Studii privind caracterele morfobiologice, productivitatea şi rezistenţa la temperaturi înalte la tomate

The paper presents the results of the appreciation of varieties and lines from the collection of tomatoes of the Institute of Genetics, Plant Physiology and Plant Protection, Republic of Moldova based on productivity, resistance to stressing temperatures and some fruit characters. The analysis of the useful characters of the studied forms from the collection revealed a wide variability in the fruit characters, the overall productivity, the share of the fruits, which allows selection and recommendation of the most valuable forms for hybridization and obtaining new varieties and hybrids of different destination. Cluster analysis (k-means method) demonstrated that the 38°C temperature level manifested a higher discriminative capacity of tomato clusters based on root and strain length (controlled conditions), which revealed the more pronounced interaction specificity with this temperature level. Were identified clusters of tomato genotypes with diminished reaction at stressful temperatures, which is important for the involvement in programs to improve genotypes with increased resistance to heat

THE GASTROINTESTINAL NEUROENDOCRIN TUMORS

Objectives. The gastrointestinal neuroendocrin tumors are rare events with clinical presentation widely variable and surgical management that is often challenging. Material and methods. We performed a retrospective study in the First Surgical Clinic, St Spiridon University Hospital, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania, in the 2005-2019 period, which included all the patients diagnosed with gastrointestinal neuroendocrin tumors by immunehistochemistry. Results. There were 37 cases diagnosed with gastrointestinal neuroendocrin tumors. The ratio male/female was 15/22 and mean age was de 42±4.365 years old (range 27-79 years). The gastrointestinal neuroendocrin tumors were: 13 – gastric, one – duodenal, 10 cases – small intestine, 10 cases – appendicular, 7 cases – large intestine and hepatic metastases – 4 cases. The carcinoid syndrome was present in 7 cases. The biological diagnosis included biological markers (e.g. serotonine, 5-HIAA). Diagnosis of the tumor site and dimension was done by ultrasound exam, Computed Tomography scan, Positron Emission Tomography scan, Octreoscan and intraoperative ultrasonography. Surgical procedures for gastric neuroendocrin tumors were: wedge tumor resection – one case; subtotal gastrectomy – one case, total gastrectomies – 3 cases. For neuroendocrin tumors of small bowel we performed 6 enterectomies and 4 ileocolectomies with lymphadenectomy. We also performed 7 appendectomies and 3 right colectomies for appendicular carcinoids. We performed 4 right colectomies, 2 left colectomies and one low anterior resection of the rectum for colorectal neuroendocrin tumors. For neuroendocrin tumors with hepatic metastases disease we performed one hepatectomy and 3 termoablations. Conclusions. The gastrointestinal neuroendocrin tumors are rare tumors, and their management is always challenging. Immunohistochemistry is mandatory for confirmation, appreciation of the proliferation and biological behavior, and permissible to use specific therapy. Aggressive surgical treatment is indicated, even in advanced stages. The treatment in patients with advanced gastrointestinal neuroendocrin tumors with metastatic disease include chemotherapy, biological therapies, and peptide receptor radionuclide therapy

THE GASTROINTESTINAL NEUROENDOCRIN TUMORS

Objectives. The gastrointestinal neuroendocrin tumors are rare events with clinical presentation widely variable and surgical management that is often challenging. Material and methods. We performed a retrospective study in the First Surgical Clinic, St Spiridon University Hospital, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania, in the 2005-2019 period, which included all the patients diagnosed with gastrointestinal neuroendocrin tumors by immunehistochemistry. Results. There were 37 cases diagnosed with gastrointestinal neuroendocrin tumors. The ratio male/female was 15/22 and mean age was de 42±4.365 years old (range 27-79 years). The gastrointestinal neuroendocrin tumors were: 13 – gastric, one – duodenal, 10 cases – small intestine, 10 cases – appendicular, 7 cases – large intestine and hepatic metastases – 4 cases. The carcinoid syndrome was present in 7 cases. The biological diagnosis included biological markers (e.g. serotonine, 5-HIAA). Diagnosis of the tumor site and dimension was done by ultrasound exam, Computed Tomography scan, Positron Emission Tomography scan, Octreoscan and intraoperative ultrasonography. Surgical procedures for gastric neuroendocrin tumors were: wedge tumor resection – one case; subtotal gastrectomy – one case, total gastrectomies – 3 cases. For neuroendocrin tumors of small bowel we performed 6 enterectomies and 4 ileocolectomies with lymphadenectomy. We also performed 7 appendectomies and 3 right colectomies for appendicular carcinoids. We performed 4 right colectomies, 2 left colectomies and one low anterior resection of the rectum for colorectal neuroendocrin tumors. For neuroendocrin tumors with hepatic metastases disease we performed one hepatectomy and 3 termoablations. Conclusions. The gastrointestinal neuroendocrin tumors are rare tumors, and their management is always challenging. Immunohistochemistry is mandatory for confirmation, appreciation of the proliferation and biological behavior, and permissible to use specific therapy. Aggressive surgical treatment is indicated, even in advanced stages. The treatment in patients with advanced gastrointestinal neuroendocrin tumors with metastatic disease include chemotherapy, biological therapies, and peptide receptor radionuclide therapy

18 years of Romanian national program of liver transplant - a retrospective analysis of 924 patients operated

Center of General Surgery and Liver Transplantation “Dan Setlacec”, Fundeni Clinical Institute, Bucharest, Romania, Al XIII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” și al III-lea Congres al Societății de Endoscopie, Chirurgie miniminvazivă și Ultrasonografie ”V.M.Guțu” din Republica MoldovaIntroducere: Transplantul hepatic (TH) a devenit un tratament stabil pentru boala hepatică în stadiu final, cu peste 20.000 de proceduri la nivel mondial anual. Prelegerea prezintă și analizează înființarea și rezultatele Programului Național Român al TH. Material și metode: Între aprilie 2000 și decembrie 2018, 924 pacienti au efectuat 964 operatii de TH în România. Raportul dintre bărbați și femei a fost de 546/378, în timp ce raportul adult / pediatric a fost de 857/67, cu o vârstă medie de 46 de ani (mediană de 50 de ani, interval de 7 luni - 68 de ani). Principalele indicații TH au fost ciroza VHB (270 pac., 29%), CHC (196 pac., 21%) și ciroza VHC (141 pac., 15%). Rezultate: TH de la donator aflat in moarte cerebrala a fost efectuat în 805 de cazuri: TH total în 778 de cazuri, TH împărțit (split) în 20 de cazuri, LT redus în 5 cazuri, LT accesoriu în 1 caz și domino LT în 1 pac. TH de la donator inrudit a fost efectuat în 159 de pacienti:cu hemificat drept la113 pac (12%), secțiune laterală stânga la 30 pac (3%), cu hemificat stang la 14 pac (1,5%) și LDLT dual graft la 2 pacienti. Rata generală de morbiditate majoră a fost de 42% (cel puțin clasa IIIB Clavien-Dindo), în timp ce mortalitatea perioperatorie a fost de 8%. Rata de retransplantare a fost de 4,3% (40 de pac). Pe termen lung, ratele de supraviețuire estimate la pacienți cu 1, 3 și 5 ani au fost de 88%, 82% și, respectiv, 79%. Concluzii: Programul național de transplant hepatic abordează toate cauzele insuficienței hepatice acute și cronice sau a tumorilor hepatice la adulți și copii, folosind toate tehnicile chirurgicale, cu rezultate bune pe termen lung. Programul a evoluat constant în timp, ceea ce a dus la scăderea ratei mortalității pe lista de așteptare. * * * Introduction: Liver transplantation (LT) has become an established treatment for end-stage liver disease, with more than 20.000 procedures yearly worldwide. The lecture presents and analyzes the setting-up and results of the Romanian National Program of LT. Material and methods: Between April 2000 and December 2018, 924 pts received 964 LTs in Romania. Male/female ratio was 546/378, while adult/pediatric ratio was 857/67, with a mean age of 46 years (median 50 yrs; range 7 months – 68 yrs). Main LT indications were HBV cirrhosis (270 pts; 29%), CHC (196 pts; 21%), and HCV cirrhosis (141 pts; 15%). Results: Deceased donor LT was performed in 805 cases: whole LT in 778 cases, split LT in 20 cases, reduced LT in 5 cases, accesory LT in 1 case, and domino LT in 1 pt. Living donor LT was performed in 159 pts: right hemiliver in 113 pts (12%), left lateral section in 30 pts (3%), left hemiliver in 14 pts (1.5%), and dual graft LDLT in 2 pts. Overall major morbidity rate was 42% (at least IIIB Clavien-Dindo class), while perioperative mortality was 8%. Retransplantation rate was 4.3% (40 pts). Long-term overall 1, 3, and 5-year estimated survival rates for patients were 88%, 82%, and 79%, respectively. Conclusions: The Romanian National program for liver transplantation addresses all causes of acute and chronic liver failure or liver tumors in adults and children, using all surgical techniques, with good long-term outcome. The program constantly evolved over time, leading to decreased mortality rate on the waiting list