Gut bacteria and necrotizing enterocolitis: cause or effect?

Development of necrotising enterocolitis (NEC) is considered to be dependent on the bacterial colonisation of the gut. With little concordance between published data and a recent study failing to detect a common strain in infants with NEC, more questions than answers are arising about our understanding of this complex disease

A Framework for Evaluating Security in the Presence of Signal Injection Attacks

Sensors are embedded in security-critical applications from medical devices to nuclear power plants, but their outputs can be spoofed through electromagnetic and other types of signals transmitted by attackers at a distance. To address the lack of a unifying framework for evaluating the effects of such transmissions, we introduce a system and threat model for signal injection attacks. We further define the concepts of existential, selective, and universal security, which address attacker goals from mere disruptions of the sensor readings to precise waveform injections. Moreover, we introduce an algorithm which allows circuit designers to concretely calculate the security level of real systems. Finally, we apply our definitions and algorithm in practice using measurements of injections against a smartphone microphone, and analyze the demodulation characteristics of commercial Analog-to-Digital Converters (ADCs). Overall, our work highlights the importance of evaluating the susceptibility of systems against signal injection attacks, and introduces both the terminology and the methodology to do so.Comment: This article is the extended technical report version of the paper presented at ESORICS 2019, 24th European Symposium on Research in Computer Security (ESORICS), Luxembourg, Luxembourg, September 201

Relativistic entanglement of two massive particles

We describe the spin and momentum degrees of freedom of a system of two massive spin--$\tfrac{1}{2}$ particles as a 4 qubit system. Then we explicitly show how the entanglement changes between different partitions of the qubits, when considered by different inertial observers. Although the two particle entanglement corresponding to a partition into Alice's and Bob's subsystems is, as often stated in the literature, invariant under Lorentz boosts, the entanglement with respect to other partitions of the Hilbert space on the other hand, is not. It certainly does depend on the chosen inertial frame and on the initial state considered. The change of entanglement arises, because a Lorentz boost on the momenta of the particles causes a Wigner rotation of the spin, which in certain cases entangles the spin- with the momentum states. We systematically investigate the situation for different classes of initial spin states and different partitions of the 4 qubit space. Furthermore, we study the behavior of Bell inequalities for different observers and demonstrate how the maximally possible degree of violation, using the Pauli-Lubanski spin observable, can be recovered by any inertial observer.Comment: 17 pages, 4 figure

Optimization of the BLASTN substitution matrix for prediction of non-specific DNA microarray hybridization

DNA microarray measurements are susceptible to error caused by non-specific hybridization between a probe and a target (cross-hybridization), or between two targets (bulk-hybridization). Search algorithms such as BLASTN can quickly identify potentially hybridizing sequences. We set out to improve BLASTN accuracy by modifying the substitution matrix and gap penalties. We generated gene expression microarray data for samples in which 1 or 10% of the target mass was an exogenous spike of known sequence. We found that the 10% spike induced 2-fold intensity changes in 3% of the probes, two-third of which were decreases in intensity likely caused by bulk-hybridization. These changes were correlated with similarity between the spike and probe sequences. Interestingly, even very weak similarities tended to induce a change in probe intensity with the 10% spike. Using this data, we optimized the BLASTN substitution matrix to more accurately identify probes susceptible to non-specific hybridization with the spike. Relative to the default substitution matrix, the optimized matrix features a decreased score for A–T base pairs relative to G–C base pairs, resulting in a 5–15% increase in area under the ROC curve for identifying affected probes. This optimized matrix may be useful in the design of microarray probes, and in other BLASTN-based searches for hybridization partners

Lorentz invariance of entanglement classes in multipartite systems

We analyze multipartite entanglement in systems of spin-1/2 particles from a relativistic perspective. General conditions which have to be met for any classification of multipartite entanglement to be Lorentz invariant are derived, which contributes to a physical understanding of entanglement classification. We show that quantum information in a relativistic setting requires the partition of the Hilbert space into particles to be taken seriously. Furthermore, we study exemplary cases and show how the spin and momentum entanglement transforms relativistically in a multipartite setting.Comment: v2: 5 pages, 4 figures, minor changes to main body, journal references update

Trade-offs between precision and fluctuations in charging finite-dimensional quantum systems

Within quantum thermodynamics, many tasks are modelled by processes that require work sources represented by out-of-equilibrium quantum systems, often dubbed quantum batteries, in which work can be deposited or from which work can be extracted. Here we consider quantum batteries modelled as finite-dimensional quantum systems initially in thermal equilibrium that are charged via cyclic Hamiltonian processes. We present optimal or near-optimal protocols for $N$ identical two-level systems and individual $d$-level systems with equally spaced energy gaps in terms of the charging precision and work fluctuations during the charging process. We analyze the trade-off between these figures of merit as well as the performance of local and global operations.Comment: 14+2 pages, 7 figure