6,373 research outputs found
New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction
ObjectivesLegg–Calvé–Perthes’ disease (LCP) is an idiopathic osteonecrosis of the femoral head that is most common in children between four and eight years old. The factors that lead to the onset of LCP are still unclear; however, it is believed that interruption of the blood supply to the developing epiphysis is an important factor in the development of the condition.MethodsFinite element analysis modelling of the blood supply to the juvenile epiphysis was investigated to understand under which circumstances the blood vessels supplying the femoral epiphysis could become obstructed. The identification of these conditions is likely to be important in understanding the biomechanics of LCP.ResultsThe results support the hypothesis that vascular obstruction to the epiphysis may arise when there is delayed ossification and when articular cartilage has reduced stiffness under compression.ConclusionThe findings support the theory of vascular occlusion as being important in the pathophysiology of Perthes disease
An Intelligent Multicriteria Model for Diagnosing Dementia in People Infected with Human Immunodeficiency Virus
Hybrid models to detect dementia based on Machine Learning can provide accurate
diagnoses in individuals with neurological disorders and cognitive complications caused by Human
Immunodeficiency Virus (HIV) infection. This study proposes a hybrid approach, using Machine
Learning algorithms associated with the multicriteria method of Verbal Decision Analysis (VDA).
Dementia, which affects many HIV-infected individuals, refers to neurodevelopmental and mental
disorders. Some manuals standardize the information used in the correct detection of neurological
disorders with cognitive complications. Among the most common manuals used are the DSM-5
(Diagnostic and Statistical Manual of Mental Disorders, 5th edition) of the American Psychiatric
Association and the International Classification of Diseases, 10th edition (ICD-10)—both published
byWorld Health Organization (WHO). The model is designed to explore the predictive of specific
data. Furthermore, a well-defined database data set improves and optimizes the diagnostic models
sought in the research.info:eu-repo/semantics/publishedVersio
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