Identification of stromal cells in spleen which support myelopoiesis

Stromal cells in spleen organize tissue into red pulp, white pulp and marginal zone, and also interact with hematopoietic cells to regulate immune responses. This study has used phenotypic information of a previously described spleen stromal cell line called 5G3, which supports restricted hematopoiesis in vitro, to identify an equivalent stromal cell subset in vivo and to test its capacity to support hematopoiesis. Using stromal cell fractionation, phenotypic analysis, as well as cell growth and hematopoietic support assays, the Sca-1+gp38+Thy1.2+CD29+CD51+ fraction of spleen stroma has been identified as an equivalent stromal subset resembling the 5G3 cell counterpart. While heterogeneity may still exist within that subset, it has been shown to have superior hematopoietic support capacity compared with the 5G3 cell line, and all other spleen stromal cell fractions tested.This work was supported by project grants to HO from the Australian Research Council (#DP130101703) and the National Health and Medical Research Council of Australia (#585443). HL was supported by an Australian National University Postgraduate Scholarship

Stress intensity at a crack between bonded dissimilar materials

The contour integral method is extended to general boundary value problems involving imperfect bonding of dissimilar materials. The loading and restraints are shown to have a significant effect on the stress intensity. Example problems are presented to illustrate the results

One-dimensional kinetic description of nonlinear traveling-pulse (soliton) and traveling-wave disturbances in long coasting charged particle beams

This paper makes use of a one-dimensional kinetic model to investigate the nonlinear longitudinal dynamics of a long coasting beam propagating through a perfectly conducting circular pipe with radius $r_{w}$. The average axial electric field is expressed as $\langle E_{z}\rangle=-(\partial/\partial z)\langle\phi\rangle=-e_{b}g_{0}\partial\lambda_{b}/\partial z-e_{b}g_{2}r_{w}^{2}\partial^{3}\lambda_{b}/\partial z^{3}$, where $g_{0}$ and $g_{2}$ are constant geometric factors, $\lambda_{b}(z,t)=\int dp_{z}F_{b}(z,p_{z},t)$ is the line density of beam particles, and $F_{b}(z,p_{z},t)$ satisfies the 1D Vlasov equation. Detailed nonlinear properties of traveling-wave and traveling-pulse (solitons) solutions with time-stationary waveform are examined for a wide range of system parameters extending from moderate-amplitudes to large-amplitude modulations of the beam charge density. Two classes of solutions for the beam distribution function are considered, corresponding to: (a) the nonlinear waterbag distribution, where $F_{b}=const.$ in a bounded region of $p_{z}$-space; and (b) nonlinear Bernstein-Green-Kruskal (BGK)-like solutions, allowing for both trapped and untrapped particle distributions to interact with the self-generated electric field $\langle E_{z}\rangle$. .Comment: 42 pages, 17 figure

Combined Effect of QCD Resummation and QED Radiative Correction to W boson Observables at the Tevatron

A precise determination of the W boson mass at the Fermilab Tevatron requires a theoretical calculation in which the effects of the initial-state multiple soft-gluon emission and the final-state photonic correction are simultaneously included . Here, we present such a calculation and discuss its prediction on the transverse mass distribution of the W boson and the transverse momentum distribution of its decay charged lepton, which are the most relevant observables for measuring the W boson mass at hadron colliders.Comment: 10 pages, 3 Postscript figures, uses revtex4.st