499 research outputs found
On the indistinguishability of Raman photons
We provide a theoretical framework to study the effect of dephasing on the
quantum indistinguishability of single photons emitted from a coherently driven
cavity QED -system. We show that with a large excited-state detuning,
the photon indistinguishability can be drastically improved provided that the
fluctuation rate of the noise source affecting the excited state is fast
compared with the photon emission rate. In some cases a spectral filter is
required to realize this improvement, but the cost in efficiency can be made
small.Comment: 18 pages, 3 figures, final versio
Flat Dielectric Grating Reflectors with High Focusing Power
Sub-wavelength dielectric gratings (SWG) have emerged recently as a promising
alternative to distributed-Bragg-reflection (DBR) dielectric stacks for
broadband, high-reflectivity filtering applications. A SWG structure composed
of a single dielectric layer with the appropriate patterning can sometimes
perform as well as thirty or forty dielectric DBR layers, while providing new
functionalities such as polarization control and near-field amplification. In
this paper, we introduce a remarkable property of grating mirrors that cannot
be realized by their DBR counterpart: we show that a non-periodic patterning of
the grating surface can give full control over the phase front of reflected
light while maintaining a high reflectivity. This new feature of dielectric
gratings could have a substantial impact on a number of applications that
depend on low-cost, compact optical components, from laser cavities to CD/DVD
read/write heads.Comment: submitted to Nature Photonic
GHZ extraction yield for multipartite stabilizer states
Let be an arbitrary stabilizer state distributed between three
remote parties, such that each party holds several qubits. Let be a
stabilizer group of . We show that can be converted by local
unitaries into a collection of singlets, GHZ states, and local one-qubit
states. The numbers of singlets and GHZs are determined by dimensions of
certain subgroups of . For an arbitrary number of parties we find a
formula for the maximal number of -partite GHZ states that can be extracted
from by local unitaries. A connection with earlier introduced measures
of multipartite correlations is made. An example of an undecomposable
four-party stabilizer state with more than one qubit per party is given. These
results are derived from a general theoretical framework that allows one to
study interconversion of multipartite stabilizer states by local Clifford group
operators. As a simple application, we study three-party entanglement in
two-dimensional lattice models that can be exactly solved by the stabilizer
formalism.Comment: 12 pages, 1 figur
Chronic neuropathic pain in spinal cord injury patients: What relevant additional clinical exams should be performed?
AbstractObjectiveStudy the indications and level of evidence of clinical exams that might be relevant in exploring the causes of neuropathic pain in spinal cord injury patients.MethodLiterature review from three databases: PubMed, Embase, Pascal.ResultsDisparity and heterogeneity of the answers given by the attendees to the experts conference of the French Society of Physical Medicine and Rehabilitation (SOFMER) and the physicians surveyed via the SOFMER website. These results corroborate the shortage of available data on this topic in the literature. From this analysis, we can however validate spinal MRI imaging as a mandatory exam for the diagnosis of post-traumatic syringomyelia (cystic myelopathy) – this exam can even be considered a Gold Standard. Furthermore, we can also recommend using electrodiagnostic studies for compressive neuropathies. However, it is not possible to validate the relevance of additional clinical exams for radicular pain, segmental deafferentation pain, central deafferentation pain as well as Complex Regional Pain Syndrome (CRPS) type 1; for these types of pain we can only formulate experts recommendations in light of the dearth of available data on the subject.ConclusionFor the neuropathic pain of spinal cord injury patients’ additional clinical exams should be used in the framework of an etiological diagnosis
Model Adaptation with Synthetic and Real Data for Semantic Dense Foggy Scene Understanding
This work addresses the problem of semantic scene understanding under dense
fog. Although considerable progress has been made in semantic scene
understanding, it is mainly related to clear-weather scenes. Extending
recognition methods to adverse weather conditions such as fog is crucial for
outdoor applications. In this paper, we propose a novel method, named
Curriculum Model Adaptation (CMAda), which gradually adapts a semantic
segmentation model from light synthetic fog to dense real fog in multiple
steps, using both synthetic and real foggy data. In addition, we present three
other main stand-alone contributions: 1) a novel method to add synthetic fog to
real, clear-weather scenes using semantic input; 2) a new fog density
estimator; 3) the Foggy Zurich dataset comprising real foggy images,
with pixel-level semantic annotations for images with dense fog. Our
experiments show that 1) our fog simulation slightly outperforms a
state-of-the-art competing simulation with respect to the task of semantic
foggy scene understanding (SFSU); 2) CMAda improves the performance of
state-of-the-art models for SFSU significantly by leveraging unlabeled real
foggy data. The datasets and code are publicly available.Comment: final version, ECCV 201
Les lésions médullaires traumatiques : épidémiologie et perspectives
AbstractObjectiveSpecify the epidemiological data on the acute spinal cord injuries and define a group of patients that could benefit from cellular transplantation therapy designed with the aim of repair and regeneration of damaged spinal cord tissues.Material and methodsFive years monocentric (Gui-de-Chauliac Hospital, Montpellier, France) retrospective analysis of patients suffering from spinal cord injury (SCI). Spinal cord injured-patients, defined as sensory-motor complete, underwent a clinical evaluation following American Spinal Injury Association (ASIA) and functional type 2 Spinal Cord Independence Measure (SCIM2) scorings as well as radiological evaluation through spinal cord magnetic resonance imaging (MRI).ResultsOne hundred and fifty-seven medical records were reviewed and we selected and re-examined 20 patients with complete thoracic spinal cord lesion. Clinical and radiological evaluations of these patients demonstrated, in 75 % of the cases, an absence of clinical progression after a mean of 49months. Radiological abnormalities were constantly present in the initial (at the admission to hospital) and control (re-evaluation) MRI and no reliable predictive criteria of prognosis had been found.Discussion/ConclusionWe compare our results to the literature and discuss advantages and limits of cellular transplantation strategies for these patients.RésuméObjectifsConnaître les données épidémiologiques de notre région sanitaire sur les traumatismes médullaires. Au sein de cette population, sélectionner les patients susceptibles de bénéficier de thérapie cellulaire dans la moelle épinière lésée dans l’objectif de régénérer le tissu nerveux. Évaluer à distance ces patients.Patients et méthodeAnalyse rétrospective de tous les patients pris en charge pour un traumatisme vertébro-médullaire. Réévaluation clinique et radiologique des patients présentant une atteinte médullaire thoracique sensitivomotrice complète. Réévaluation réalisée par le score de l’American Spinal Injury Association (ASIA), le score fonctionnel Type 2 Spinal Cord Independence Measure (SCIM2) et contrôle radiologique par une IRM médullaire.RésultatsCent cinquante-sept dossiers de patients ont été analysés et 28 patients présentaient une lésion médullaire complète. Une évaluation clinique et radiologique réalisée chez 20 patients sur 28 (71 %) a montré l’absence d’évolution clinique dans 75 % des cas dans un délai moyen de 49 mois. Les anomalies radiologiques étaient présentes dans 100 % des cas sur l’IRM initiale et de contrôle sans qu’aucun critère fiable prédictif de bon pronostic n’est retrouvé.Discussion/conclusionNous présentons ces résultats comparativement à ceux de la littérature et nous discutons chez ces malades les stratégies de transplantation cellulaire, leurs limites actuelles et les progrès nécessaires pour obtenir des résultats
Protection against Clostridium difficile infection in a hamster model by oral vaccination using flagellin FliC-loaded pectin beads
International audienceClostridium difficile flagellin FliC is a highly immunogenic pathogen-associated molecular pattern playing a key role in C. difficile pathogenesis and gut colonization. Here, we designed an oral vaccine against C. difficile with FliC encapsulated into pectin beads for colonic release. Bead stability and FliC retention was confirmed in vitro using simulated intestinal media (SIM), while bead degradation and FliC release was observed upon incubation in simulated colonic media (SCM). The importance of FliC encapsulation into pectin beads for protection against C. difficile was assessed in a vaccination assay using a lethal ham-ster model of C. difficile infection. Three groups of hamsters orally received either FliC-loaded beads or unloaded beads in gastro-resistant capsule to limit gastric degradation or free FliC. Two other groups were immunized with free FliC, one intra-rectally and the other intra-peritoneally. Hamsters were then challenged with a lethal dose of C. difficile VPI 10463. Fifty percent of hamsters orally immunized with FliC-loaded beads survived whereas all hamsters orally immunized with free FliC died within 7 days post challenge. No significant protection was observed in the other groups. Only intra-peritoneally immunized hamsters presented anti-FliC IgG antibodies in sera after immunizations. These results suggest that an oral immunization with FliC-loaded beads probably induced a mucosal immune response, therefore providing a protective effect. This study confirms the importance of FliC encapsulation into pectin beads for a protective oral vaccine against C. difficile
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