education and science is widely touted as necessary for improving our situation, but this is misguided as long as the educational system and scientific enterprise continue to work in collusion with the larger system, as they currently do. Until the reductionist mindset and world model that drives the system is effectively challenged, there can be little hope for the kind of change needed to avert the catastrophic collapse of civilization

Single-order-parameter description of glass-forming liquids:A one-frequency test

Thermo-viscoelastic linear-response functions are calculated from the master equation describing viscous liquid inherent dynamics. From the imaginary parts of the frequency-dependent isobaric specific heat, isothermal compressibility, and isobaric thermal expansion coefficient, we define a "linear dynamic Prigogine-Defay ratio" with the property that if this quantity is unity atone frequency, then it is unity at all frequencies. This happens if and only if there is a single-order-parameter description of the thermo-viscoelastic linear responses via an order parameter (which may be non-exponential in time). Generalizations to other cases of thermodynamic control parameters than temperature and pressure are treated in an Appendix.Comment: Replaces arXiv:cond-mat/040570

Genomic SELEX for Hfq-binding RNAs identifies genomic aptamers predominantly in antisense transcripts

An unexpectedly high number of regulatory RNAs have been recently discovered that fine-tune the function of genes at all levels of expression. We employed Genomic SELEX, a method to identify protein-binding RNAs encoded in the genome, to search for further regulatory RNAs in Escherichia coli. We used the global regulator protein Hfq as bait, because it can interact with a large number of RNAs, promoting their interaction. The enriched SELEX pool was subjected to deep sequencing, and 8865 sequences were mapped to the E. coli genome. These short sequences represent genomic Hfq-aptamers and are part of potential regulatory elements within RNA molecules. The motif 5′-AAYAAYAA-3′ was enriched in the selected RNAs and confers low-nanomolar affinity to Hfq. The motif was confirmed to bind Hfq by DMS footprinting. The Hfq aptamers are 4-fold more frequent on the antisense strand of protein coding genes than on the sense strand. They were enriched opposite to translation start sites or opposite to intervening sequences between ORFs in operons. These results expand the repertoire of Hfq targets and also suggest that Hfq might regulate the expression of a large number of genes via interaction with cis-antisense RNAs

The Peter Pan paradigm

Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established, however, is the role of delay in the developmental processes that yield functionally immature tissues at birth. Evidence is mounting that organs do not continue to develop postnatally in the context of these organogenesis insults, condemning the patient to utilize under-developed tissues for adult processes. These poorly differentiated organs may appear histologically normal at birth but with age may deteriorate revealing progressive or adult-onset pathology. The genetic and molecular underpinning of the proposed paradigm reveals the need for a comprehensive systems biology approach to evaluate the role of maternal-fetal environment on organogenesis

Transport lattice models of heat transport in skin with spatially heterogeneous, temperature-dependent perfusion

BACKGROUND: Investigation of bioheat transfer problems requires the evaluation of temporal and spatial distributions of temperature. This class of problems has been traditionally addressed using the Pennes bioheat equation. Transport of heat by conduction, and by temperature-dependent, spatially heterogeneous blood perfusion is modeled here using a transport lattice approach. METHODS: We represent heat transport processes by using a lattice that represents the Pennes bioheat equation in perfused tissues, and diffusion in nonperfused regions. The three layer skin model has a nonperfused viable epidermis, and deeper regions of dermis and subcutaneous tissue with perfusion that is constant or temperature-dependent. Two cases are considered: (1) surface contact heating and (2) spatially distributed heating. The model is relevant to the prediction of the transient and steady state temperature rise for different methods of power deposition within the skin. Accumulated thermal damage is estimated by using an Arrhenius type rate equation at locations where viable tissue temperature exceeds 42°C. Prediction of spatial temperature distributions is also illustrated with a two-dimensional model of skin created from a histological image. RESULTS: The transport lattice approach was validated by comparison with an analytical solution for a slab with homogeneous thermal properties and spatially distributed uniform sink held at constant temperatures at the ends. For typical transcutaneous blood gas sensing conditions the estimated damage is small, even with prolonged skin contact to a 45°C surface. Spatial heterogeneity in skin thermal properties leads to a non-uniform temperature distribution during a 10 GHz electromagnetic field exposure. A realistic two-dimensional model of the skin shows that tissue heterogeneity does not lead to a significant local temperature increase when heated by a hot wire tip. CONCLUSIONS: The heat transport system model of the skin was solved by exploiting the mathematical analogy between local thermal models and local electrical (charge transport) models, thereby allowing robust, circuit simulation software to obtain solutions to Kirchhoff's laws for the system model. Transport lattices allow systematic introduction of realistic geometry and spatially heterogeneous heat transport mechanisms. Local representations for both simple, passive functions and more complex local models can be easily and intuitively included into the system model of a tissue

Complexity Theory for a New Managerial Paradigm: A Research Framework

In this work, we supply a theoretical framework of how organizations can embed complexity management and sustainable development into their policies and actions. The proposed framework may lead to a new management paradigm, attempting to link the main concepts of complexity theory, change management, knowledge management, sustainable development, and cybernetics. We highlight how the processes of organizational change have occurred as a result of the move to adapt to the changes in the various global and international business environments and how this transformation has led to the shift toward the present innovation economy. We also point how organizational change needs to deal with sustainability, so that the change may be consistent with present needs, without compromising the future

Brain Complexity: Analysis, Models and Limits of Understanding

Abstract. Manifold initiatives try to utilize the operational principles of organisms and brains to develop alternative, biologically inspired computing paradigms. This paper reviews key features of the standard method applied to complexity in the cognitive and brain sciences, i.e. decompositional analysis. Projects investigating the nature of computations by cortical columns are discussed which exemplify the application of this standard method. New findings are mentioned indicating that the concept of the basic uniformity of the cortex is untenable. The claim is discussed that non-decomposability is not an intrinsic property of complex, integrated systems but is only in our eyes, due to insufficient mathematical techniques. Using Rosen’s modeling relation, the scientific analysis method itself is made a subject of discussion. It is concluded that the fundamental assumption of cognitive science, i.e., cognitive and other complex systems are decomposable, must be abandoned.