7 research outputs found
Design and study protocol of the maternal smoking cessation during pregnancy study, (M-SCOPE)
<p>Abstract</p> <p>Background</p> <p>Maternal smoking is the most significant cause of preventable complications during pregnancy, with smoking cessation during pregnancy shown to increase birth weight and reduce preterm birth among pregnant women who quit smoking. Taking into account the fact that the number of women who smoke in Greece has increased steadily throughout the previous decade and that the prevalence of smoking among Greek females is one of the highest in the world, smoking cessation should be a top priority among Greek health care professionals.</p> <p>Methods/Design</p> <p>The Maternal Smoking Cessation during Pregnancy Study (M-SCOPE), is a Randomized Control Trial (RCT) that aims to test whether offering Greek pregnant smokers a high intensity intervention increases smoking cessation during the third trimester of pregnancy, when compared to a low intensity intervention. Prospective participants will be pregnant smokers of more than 5 cigarettes per week, recruited up to the second trimester of pregnancy. Urine samples for biomarker analysis of cotinine will be collected at three time points: at baseline, at around the 32<sup>nd </sup>week of gestation and at six months post partum. The control group/low intensity intervention will include: brief advice for 5 minutes and a short leaflet, while the experimental group/intensive intervention will include: 30 minutes of individualized cognitive-behavioural intervention provided by a trained health professional and a self-help manual especially tailored for smoking cessation during pregnancy, while counselling will be based on the ''5 As.'' After childbirth, the infants' birth weight, gestational age and any other health related complications during pregnancy will be recorded. A six months post-partum a follow up will be performed in order to re-assess the quitters smoking status.</p> <p>Discussion</p> <p>If offering pregnant smokers a high intensity intervention for smoking cessation increases the rate of smoking cessation in comparison to a usual care low intensity intervention in Greek pregnant smokers, such a scheme if beneficial could be implemented successfully within clinical practice in Greece.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov Identifier <a href="http://www.clinicaltrials.gov/ct2/show/NCT01210118">NCT01210118</a></p
RETRACTED: Immunological factors and their role in the genesis and development of endometriosis (Retracted article. See vol. 35, pg. 390, 2009)
The article presents an overview of immunological factors and their role
in the genesis and development of endometriosis, with emphasis on
inflammatory cytokines and growth and adhesion factors. Although
retrograde menstruation is a common phenomenon among women of
reproductive age, not all women with retrograde menstruation suffer the
disease. Development of endometriosis seems to be a complex process,
facilitated by several factors, including quantity and quality of
endometrial cells in peritoneal fluid (PF), increased inflammatory
activity in PF, increased endometrial-peritoneal adhesion and
angiogenesis, reduced immune surveillance and clearance of endometrial
cells, and increased production of autoantibodies against endometrial
cells. Potential biomarkers like cytokines and autoantibodies,
upregulated during development of endometriosis, seem useful in the
development of a non-surgical diagnostic tool. In this review work, the
immune role in endometriosis is examined through the role of
immunological factors in the genesis and development of the disease.
Furthermore, it could be concluded that, although endometriosis can be
treated using hormonal suppression, there is a need today for
non-hormonal drugs, probably to modulate immune function, in order to
confront the disease and alleviate pain or infertility without
inhibition of ovulation