The Lay Summary in Medical Research Proposals - is it becoming more important?

One of the skills every researcher must learn is how to present complex ideas and medical or scientific terms to a “lay” audience, for example members of the public, carers, long-term users of services, organisations representing consumers’ interests, members of the public who are the potential receipients of health promotion programmes or those from a different clinical or academic background to their own. This poster will examine: 1. What is a lay summary? A brief summary of a research project or a research proposal ... written for a lay audience , rather than researchers or professionals ... written in plain English ... avoiding the use of jargon ... explaining any technical terms. 2. The three purposes of a lay summary: • Grant and Ethical review, in particular to ensure a project is accessible by laypersons who are becoming more involved in the peer review process in some funders e.g. National Institute for Health Research – Research for Patient Benefit scheme • Public understanding of science, particularly important for fundraising charities • Raising and justifying funds from government for science to underpin improvements in healthcare 3. What should a lay summary contain? The role of the lay summary is changing, and for many funders it is clearly becoming more important, for example the Arthritis Research Campaign are putting projects to a lay audience for assessment before scientific peer review

Resolved Imaging of the HD191089 Debris Disc

Two thirds of the F star members of the 12 Myr old Beta Pictoris Moving Group (BPMG) show significant excess emission in the mid-infrared, several million years after the expected dispersal of the protoplanetary disc. Theoretical models of planet formation suggest that this peak in the mid-infrared emission could be due to the formation of Pluto-sized bodies in the disc, which ignite the collisional cascade and enhance the production of small dust. Here we present resolved mid-infrared imaging of the disc of HD191089 (F5V in the BPMG) and consider its implications for the state of planet formation in this system. HD191089 was observed at 18.3 microns using T-ReCS on Gemini South and the images were compared to models of the disc to constrain the radial distribution of the dust. The emission observed at 18.3 microns is shown to be significantly extended beyond the PSF at a position angle of 80 degrees. This is the first time dust emission has been resolved around HD191089. Modelling indicates that the emission arises from a dust belt from 28-90 AU, inclined at 35 degrees from edge on with very little emission from the inner 28AU of the disc, indicating the presence of an inner cavity. The steep slope of the inner edge is more consistent with truncation by a planet than with ongoing stirring. A tentative brightness asymmetry F(W)/F(E)=0.80+/-0.12 (1.8 sigma) between the two sides of the disc could be evidence for perturbations from a massive body on an eccentric orbit in the system.Comment: 11 Pages Accepted to MNRA

Effect of plyometric training on swimming block start performance in adolescents

This study aimed to identify the effect of plyometric training (PT), when added to habitual training (HT) regimes, on swim start performance. After the completion of a baseline competitive swim start, 22 adolescent swimmers were randomly assigned to either a PT (n = 11, age: 13.1 ± 1.4 yr, mass: 50.6 ± 12.3 kg, stature: 162.9 ± 11.9 cm) or an HT group (n = 11, age: 12.6 ± 1.9 yr, mass: 43.3 ± 11.6 kg, stature: 157.6 ± 11.9 cm). Over an 8-week preseason period, the HT group continued with their normal training program, whereas the PT group added 2 additional 1-hour plyometric-specific sessions, incorporating prescribed exercises relating to the swimming block start (SBS). After completion of the training intervention, post-training swim start performance was reassessed. For both baseline and post-trials, swim performance was recorded using videography (50Hz Canon MVX460) in the sagital plane of motion. Through the use of Silicon Coach Pro analysis package, data revealed significantly greater change between baseline and post-trials for PT when compared with the HT group for swim performance time to 5.5 m (−0.59 s vs. −0.21 s; p < 0.01) and velocity of take-off to contact (0.19 ms−1 vs. −0.07 ms−1; p < 0.01). Considering the practical importance of a successful swim start to overall performance outcome, the current study has found that inclusion of suitable and safely implemented PT to adolescent performers, in addition to HT routines, can have a positive impact on swim start performance

Quantifying the timescales of fluid-rock interaction on Mars using the nakhlite meteorites

Etch pits within olivine grains from the nakhlite meteorites reveal the magnitude and timescale of water-mediated alteration of the martian crust

Exploring Environmental-Economic Benefits from Agri-Industrial Diversification in the Sugar Industry: An Integrated Land Use and Value Chain Approach

The sugar industry in Queensland (Australia) is confronted with increasing economic pressure and environmental constraints. To explore whether agri-industrial diversification of the sugar industry provides a sustainable development pathway for the region, we develop a spatial environmental-economic approach that integrates a land use and value chain model with a hydrological model. Results indicate that agri-industrial diversification can lead to substantial increases in regional income, while at the same time increasing the resilience of a sugar industry facing decreasing sugar prices. Agri-industrial diversification drives land use diversification, which under current sugar prices does not lead to a reduction in sugarcane production. Water quality benefits from this land use diversification are mixed, and depend on the economic viability and erosion characteristics of the concerned production systems.spatial economics, environmental economics, value chains, agri-industries, water quality, Environmental Economics and Policy, Land Economics/Use, C6, O18, Q13, Q53,

The Effect of Budgets on Doctor Behaviour: Evidence From A Natural Experiment

In many health care systems primary care physicians act as 'gatekeepers' to secondary care. We investigates the impact of the UK fundholding scheme under which general practices could elect to hold a budget to meet the costs of elective surgery for their patients. We use a differences in differences methodology on a large four year panel of English general practices before and after the abolition of fundholding. Fundholding incentives reduced fundholder elective admission rates by 3.3% and accounted for 57% of the difference between fundholder and nonfundholder elective admissions, with 43% a selection effect due to unobservable differences in practice characteristics. Fundholding had no effect on emergency admissions.Budgets; Health care; Fundholding; Admission rates

Using molecular mechanics to predict bulk material properties of fibronectin fibers

The structural proteins of the extracellular matrix (ECM) form fibers with finely tuned mechanical properties matched to the time scales of cell traction forces. Several proteins such as fibronectin (Fn) and fibrin undergo molecular conformational changes that extend the proteins and are believed to be a major contributor to the extensibility of bulk fibers. The dynamics of these conformational changes have been thoroughly explored since the advent of single molecule force spectroscopy and molecular dynamics simulations but remarkably, these data have not been rigorously applied to the understanding of the time dependent mechanics of bulk ECM fibers. Using measurements of protein density within fibers, we have examined the influence of dynamic molecular conformational changes and the intermolecular arrangement of Fn within fibers on the bulk mechanical properties of Fn fibers. Fibers were simulated as molecular strands with architectures that promote either equal or disparate molecular loading under conditions of constant extension rate. Measurements of protein concentration within micron scale fibers using deep ultraviolet transmission microscopy allowed the simulations to be scaled appropriately for comparison to in vitro measurements of fiber mechanics as well as providing estimates of fiber porosity and water content, suggesting Fn fibers are approximately 75% solute. Comparing the properties predicted by single molecule measurements to in vitro measurements of Fn fibers showed that domain unfolding is sufficient to predict the high extensibility and nonlinear stiffness of Fn fibers with surprising accuracy, with disparately loaded fibers providing the best fit to experiment. This work shows the promise of this microstructural modeling approach for understanding Fn fiber properties, which is generally applicable to other ECM fibers, and could be further expanded to tissue scale by incorporating these simulated fibers into three dimensional network models

Does Better Disease Management in Primary Care Reduce Hospital Costs?

We apply cross-sectional and panel data methods to a database of 5 million patients in 8,000 English general practices to examine whether better primary care management of 10 chronic diseases is associated with reduced hospital costs. We find that only primary care performance in stroke care is associated with lower hospital costs. Our results suggest that the 10% improvement in the general practice quality of stroke care between 2004/5 and 2007/8 reduced 2007/8 hospital expenditure by about £130 million in England. The cost savings are due mainly to reductions in emergency admissions and outpatient visits, rather than to lower costs for patients treated in hospital or to reductions in elective admissions.Quality; disease management; primary care; hospital costs; ambulatory care sensitive conditions; preventative care.

Advancing imaging technologies for patients with spinal pain : with a focus on whiplash injury

Background: Radiological observations of soft-tissue changes that may relate to clinical symptoms in patients with traumatic and non-traumatic spinal disorders are highly controversial. Studies are often of poor quality and findings are inconsistent. A plethora of evidence suggests some pathoanatomical findings from traditional imaging applications are common in asymptomatic participants across the life span, which further questions the diagnostic, prognostic, and theranostic value of traditional imaging. Although we do not dispute the limited evidence for the clinical importance of most imaging findings, we contend that the disparate findings across studies may in part be due to limitations in the approaches used in assessment and analysis of imaging findings. Purpose: This clinical commentary aimed to (1) briefly detail available imaging guidelines, (2) detail research-based evidence around the clinical use of findings from advanced, but available, imaging applications (eg, fat and water magnetic resonance imaging and magnetization transfer imaging), and (3) introduce how evolving imaging technologies may improve our mechanistic understanding of pain and disability, leading to improved treatments and outcomes. Study Design/Setting: A non-systematic review of the literature is carried out. Methods: A narrative summary (including studies from the authors' own work in whiplash injuries) of the available literature is provided. Results: An emerging body of evidence suggests that the combination of existing imaging sequences or the use of developing imaging technologies in tandem with a good clinical assessment of modifiable risk factors may provide important diagnostic information toward the exploration and development of more informed and effective treatment options for some patients with traumatic neck pain. Conclusions: Advancing imaging technologies may help to explain the seemingly disconnected spectrum of biopsychosocial signs and symptoms of traumatic neck pain

Developing Virus-like Particles as High-density Photoreporting Platforms using Noncanonical Amino Acids and Click Chemistry

Light-based imaging and microscopy techniques are compelling diagnostic tools that provide straightforward data. Furthermore, single-particle targeting and tracking has the potential to provide new insight on myriad phenomenon, such as small particle diffusion, particle-membrane interaction, single-particle microfluidics, and many aspects of microbiology and physiology. However, limitations exist in current technologies’ ability to achieve tracking of individual nanoparticles due to inability to sufficiently label or stain single targets with traditional probes. This work proposes a method to overcome probe density by creating individual probes based on virus-based nanoparticles densely decorated with many reporter probes. We present the steps to produce such reporters. This technology has the potential to provide insight into single particle pathways that might otherwise only be measured with bulk properties such as single-particle dynamics in microgravity