Orbifold resolutions with general profile

A very general class of resolved versions of the C/Z_N, T^2/Z_N and S^1/Z_2 orbifolds is considered and the free theory of 6D chiral fermions studied on it. As the orbifold limit is taken, localized 4D chiral massless fermions are seen to arise at the fixed points. Their number, location and chirality is found to be independent on the detailed profile of the resolving space and to agree with the result of hep-th/0409229, in which a particular resolution was employed. As a consistency check of the resolution procedure, the massive equation is numerically studied. In particular, for S^1/Z_2, the "resolved" mass--spectrum and wave functions in the internal space are seen to correctly reproduce the usual orbifold ones, as the orbifold limit is taken.Comment: 28 pages, 3 figures, typos corrected, references adde

Modulus stabilization of generalized Randall Sundrum model with bulk scalar field

We study the stabilization of inter-brane spacing modulus of generalized warped brane models with a nonzero brane cosmological constant. Employing Goldberger-Wise stabilization prescription of brane world models with a bulk scalar field, we show that the stabilized value of the modulus generally depends on the value of the brane cosmological constant. Our result further reveals that the stabilized modulus value corresponding to a vanishingly small cosmological constant can only resolve the gauge hierarchy problem simultaneously. This in turn vindicates the original Randall-Sundrum model where the 3-brane cosmological constant was chosen to be zero.Comment: 12 Pages, 1 figure, Revtex, Version to appear in Euro. Phys. Let

Design and Simulation of Extended Interaction Cavities for a Ka band Multi beam Klystron

This article reports about the design approach, electromagnetic simulation and analysis results of high-frequency ladder-type input, output, and intermediate RF cavaties for Ka-band multi-beam extended interaction klystron. Several parameters of the cavity, such as quality factor, shunt impedance, etc., have been investigated by the assistance of electromagnetic software CST microwave studio

Scalar Kaluza-Klein modes in a multiply warped braneworld

The Kaluza-Klein (KK) modes of a massive scalar field on a 3-brane embedded in six dimensional multiply warped spacetime are determined. Due to the presence of warping along both the extra dimensions the KK mass spectrum splits into two closely spaced branches which is a distinct feature of this model compared to the five dimensional Randall-Sundrum model. This new cluster of the KK mode spectrum is expected to have interesting phenomenological implications for the upcoming collider experiments. Such a scenario may also be extended for even larger number of orbifolded extra dimensions.Comment: 10 pages, Revte

de Sitter branes with a bulk scalar

We propose new braneworld models arising from a scalar field in the bulk. In these examples, the induced on--brane line element is de Sitter (or anti de Sitter) and the bulk (five dimensional) Einstein equations can be exactly solved to obtain warped spacetimes. The solutions thus derived are single and two-brane models -- one with {\em thin} branes while the other one of the {\em thick} variety. The field profiles and the potentials are obtained and analysed for each case. We note that for the {\em thick} brane scenario the field profile resembles a kink, whereas for one or more {\em thin} branes, it is finite and bounded in the domain of the extra dimension. We have also addressed the localisation of gravity and other matter fields on the brane for these braneworld models.Comment: 18 pages, 5 figures. Substantial changes and new results. To appear in GR

Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

BACKGROUND: In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate telomere shortening and cause replicative senescence and apoptotic cell death of tumor cells while having little or no effect on normal diploid cells. RESULTS: We designed siRNAs against two different regions of telomerase gene and evaluated their effect on telomere length, proliferative potential, and gene expression in Barrett's adenocarcinoma SEG-1 cells. The mixture of siRNAs in nanomolar concentrations caused a loss of telomerase activity that appeared as early as day 1 and was essentially complete at day 3. Inhibition of telomerase activity was associated with marked reduction in median telomere length and complete loss of detectable telomeres in more than 50% of the treated cells. Telomere loss caused senescence in 40% and apoptosis in 86% of the treated cells. These responses appeared to be associated with activation of DNA sensor HR23B and subsequent activation of p53 homolog p73 and p63 and E2F1. Changes in these gene regulators were probably the source of observed up-regulation of cell cycle inhibitors, p16 and GADD45. Elevated transcript levels of FasL, Fas and caspase 8 that activate death receptors and CARD 9 that interacts with Bcl10 and NFKB to enhance mitochondrial translocation and activation of caspase 9 were also observed. CONCLUSION: These studies show that telomerase siRNAs can cause effective suppression of telomerase and telomere shortening leading to both cell cycle arrest and apoptosis via mechanisms that include up-regulation of several genes involved in cell cycle arrest and apoptosis. Telomerase siRNAs may therefore be strong candidates for highly selective therapy for chemoprevention and treatment of Barrett's adenocarcinoma

Cosmology and Fermion Confinement in a Scalar-Field-Generated Domain Wall Brane in Five Dimensions

We consider a brane generated by a scalar field domain wall configuration in 4+1 dimensions, interpolating, in most cases, between two vacua of the field. We study the cosmology of such a system in the cases where the effective four-dimensional brane metric is de Sitter or anti de Sitter, including a discussion of the bulk coordinate singularities present in the de-Sitter case. We demonstrate that a scalar field kink configuration can support a brane with dS$_4$ cosmology, despite the presence of coordinate singularities in the metric. We examine the trapping of fermion fields on the domain wall for nontrivial brane cosmology.Comment: 29 pages, 12 figures; minor changes, accepted by JHE

Tobacco Mosaic Virus Based Thin Film Sensor for Detection of Volatile Organic Compounds

A thin film sensor for the detection of volatile organic compounds (VOC) was fabricated by deposition of oligo-aniline grafted tobacco mosaic virus (TMV) onto a glass substrate. The oligo-aniline motifs were conjugated onto the TMV surface by a traditional diazonium coupling reaction to tyrosine residues followed by Cu(I) catalyzed alkyne-azide cycloaddition (CuAAC) reaction. The modified TMV was easily fabricated into a thin film by directly drop coating onto a glass substrate. Upon integration of the glass substrate into a prototypical device, the virus-based thin film exhibited good sensitivity and selectivity toward ethanol and methanol vapour