531 research outputs found

    Stochastic reconstruction of sandstones

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    A simulated annealing algorithm is employed to generate a stochastic model for a Berea and a Fontainebleau sandstone with prescribed two-point probability function, lineal path function, and ``pore size'' distribution function, respectively. We find that the temperature decrease of the annealing has to be rather quick to yield isotropic and percolating configurations. A comparison of simple morphological quantities indicates good agreement between the reconstructions and the original sandstones. Also, the mean survival time of a random walker in the pore space is reproduced with good accuracy. However, a more detailed investigation by means of local porosity theory shows that there may be significant differences of the geometrical connectivity between the reconstructed and the experimental samples.Comment: 12 pages, 5 figure

    IL11 (Interleukin-11) causes emphysematous lung disease in a mouse model of marfan syndrome.

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    BACKGROUND: Marfan Syndrome (MFS) is an inherited connective tissue disorder caused by mutations in the FBN1 (fibrillin-1) gene. Lung abnormalities are common in MFS, but their pathogenesis is poorly understood. IL11 (interleukin-11) causes aortic disease in a mouse model of MFS and was studied here in the lung. METHODS: We examined histological and molecular phenotypes in the lungs of Fbn1C1041G/+ mice (mouse model of Marfan Syndrome [mMFS]), an established mouse model of MFS. To identify IL11-expressing cells, we used immunohistochemistry on lungs of 4- and 16-week-old Fbn1C1041G/+:Il11EGFP/+ reporter mice. We studied the effects of IL11 inhibition by RT-qPCR, immunoblots and histopathology in lungs from genetic or pharmacologic models: (1) 16-week-old IL11 receptor (IL11RA) knockout mMFS mice (Fbn1C1041G/+:Il11ra1-/- mice) and (2) in mMFS mice administered IgG control or interleukin-11 receptor antibodies twice weekly from 4 to 24 weeks of age. RESULTS: mMFS lungs showed progressive loss and enlargement of distal airspaces associated with increased proinflammatory and profibrotic gene expression as well as matrix metalloproteinases 2, 9, and 12. IL11 was increased in mMFS lungs and localized to smooth muscle and endothelial cells in young mMFS mice in the Fbn1C1041G/+:Il11EGFP/+ reporter strain and in fibroblasts, in older mice. In mMFS mice, genetic (Fbn1C1041G/+:Il11ra1-/-) or pharmacologic (anti-interleukin-11 receptor) inhibition of IL11 signaling reduced lung emphysema, fibrosis, and inflammation. This protective effect was associated with reduced pathogenic ERK1/2 signaling and lower metalloproteinase 2, 9, and 12 expression. CONCLUSIONS: IL11 causes lung disease in mMFS. This reveals a shared IL11-driven disease mechanism in lung and aorta in MFS and suggests inhibition of IL11 signaling as a holistic approach for treating multiorgan morbidity in MFS

    Enhanced localization with adaptive normal distribution transform Monte Carlo localization for map based navigation robot

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    Map-based navigation is the common navigation method used among the mobile robotic application. The localization plays an important role in the navigation where it estimates the robot position in an environment. Monte Carlo Localization (MCL) is found as the widely used estimation algorithm due to it non-linear characteristic. There are classifications of MCL such as Adaptive MCL (AMCL), Normal Distribution Transform MCL (NDT-MCL) which can perform better than the MCL. However, AMCL is adaptive to particles but the position estimation accuracy is not optimized. NDT-MCL has good position estimation but it requires higher number of particles which results in higher computational effort. The objective of the research is to design and develop a localization algorithm which can achieve better performance in term of position estimation and computational effort. The new MCL algorithm which is named as Adaptive Normal Distribution Transform Monte Carlo Localization (ANDT-MCL) is then designed and developed. It integrates Kullback–Leibler divergence, Normal Distribution Transform and Systematic Resampling into the algorithm. Three experiments are conducted to evaluate the performance of proposed ANDT-MCL in simulated environment. These experiments include evaluating the performance of ANDT-MCL with different path shape, distance and velocity. In the end of the research work, the proposed ANDT-MCL is successfully developed. It is adaptive to the number of particles used, higher position estimation and lower computational effort than existing algorithms. The algorithm can produce better position estimation with less computational effort in any kind paths and is consistent in long journey as well as can outperform in high speed navigation

    EXACT RUN LENGTH DISTRIBUTION OF THE DOUBLE SAMPLING X CHART WITH ESTIMATED PROCESS PARAMETERS

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    Since the run length distribution is generally highly skewed, a significant concern about focusing too much on the average run length (ARL) criterion is that we may miss some crucial information about a control chart’s performance. Thus it is important to investigate the entire run length distribution of a control chart for an in-depth understanding before implementing the chart in process monitoring. In this paper, the percentiles of the run length distribution for the double sampling (DS) X chart with estimated process parameters are computed. Knowledge of the percentiles of the run length distribution provides a more comprehensive understanding of the expected behaviour of the run length. This additional information includes the early false alarm, the skewness of the run length distribution, and the median run length (MRL). A comparison of the run length distribution between the optimal ARL-based and MRL-based DS X chart with estimated process parameters is presented in this paper. Examples of applications are given to aid practitioners to select the best design scheme of the DS X chart with estimated process parameters, based on their specific purpose

    Hydrodynamic Modes in a Trapped Strongly Interacting Fermi Gases of Atoms

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    The zero-temperature properties of a dilute two-component Fermi gas in the BCS-BEC crossover are investigated. On the basis of a generalization of the variational Schwinger method, we construct approximate semi-analytical formulae for collective frequencies of the radial and the axial breathing modes of the Fermi gas under harmonic confinement in the framework of the hydrodynamic theory. It is shown that the method gives nearly exact solutions.Comment: 11 page

    EXACT RUN LENGTH DISTRIBUTION OF THE DOUBLE SAMPLING X CHART WITH ESTIMATED PROCESS PARAMETERS

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    Since the run length distribution is generally highly skewed, a significant concern about focusing too much on the average run length (ARL) criterion is that we may miss some crucial information about a control chart’s performance. Thus it is important to investigate the entire run length distribution of a control chart for an in-depth understanding before implementing the chart in process monitoring. In this paper, the percentiles of the run length distribution for the double sampling (DS) X chart with estimated process parameters are computed. Knowledge of the percentiles of the run length distribution provides a more comprehensive understanding of the expected behaviour of the run length. This additional information includes the early false alarm, the skewness of the run length distribution, and the median run length (MRL). A comparison of the run length distribution between the optimal ARL-based and MRL-based DS X chart with estimated process parameters is presented in this paper. Examples of applications are given to aid practitioners to select the best design scheme of the DS X chart with estimated process parameters, based on their specific purpose

    A Review of Social-Aware Navigation Frameworks for Service Robot in Dynamic Human Environments

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    The emergence of service robot into human daily life in the past years has opened up various challenges including human-robot interaction, joint-goal achievement and machine learning. Social-aware navigation also gains vast research attention in enhancing the social capabilities of service robots. Human motions are stochastic and social conventions are very complex. Sophisticated approaches are needed for a robot to abide to these social rules and perform obstacle avoidance. To maintain the level of social comfort and achieve a given task, the robot navigation is now no longer a search for a shortest collision-free path, but a multi-objective problem that requires a unified social-aware navigation framework. A careful selection of navigation components including global planner, local planner, the prediction model and a suitable robot platform is also required to offer an effective navigation amidst the dynamic human environment. Hence, this review paper aims to offer insights for service robot implementation by highlighting four varieties of navigation frameworks, various navigation components and different robot platforms

    Mesoscale magnetism at the grain boundaries in colossal magnetoresistive films

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    We report the discovery of mesoscale regions with distinctive magnetic properties in epitaxial La1x_{1-x}Srx_{x}MnO3_{3} films which exhibit tunneling-like magnetoresistance across grain boundaries. By using temperature-dependent magnetic force microscopy we observe that the mesoscale regions are formed near the grain boundaries and have a different Curie temperature (up to 20 K {\it higher}) than the grain interiors. Our images provide direct evidence for previous speculations that the grain boundaries in thin films are not magnetically and electronically sharp interfaces. The size of the mesoscale regions varies with temperature and nature of the underlying defect.Comment: 4 pages of text, 4 figure

    The Hilbert-Schmidt Theorem Formulation of the R-Matrix Theory

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    Using the Hilbert-Schmidt theorem, we reformulate the R-matrix theory in terms of a uniformly and absolutely convergent expansion. Term by term differentiation is possible with this expansion in the neighborhood of the surface. Methods for improving the convergence are discussed when the R-function series is truncated for practical applications.Comment: 16 pages, Late

    Lattice-Boltzmann and finite-difference simulations for the permeability for three-dimensional porous media

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    Numerical micropermeametry is performed on three dimensional porous samples having a linear size of approximately 3 mm and a resolution of 7.5 μ\mum. One of the samples is a microtomographic image of Fontainebleau sandstone. Two of the samples are stochastic reconstructions with the same porosity, specific surface area, and two-point correlation function as the Fontainebleau sample. The fourth sample is a physical model which mimics the processes of sedimentation, compaction and diagenesis of Fontainebleau sandstone. The permeabilities of these samples are determined by numerically solving at low Reynolds numbers the appropriate Stokes equations in the pore spaces of the samples. The physical diagenesis model appears to reproduce the permeability of the real sandstone sample quite accurately, while the permeabilities of the stochastic reconstructions deviate from the latter by at least an order of magnitude. This finding confirms earlier qualitative predictions based on local porosity theory. Two numerical algorithms were used in these simulations. One is based on the lattice-Boltzmann method, and the other on conventional finite-difference techniques. The accuracy of these two methods is discussed and compared, also with experiment.Comment: to appear in: Phys.Rev.E (2002), 32 pages, Latex, 1 Figur
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