Analysing long-term interactions between demand response and different electricity markets using a stochastic market equilibrium model. ESRI WP585, February 2018

Power systems based on renewable energy sources (RES) are characterised by increasingly distributed, volatile and uncertain supply leading to growing requirements for flexibility. In this paper, we explore the role of demand response (DR) as a source of flexibility that is considered to become increasingly important in future. The majority of research in this context has focussed on the operation of power systems in energy only markets, mostly using deterministic optimisation models. In contrast, we explore the impact of DR on generator investments and profits from different markets, on costs for different consumers from different markets, and on CO2 emissions under consideration of the uncertainties associated with the RES generation. We also analyse the effect of the presence of a feed-in premium (FIP) for RES generation on these impacts. We therefore develop a novel stochastic mixed complementarity model in this paper that considers both operational and investment decisions, that considers interactions between an energy market, a capacity market and a feed-in premium and that takes into account the stochasticity of electricity generation by RES. We use a Benders decomposition algorithm to reduce the computational expenses of the model and apply the model to a case study based on the future Irish power system. We find that DR particularly increases renewable generator profits. While DR may reduce consumer costs from the energy market, these savings may be (over)compensated by increasing costs from the capacity market and the feed-in premium. This result highlights the importance of considering such interactions between different markets

4',5',6',7'-Tetrachlorospiro[cyclohex-2-ene-1,2'-indan]-1',3'-dione

The title compound, C₁₄H₈Cl₄O₂, has been isolated following irradiation of a dichloromethane solution of N-acetyltetrachlorophthalimide and cyclohexene. The structure refinement is slightly compromised by the disorder over two positions of equal occupancy of a methylene groupβ to the spiro C atom

Benzylammonium 2,4-bis(dicyanomethylene)-2,3-dihydroisoindolide

The cation and anion of the title salt, C⁷H₁₀N⁺.C₁₄H₄N₅-, are both bisected by a crystallographic mirror plane. Extensive hydrogen bonding, with the R₆⁶(28) graph-set motif, connects the ions into layers

(1RS,2SR,7RS,8RS)-N-Benzoyltricyclo[6.2.2.0²,⁷]dodeca-9,11-diene-1,10-dicarboximide

The title 1,4-photoadduct, C₂₁H₁₉NO₃, was formed on irradiation of N-benzoylphthalimide in dichloromethane containing cyclohexene. The bond lengths and angles are generally within the normal ranges. A notable feature of the molecule is the presence within it of four contiguous chiral centres

Iron Deficiency Anemia: An Unexpected Cause of an Acute Occipital Lobe Stroke in an Otherwise Healthy Young Woman

A 29-year-old caucasian woman who presented to the hospital with an acute onset of right eye visual disturbance and headache was found to have an acute left occipital lobe infarction. Past medical history was significant for iron deficiency anemia (IDA) secondary to menorrhagia. Her initial hemoglobin level was 7.8 G/DL, and her symptoms improved after iron and blood transfusions. Hypercoagulable studies were completed in the outpatient setting, and the results were unremarkable. Her acute stroke was most likely related to IDA as she had low cardiovascular risk factors along with a negative complete stroke workup

Looking for Life

The topic of aliens is not just about conspiracy theories and tinfoil hats, through the years numerous respected scientists have weighed in and put thought into the topic. The Search for Extraterrestrial Intelligence (SETI) is closely tied to the Fermi Paradox and the Drake Equation. The Fermi Paradox considers why humans haven\u27t already interacted with aliens if they exist, and the Drake Equation outlines potential variables that would influence the chances of humanity receiving radio contact from an alien civilization

Non-canonical cell signaling actions of pregnenolone sulfate, a neurosteroid that increases intracellular calcium, activates creb phosphorylation and stimulates trafficking of NMDA receptors to the surface of neurons

Preclinical results support the use of N-methyl D-aspartate receptor (NMDAR) modulators for cognition enhancement therapeutics. Pregnenolone sulfate (PregS) is a neuroactive steroid derived from cholesterol that augments long term potentiation (LTP) in hippocampal slices and improves memory performance in rats and mice. At micromolar concentrations, PregS is a subtype selective positive allosteric modulator of NMDARs at NR2A and NR2B containing receptors, and at concentrations ranging from pM - nM induces NMDAR-dependent dopamine release in the striatum and from striatal synaptosomes. In this report, we observe that micromolar [PregS] induces an increase in levels of neuronal intracellular calcium ([Ca^2+]i) and surface NMDARs in cortical neurons. Moreover, our results show that PregS stimulated upregulation of surface NR1 subunits in cortical neurons is dependent on NMDARs but independent of channel activity. As PregS has been detected in brain at bulk concentrations of 0.1 nM to 5 nM, we asked whether low, picomolar concentrations of PregS might alter [Ca^2+] levels. We report here that PregS increases [Ca^2+]i signal in cortical neurons in a voltage-gated Na^+ channel and NMDAR-NR2B dependent manner with an EC50 of ~2 pM, at least 6 orders of magnitude higher affinity than its rapid potentiating effect upon the NMDAR-mediated ionotropic response, and within the range of PregS detected in bulk brain tissue. Additionally, calcium (Ca^2+) activation of cyclic AMP response element binding protein (CREB) is critical to the protein synthesis-dependent component of LTP and important in associated behavioral measures of learning and memory. Increased [Ca^2+]i levels are known to induce CREB activation and we now show that 50 pM PregS induces a 44 ± 13% increase in the ratio of pCREB to total CREB that is dependent upon ERK signaling and canonical excitatory synaptic transmission: this includes voltage gated Na+ channels, NMDARs, and voltage-gated Ca^2+ channel activation. The results taken together indicate that PregS may be a useful platform for the development of high-affinity positive modulators of NMDAR-signaling that can be used as cognitive enhancers to treat a variety of neurological disorders: such as Alzheimer's disease, Parkinson's disease, and schizophrenia

The role of financing frictions in agricultural investment decisions: an analysis pre and post financial crisis

This paper uses a fundamental Q model of investment to consider the role played by financing frictions in agricultural investment decisions, controlling econometrically for censoring, heterogeneity and errors-in-variables. Our findings suggest that farmer's investment decisions are not driven by market fundamentals. We find some evidence that debt overhang restricts investment but investment is not dependent on liquidity or internal funds. The role of financing frictions in determining investment decisions changes in the post-financial crisis period when debt overhang becomes a significant impediment to farm investment. The evidence suggests that farmers increasingly rely on internal liquidity to drive investment. Finally, we find no evidence that farmers use on-farm capital to fund on-farm investment.Credit Constraints, Firm Level Investment, Tobin's Q, Debt, Agricultural Finance, G31, G32, F34,