A ‘healthy baby’: The double imperative of preimplantation genetic diagnosis

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 The Authors.This article reports from a study exploring the social processes, meanings and institutions that frame and produce ‘ethical problems’ and clinical dilemmas for practitioners, scientists and others working in the specialty of preimplantation genetic diagnosis (PGD). A major topic in the data was that, in contrast to IVF, the aim of PGD is to transfer to the woman’s womb only those embryos likely to be unaffected by serious genetic disorders; that is, to produce ‘healthy babies’. Staff described the complex processes through which embryos in each treatment cycle must meet a double imperative: they must be judged viable by embryologists and ‘unaffected’ by geneticists. In this article, we focus on some of the ethical, social and occupational issues for staff ensuing from PGD’s double imperative.The Wellcome Trus

Hormonal Regulation of AMPA Receptor Trafficking and Memory Formation

Humans and rodents retain memories for stressful events very well. The facilitated retention of these memories is normally very useful. However, in susceptible individuals a variety of pathological conditions may develop in which memories related to stressful events remain inappropriately present, such as in post-traumatic stress disorder. The memory enhancing effects of stress are mediated by hormones, such as norepinephrine and glucocorticoids which are released during stressful experiences. Here we review recently identified molecular mechanisms that underlie the effects of stress hormones on synaptic efficacy and learning and memory. We discuss AMPA receptors as major target for stress hormones and describe a model in which norepinephrine and glucocorticoids are able to strengthen and prolong different phases of stressful memories

Searching for hexagonal analogues of the half-metallic half-Heusler XYZ compounds

The XYZ half-Heusler crystal structure can conveniently be described as a tetrahedral zinc blende YZ structure which is stuffed by a slightly ionic X species. This description is well suited to understand the electronic structure of semiconducting 8-electron compounds such as LiAlSi (formulated Li$^+$[AlSi]$^-$) or semiconducting 18-electron compounds such as TiCoSb (formulated Ti$^{4+}$[CoSb]$^{4-}$). The basis for this is that [AlSi]$^-$ (with the same electron count as Si$_2$) and [CoSb]$^{4-}$ (the same electron count as GaSb), are both structurally and electronically, zinc-blende semiconductors. The electronic structure of half-metallic ferromagnets in this structure type can then be described as semiconductors with stuffing magnetic ions which have a local moment: For example, 22 electron MnNiSb can be written Mn$^{3+}$[NiSb]$^{3-}$. The tendency in the 18 electron compound for a semiconducting gap -- believed to arise from strong covalency -- is carried over in MnNiSb to a tendency for a gap in one spin direction. Here we similarly propose the systematic examination of 18-electron hexagonal compounds for semiconducting gaps; these would be the "stuffed wurtzite" analogues of the "stuffed zinc blende" half-Heusler compounds. These semiconductors could then serve as the basis for possibly new families of half-metallic compounds, attained through appropriate replacement of non-magnetic ions by magnetic ones. These semiconductors and semimetals with tunable charge carrier concentrations could also be interesting in the context of magnetoresistive and thermoelectric materials.Comment: 11 pages, 6 figures, of which 4 are colou

Comparative analysis of model behaviour for flood prediction purposes using Self-Organizing Maps

Distributed watershed models constitute a key component in flood forecasting systems. It is widely recognized that models because of their structural differences have varying capabilities of capturing different aspects of the system behaviour equally well. Of course, this also applies to the reproduction of peak discharges by a simulation model which is of particular interest regarding the flood forecasting problem. <br><br> In our study we use a Self-Organizing Map (SOM) in combination with index measures which are derived from the flow duration curve in order to examine the conditions under which three different distributed watershed models are capable of reproducing flood events present in the calibration data. These indices are specifically conceptualized to extract data on the peak discharge characteristics of model output time series which are obtained from Monte-Carlo simulations with the distributed watershed models NASIM, LARSIM and WaSIM-ETH. The SOM helps to analyze this data by producing a discretized mapping of their distribution in the index space onto a two dimensional plane such that their pattern and consequently the patterns of model behaviour can be conveyed in a comprehensive manner. It is demonstrated how the SOM provides useful information about details of model behaviour and also helps identifying the model parameters that are relevant for the reproduction of peak discharges and thus for flood prediction problems. It is further shown how the SOM can be used to identify those parameter sets from among the Monte-Carlo data that most closely approximate the peak discharges of a measured time series. The results represent the characteristics of the observed time series with partially superior accuracy than the reference simulation obtained by implementing a simple calibration strategy using the global optimization algorithm SCE-UA. The most prominent advantage of using SOM in the context of model analysis is that it allows to comparatively evaluating the data from two or more models. Our results highlight the individuality of the model realizations in terms of the index measures and shed a critical light on the use and implementation of simple and yet too rigorous calibration strategies

Multiple-Brain connectivity during third party punishment: an EEG hyperscanning study

Compassion is a particular form of empathic reaction to harm that befalls others and is accompanied by a desire to alleviate their suffering. This altruistic behavior is often manifested through altruistic punishment, wherein individuals penalize a deprecated human's actions, even if they are directed toward strangers. By adopting a dual approach, we provide empirical evidence that compassion is a multifaceted prosocial behavior and can predict altruistic punishment. In particular, in this multiple-brain connectivity study in an EEG hyperscanning setting, compassion was examined during real-time social interactions in a third-party punishment (TPP) experiment. We observed that specific connectivity patterns were linked to behavioral and psychological intra- and interpersonal factors. Thus, our results suggest that an ecological approach based on simultaneous dual-scanning and multiple-brain connectivity is suitable for analyzing complex social phenomena

Root and canal morphology of the mandibular first molar: A micro-computed tomography-focused observation of literature with illustrative cases. Part 1: External root morphology

The mandibular first molar often requires endodontic intervention, which can be challenging and complex with several variants in the number of canals and roots. Usually, these teeth have a single mesial and distal root, but variants and anomalies have been noted. The incidence of the number of roots can differ between populations. For instance, up to a third of East Asians present with a third root, while the global prevalence is 8.9%. One- and four-rooted first molar teeth are seldom encountered. Over the years different methods have been used to study root and canal morphology, but micro-computed tomography (micro-CT) has provided a non-invasive method to study root and canal morphology in high definition. This paperis the first of two giving an overview of available literature on various aspects of the external and internal root andcanal morphology of the mandibular first permanent molar. The aim is to provide an overview of relevant aspects of the external root morphology of the mandibular first molar in different populations. The content is supported by illustrative micro-CT images and a report on clinical cases where anomalies have been treated