1,741 research outputs found
Scaling of heat transfer augmentation due to mechanical distortions in hypervelocity boundary layers
IN-SYNC. V. Stellar kinematics and dynamics in the Orion A Molecular Cloud
The kinematics and dynamics of young stellar populations enable us to test
theories of star formation. With this aim, we continue our analysis of the
SDSS-III/APOGEE IN-SYNC survey, a high resolution near infrared spectroscopic
survey of young clusters. We focus on the Orion A star-forming region, for
which IN-SYNC obtained spectra of stars. In Paper IV we used these
data to study the young stellar population. Here we study the kinematic
properties through radial velocities (). The young stellar population
remains kinematically associated with the molecular gas, following a
gradient along filament. However, near the center
of the region, the distribution is slightly blueshifted and asymmetric;
we suggest that this population, which is older, is slightly in foreground. We
find evidence for kinematic subclustering, detecting statistically significant
groupings of co-located stars with coherent motions. These are mostly in the
lower-density regions of the cloud, while the ONC radial velocities are
smoothly distributed, consistent with it being an older, more dynamically
evolved cluster. The velocity dispersion varies along the filament.
The ONC appears virialized, or just slightly supervirial, consistent with an
old dynamical age. Here there is also some evidence for on-going expansion,
from a --extinction correlation. In the southern filament, is
-- times larger than virial in the L1641N region, where we infer a
superposition along the line of sight of stellar sub-populations, detached from
the gas. On the contrary, decreases towards L1641S, where the
population is again in agreement with a virial state.Comment: 14 pages, 13 figures, ApJ accepte
Functional status after blast-plus-impact complex concussive traumatic brain injury in evacuated United States military personnel
Fundamental questions remain unanswered about the longitudinal impact of blast-plus-impact complex traumatic brain injuries (TBI) from wars in Iraq and Afghanistan. This prospective, observational study investigated measures of clinical outcome in US military personnel evacuated to Landstuhl Regional Medical Center (LRMC) in Germany after such âblast-plusâ concussive TBIs. Glasgow Outcome Scale-Extended assessments completed 6â12 months after injury indicated a moderate overall disability in 41/47 (87%) blast-plus TBI subjects and a substantial but smaller number (11/18, 61%, p=0.018) of demographically similar US military controls without TBI evacuated for other medical reasons. Cognitive function assessed with a neuropsychological test battery was not different between blast-plus TBI subjects and controls; performance of both groups was generally in the normal range. No subject was found to have focal neurological deficits. However, 29/47 (57%) of blast-plus subjects with TBI met all criteria for post-traumatic stress disorder (PTSD) versus 5/18 (28%) of controls (p=0.014). PTSD was highly associated with overall disability; 31/34 patients with PTSD versus 19/31 patients who did not meet full PTSD criteria had moderate to severe disability (p=0.0003). Symptoms of depression were also more severe in the TBI group (p=0.05), and highly correlated with PTSD severity (r=0.86, p<0.0001). Thus, in summary, high rates of PTSD and depression but not cognitive impairment or focal neurological deficits were observed 6â12 months after concussive blast-plus-impact complex TBI. Overall disability was substantially greater than typically reported in civilian non-blast concussive (âmildâ) patients with TBI, even with polytrauma. The relationship between these clinical outcomes and specific blast-related aspects of brain injuries versus other combat-related factors remains unknown
ALMA 1.3 Millimeter Map of the HD 95086 System
Planets and minor bodies such as asteroids, Kuiper-belt objects and comets
are integral components of a planetary system. Interactions among them leave
clues about the formation process of a planetary system. The signature of such
interactions is most prominent through observations of its debris disk at
millimeter wavelengths where emission is dominated by the population of large
grains that stay close to their parent bodies. Here we present ALMA 1.3 mm
observations of HD 95086, a young early-type star that hosts a directly imaged
giant planet b and a massive debris disk with both asteroid- and Kuiper-belt
analogs. The location of the Kuiper-belt analog is resolved for the first time.
The system can be depicted as a broad (0.84), inclined
(30\arcdeg3\arcdeg) ring with millimeter emission peaked at 2006 au
from the star. The 1.3 mm disk emission is consistent with a broad disk with
sharp boundaries from 1066 to 32020 au with a surface density
distribution described by a power law with an index of --0.50.2. Our deep
ALMA map also reveals a bright source located near the edge of the ring, whose
brightness at 1.3 mm and potential spectral energy distribution are consistent
with it being a luminous star-forming galaxy at high redshift. We set
constraints on the orbital properties of planet b assuming co-planarity with
the observed disk.Comment: accepted for publication in A
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Using a runway paradigm to assess the relative strength of rats' motivations for enrichment objects
Laboratory animals should be provided with enrichment objects in their cages; however, it is first necessary to
test whether the proposed enrichment objects provide benefits that increase the animalsâ welfare. The two main
paradigms currently used to assess proposed enrichment objects are the choice test, which is limited to determining
relative frequency of choice, and consumer demand studies, which can indicate the strength of a preference but are complex to design. Here, we propose a third methodology: a runway paradigm, which can be used to assess the strength of an animalâs motivation for enrichment objects, is simpler to use than consumer demand studies, and is faster to complete than typical choice tests. Time spent with objects in a standard choice test was used to rank several enrichment objects in order to compare with the ranking found in our runway paradigm. The rats ran significantly more times, ran faster, and interacted longer with objects with which they had previously spent the most time. It was concluded that this simple methodology is suitable for measuring ratsâ motivation to reach enrichment objects. This can be used to assess the preference for different types of enrichment objects or to measure reward system processes
NCI-MATCH Arms N & P: Phase II study of PI3K beta inhibitor GSK2636771 in patients (pts) with cancers (ca) with PTEN mutation/deletion (mut/del) or PTEN protein loss
Background: The NCI-MATCH trial is the largest national study (1173 sites) for ptswith relapsed/ refractory solid tumors, lymphomas and myeloma, which assigns tar-geted therapies based on individual tumor molecular alterations detected using theadapted Oncomine AmpliSeq panel (143 genes) and immunohistochemistry (IHC).We hypothesized that patients with PTEN-deficient cancers enrolled to Arms N and Pmay benefit from treatment with the PI3K beta-selective inhibitor GSK2636771.
Methods: Eligibility: relapsed/refractory ca, good end-organ function, and ECOG PSâ
â€â
1. Pts were screened for molecular alterations by centralized testing on fresh tumor biopsy and had deleterious PTEN mut/del without loss of expression (Arm N) or complete loss of cytoplasmic and nuclear PTEN staining on IHC (Arm P), and no other aberrations activating the PI3K/MTOR and MAPK pathways (mut in PIK3CA, PIK3R1, BRAF, KRAS, AKT1, TSC1/2, mTOR, RHEB, NF2, NRAS, HRAS). Pts received GSK2636771 400mg/day (28-days cycles). RECIST 1.1 overall response rate (ORR) was the primary endpoint.
Results: Of 59 enrolled pts, 56 were eligible and received treatment. Of 22 pts with PTEN mut/del (Arm N: 6 uterine, 2 breast, 2 prostate, 2 head/neck ca, 10 other), all are off treatment as of analysis (14 disease progression, 4 for adverse events [AEs], 4 other). One pt (4.5%) with prostate ca (PTEN deletion, MPRSS2-ERG fusion) attained a partial response (-42%). Of 7 (32%) pts with stable disease (SD), 2 had SDâ
\u3eâ
6 months (uterine leiomyosarcoma; endometrial carcinoma). Of 34 pts with loss of PTEN protein by IHC (Arm P: 7 prostate, 6 breast, 3 squamous anal ca, 2 cholangiocarcinoma, 16 other), all are off treatment as of analysis (26 disease progression, 4 for AE, 4 other). Of 9 (37.5%) pts with SD, 3 had SDâ
\u3eâ
6 months (prostate cancer; squamous bladder cancer, squamous anal cancer). Median progression-free survival was 1.8 months for both arms. Grâ
â„â
3 treatment-related (tr) reversible toxicities were experienced by 30% (7) and 20% (7) of pts in arms N and P, respectively. No tr Gr 5 toxicities were observed in either arm.
Conclusions: Single agent GSK2636771 has very modest activity in ca with PTEN gene mutation/deletion and/or PTEN protein loss
Lifting the Dusty Veil II: A Large-Scale Study of the Galactic Infrared Extinction Law
We combine near-infrared (2MASS) and mid-infrared (Spitzer-IRAC) photometry
to characterize the IR extinction law (1.2-8 microns) over nearly 150 degrees
of contiguous Milky Way midplane longitude. The relative extinctions in 5
passbands across these wavelength and longitude ranges are derived by
calculating color excess ratios for G and K giant red clump stars in contiguous
midplane regions and deriving the wavelength dependence of extinction in each
one. Strong, monotonic variations in the extinction law shape are found as a
function of angle from the Galactic center, symmetric on either side of it.
These longitudinal variations persist even when dense interstellar regions,
known a priori to have a shallower extinction curve, are removed. The
increasingly steep extinction curves towards the outer Galaxy indicate a steady
decrease in the absolute-to-selective extinction ratio (R_V) and in the mean
dust grain size at greater Galactocentric angles. We note an increasing
strength of the 8 micron extinction inflection at high Galactocentric angles
and, using theoretical dust models, show that this behavior is consistent with
the trend in R_V. Along several lines of sight where the solution is most
feasible, A_lambda/A_Ks as a function of Galactic radius is estimated and shown
to have a Galactic radial dependence. Our analyses suggest that the observed
relationship between extinction curve shape and Galactic longitude is due to an
intrinsic dependence of the extinction law on Galactocentric radius.Comment: Accepted to Ap
From a certain point of view: sensory phenomenological envisionings of running space and place
The precise ways in which we go about the mundane, repetitive, social actions of everyday life are central concerns of ethnographers and theorists working within the traditions of the sociology of the mundane and sociological phenomenology. In this article, we utilize insights derived from sociological phenomenology and the newly developing field of sensory sociology to investigate a particular, mundane, and embodied social practice, that of training for distance running in specific places: our favored running routes. For, despite a growing body of ethnographic studies of particular sports, little analytic attention has been devoted to the actual, concrete practices of âdoingâ or âproducingâ sporting activity, particularly from a sensory ethnographic perspective. Drawing upon data from a 2-year joint autoethnographic research project, here we explore the visual dimension, focusing upon three key themes in relation to our runnersâ visualization of, respectively, (1) hazardous places, (2) performance places, (3) the timeâspaceâplace nexus
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