144 research outputs found
Diffused vorticity approach to the oscillations of a rotating Bose-Einstein condensate confined in a harmonic plus quartic trap
The collective modes of a rotating Bose-Einstein condensate confined in an
attractive quadratic plus quartic trap are investigated. Assuming the presence
of a large number of vortices we apply the diffused vorticity approach to the
system. We then use the sum rule technique for the calculation of collective
frequencies, comparing the results with the numerical solution of the
linearized hydrodynamic equations. Numerical solutions also show the existence
of low-frequency multipole modes which are interpreted as vortex oscillations.Comment: 10 pages, 4 figure
Early marker of ocular neurodegeneration in children and adolescents with type 1 diabetes: the contributing role of polymorphisms in mir146a and mir128a genes
Background: Early ocular neurodegenerative signs of diabetic neuropathy (DN) can be found in children and adolescents with type 1 diabetes (T1D). No data are available on the potential role of polymorphisms in miRNAs genes in predisposing T1D subjects to these signs. Aims: To determine whether MIR146A rs2910164 and MIR128A rs11888095 polymorphisms are associated with early retinal and corneal neurodegenerative changes in pediatric patients with T1D. Methods: A total of 140 T1D children/adolescents underwent spectral domain-optical coherence tomography (SD-OCT) and in vivo confocal microscopy (IVCM) with measurement of retinal and corneal nerve fiber parameters. Risk factors for diabetes complications (diabetes duration, blood pressure, HbA1c) were recorded. Genotyping of rs2910164 and rs1188095 SNPs and genotype-phenotype association analysis were performed. Results: The C allele of rs2910164 in MIR146A was associated with higher values of IVCM parameters and minimum rim width (MRW) of the peripapillary region of optic nerve head measured in the retina, whereas the T allele of rs1188095 in MIR128A was associated with a significant impairment of them. Multiple regression analysis showed that MIR146A and MIR128A polymorphisms were significantly associated with corneal nerve fiber length (beta = 0.225 and - 0.204, respectively) and other IVCM parameters, independently from age, diabetes duration, HbA1c and systolic blood pressure percentile. Similar results were found for MRW (beta = 0.213 and - 0.286, respectively). Conclusions: These results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN
The CRESST Experiment: Recent Results and Prospects
The CRESST experiment seeks hypothetical WIMP particles that could account
for the bulk of dark matter in the Universe. The detectors are cryogenic
calorimeters in which WIMPs would scatter elastically on nuclei, releasing
phonons. The first phase of the experiment has successfully deployed several
262 g sapphire devices in the Gran Sasso underground laboratories. A main
source of background has been identified as microscopic mechanical fracturing
of the crystals, and has been eliminated, improving the background rate by up
to three orders of magnitude at low energies, leaving a rate close to one count
per day per kg and per keV above 10 keV recoil energy. This background now
appears to be dominated by radioactivity, and future CRESST scintillating
calorimeters which simultaneously measure light and phonons will allow
rejection of a great part of it.Comment: To appear in the proceedings of the CAPP2000 Conference, Verbier,
Switzerland, July, 2000 (eds J. Garcia-Bellido, R. Durrer, and M.
Shaposhnikov
The CRESST Dark Matter Search
We present first competitive results on WIMP dark matter using the
phonon-light-detection technique. A particularly strong limit for WIMPs with
coherent scattering results from selecting a region of the phonon-light plane
corresponding to tungsten recoils. The observed count rate in the neutron band
is compatible with the rate expected from neutron background. CRESST is
presently being upgraded with a 66 channel SQUID readout system, a neutron
shield and a muon veto system. This results in a significant improvement in
sensitivity.Comment: 6 pages, 3 figures, to be published in the proceedings of the 5th
International Workshop on the Identification and Detection of Dark Matter IDM
2004, Edinburgh, Sept. 2004, World Scientifi
Scissors mode of trapped dipolar gases
We study the scissors modes of dipolar boson and fermion gases trapped in a
spherically symmetric potential. We use the harmonic oscillator states to solve
the time-dependent Gross-Pitaevskii equation for bosons and the time-dependent
Hartree-Fock equation for fermions. It is pointed out that the scissors modes
of bosons and fermions can be of quite different nature
Detection of the Natural Alpha Decay of Tungsten
The natural alpha decay of 180W has been unambiguously detected for the first
time. The alpha peak is found in a (gamma,beta and neutron)-free background
spectrum. This has been achieved by the simultaneous measurement of phonon and
light signals with the CRESST cryogenic detectors. A half-life of T1/2 = (1.8
+- 0.2) x 10^18 y and an energy release of Q = (2516.4 +- 1.1 (stat.) +- 1.2
(sys.)) keV have been measured. New limits are also set on the half-lives of
the other naturally occurring tungsten isotopes.Comment: Submitted to Physical Review C Revised versio
Rational design of a user-friendly aptamer/peptide-based device for the detection of staphylococcus aureus
The urgent need to develop a detection system for Staphylococcus aureus, one of the most common causes of infection, is prompting research towards novel approaches and devices, with a particular focus on point-of-care analysis. Biosensors are promising systems to achieve this aim. We coupled the selectivity and affinity of aptamers, short nucleic acids sequences able to recognize specific epitopes on bacterial surface, immobilized at high density on a nanostructured zirconium dioxide surface, with the rational design of specifically interacting fluorescent peptides to assemble an easy-to-use detection device. We show that the displacement of fluorescent peptides upon the competitive binding of S. aureus to immobilized aptamers can be detected and quantified through fluorescence loss. This approach could be also applied to the detection of other bacterial species once aptamers interacting with specific antigens will be identified, allowing the development of a platform for easy detection of a pathogen without requiring access to a healthcare environment
Polytetrahedral Clusters
By studying the structures of clusters bound by a model potential that
favours polytetrahedral order, we find a previously unknown series of `magic
numbers' (i.e. sizes of special stability) whose polytetrahedral structures are
characterized by disclination networks that are analogous to hydrocarbons.Comment: 4 pages, 4 figure
Self-similar expansion of the density profile in a turbulent Bose-Einstein condensate
In a recent study we demonstrated the emergence of turbulence in a trapped
Bose-Einstein condensate of Rb-87 atoms. An intriguing observation in such a
system is the behavior of the turbulent cloud during free expansion.The aspect
ratio of the cloud size does not change in the way one would expect for an
ordinary non-rotating (vortex-free) condensate. Here we show that the anomalous
expansion can be understood, at least qualitatively, in terms of the presence
of vorticity distributed throughout the cloud, effectively counteracting the
usual reversal of the aspect ratio seen in free time-of-flight expansion of
non-rotating condensates.Comment: 8 pages, 4 figure
Applying an Empirical Hydropathic Forcefield in Refinement May Improve Low-Resolution Protein X-Ray Crystal Structures
BACKGROUND: The quality of X-ray crystallographic models for biomacromolecules refined from data obtained at high-resolution is assured by the data itself. However, at low-resolution, >3.0 Å, additional information is supplied by a forcefield coupled with an associated refinement protocol. These resulting structures are often of lower quality and thus unsuitable for downstream activities like structure-based drug discovery. METHODOLOGY: An X-ray crystallography refinement protocol that enhances standard methodology by incorporating energy terms from the HINT (Hydropathic INTeractions) empirical forcefield is described. This protocol was tested by refining synthetic low-resolution structural data derived from 25 diverse high-resolution structures, and referencing the resulting models to these structures. The models were also evaluated with global structural quality metrics, e.g., Ramachandran score and MolProbity clashscore. Three additional structures, for which only low-resolution data are available, were also re-refined with this methodology. RESULTS: The enhanced refinement protocol is most beneficial for reflection data at resolutions of 3.0 Å or worse. At the low-resolution limit, ≥4.0 Å, the new protocol generated models with Cα positions that have RMSDs that are 0.18 Å more similar to the reference high-resolution structure, Ramachandran scores improved by 13%, and clashscores improved by 51%, all in comparison to models generated with the standard refinement protocol. The hydropathic forcefield terms are at least as effective as Coulombic electrostatic terms in maintaining polar interaction networks, and significantly more effective in maintaining hydrophobic networks, as synthetic resolution is decremented. Even at resolutions ≥4.0 Å, these latter networks are generally native-like, as measured with a hydropathic interactions scoring tool
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