507 research outputs found
Electrical switching of magnetic polarity in a multiferroic BiFeO3 device at room temperature
We have directly imaged reversible electrical switching of the cycloidal
rotation direction (magnetic polarity) in a (111)-BiFeO3 epitaxial-film device
at room temperature by non-resonant x-ray magnetic scattering. Consistent with
previous reports, fully relaxed (111)-BiFeO3 epitaxial films consisting of a
single ferroelectric domain were found to comprise a sub-micron-scale mosaic of
magneto-elastic domains, all sharing a common direction of the magnetic
polarity, which was found to switch reversibly upon reversal of the
ferroelectric polarization without any measurable change of the magneto-elastic
domain population. A real-space polarimetry map of our device clearly
distinguished between regions of the sample electrically addressed into the two
magnetic states with a resolution of a few tens of micron. Contrary to the
general belief that the magneto-electric coupling in BiFeO3 is weak, we find
that electrical switching has a dramatic effect on the magnetic structure, with
the magnetic moments rotating on average by 90 degrees at every cycle.Comment: 6 pages, 5 figures; corrected figure
Collective emotions online and their influence on community life
E-communities, social groups interacting online, have recently become an
object of interdisciplinary research. As with face-to-face meetings, Internet
exchanges may not only include factual information but also emotional
information - how participants feel about the subject discussed or other group
members. Emotions are known to be important in affecting interaction partners
in offline communication in many ways. Could emotions in Internet exchanges
affect others and systematically influence quantitative and qualitative aspects
of the trajectory of e-communities? The development of automatic sentiment
analysis has made large scale emotion detection and analysis possible using
text messages collected from the web. It is not clear if emotions in
e-communities primarily derive from individual group members' personalities or
if they result from intra-group interactions, and whether they influence group
activities. We show the collective character of affective phenomena on a large
scale as observed in 4 million posts downloaded from Blogs, Digg and BBC
forums. To test whether the emotions of a community member may influence the
emotions of others, posts were grouped into clusters of messages with similar
emotional valences. The frequency of long clusters was much higher than it
would be if emotions occurred at random. Distributions for cluster lengths can
be explained by preferential processes because conditional probabilities for
consecutive messages grow as a power law with cluster length. For BBC forum
threads, average discussion lengths were higher for larger values of absolute
average emotional valence in the first ten comments and the average amount of
emotion in messages fell during discussions. Our results prove that collective
emotional states can be created and modulated via Internet communication and
that emotional expressiveness is the fuel that sustains some e-communities.Comment: 23 pages including Supporting Information, accepted to PLoS ON
Ganciclovir/valganciclovir prophylaxis decreases cytomegalovirus-related events and bronchiolitis obliterans syndrome after lung transplantation
BACKGROUND: Until recently, cytomegalovirus (CMV) infection represented a major threat to lung transplant recipients. Preliminary studies have shown that antiviral prophylaxis might improve the outcome for these patients. METHODS: We extended our initial pilot trial of prolonged prophylaxis with either oral ganciclovir (1 g 3 times per day) or valganciclovir (450 mg twice per day). The trial included 96 patients who were at risk for CMV-related events. RESULTS: CMV prophylaxis resulted in a significant decrease in CMV-related events (i.e., active infection and disease), from 75% in a control group and for 274 cases from the literature who did not receive prophylaxis to a cumulative incidence of 27% (P < .001). Only 11% of the prophylaxis recipients experienced CMV disease (P = .002). Moreover, at 5 years, there was a significant decrease in the rate of bronchiolitis obliterans syndrome, from 60% to 43% (P = .002), and an improved rate of survival, from 47% to 73% (P= .036), irrespective of the immunosuppressive regimen received. CMV strains with UL97 mutations were recovered from 7 of 12 analyzed cases, but the presence of this mutation had no impact on the severity of CMV disease. CONCLUSIONS: A regimen of prolonged ganciclovir or valganciclovir prophylaxis decreased the rate of active CMV infection and disease, reduced the incidence of bronchiolitis obliterans syndrome, and improved the survival rate. Drug-resistant CMV strains may occur, but such strains appeared to have no impact on the outcome of CMV-related events
Correlation Structures of Correlated Binomial Models and Implied Default Distribution
We show how to analyze and interpret the correlation structures, the
conditional expectation values and correlation coefficients of exchangeable
Bernoulli random variables. We study implied default distributions for the
iTraxx-CJ tranches and some popular probabilistic models, including the
Gaussian copula model, Beta binomial distribution model and long-range Ising
model. We interpret the differences in their profiles in terms of the
correlation structures. The implied default distribution has singular
correlation structures, reflecting the credit market implications. We point out
two possible origins of the singular behavior.Comment: 16 pages, 7 figure
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Using a runway paradigm to assess the relative strength of rats' motivations for enrichment objects
Laboratory animals should be provided with enrichment objects in their cages; however, it is first necessary to
test whether the proposed enrichment objects provide benefits that increase the animals’ welfare. The two main
paradigms currently used to assess proposed enrichment objects are the choice test, which is limited to determining
relative frequency of choice, and consumer demand studies, which can indicate the strength of a preference but are complex to design. Here, we propose a third methodology: a runway paradigm, which can be used to assess the strength of an animal’s motivation for enrichment objects, is simpler to use than consumer demand studies, and is faster to complete than typical choice tests. Time spent with objects in a standard choice test was used to rank several enrichment objects in order to compare with the ranking found in our runway paradigm. The rats ran significantly more times, ran faster, and interacted longer with objects with which they had previously spent the most time. It was concluded that this simple methodology is suitable for measuring rats’ motivation to reach enrichment objects. This can be used to assess the preference for different types of enrichment objects or to measure reward system processes
CoCo trial: Color-coded blood pressure Control, a randomized controlled study
BACKGROUND: Inadequate blood pressure (BP) control is a frequent challenge in general practice. The objective of this study was to determine whether a color-coded BP booklet using a traffic light scheme (red, >180 mmHg systolic BP and/or >110 mmHg diastolic BP; yellow, >140–180 mmHg systolic BP or >90–110 mmHg diastolic BP; green, ≤140 mmHg systolic BP and ≤90 mmHg diastolic BP) improves BP control and adherence with home BP measurement. METHODS: In this two-group, randomized controlled trial, general practitioners recruited adult patients with a BP >140 mmHg systolic and/or >90 mmHg diastolic. Patients in the control group received a standard BP booklet and the intervention group used a color-coded booklet for daily home BP measurement. The main outcomes were changes in BP, BP control (treatment goal <140/90 mmHg), and adherence with home BP measurement after 6 months. RESULTS: One hundred and twenty-one of 137 included patients qualified for analysis. After 6 months, a significant decrease in systolic and diastolic BP was achieved in both groups, with no significant difference between the groups (16.1/7.9 mmHg in the intervention group versus 13.1/8.6 mmHg in the control group, P=0.3/0.7). BP control (treatment target <140/90 mmHg) was achieved significantly more often in the intervention group (43% versus 25%; P=0.037; number needed to treat of 5). Adherence with home BP measurement overall was high, with a trend in favor of the intervention group (98.6% versus 96.2%; P=0.1) CONCLUSION: Color-coded BP self-monitoring significantly improved BP control (number needed to treat of 5, meaning that every fifth patient utilizing color-coded self-monitoring achieved better BP control after 6 months), but no significant between-group difference was observed in BP change. A markedly higher percentage of patients achieved BP values in the normal range. This simple, inexpensive approach of color-coded BP self-monitoring is user-friendly and applicable in primary care, and should be implemented in the care of patients with arterial hypertension
Emotional persistence in online chatting communities
How do users behave in online chatrooms, where they instantaneously read and
write posts? We analyzed about 2.5 million posts covering various topics in
Internet relay channels, and found that user activity patterns follow known
power-law and stretched exponential distributions, indicating that online chat
activity is not different from other forms of communication. Analysing the
emotional expressions (positive, negative, neutral) of users, we revealed a
remarkable persistence both for individual users and channels. I.e. despite
their anonymity, users tend to follow social norms in repeated interactions in
online chats, which results in a specific emotional "tone" of the channels. We
provide an agent-based model of emotional interaction, which recovers
qualitatively both the activity patterns in chatrooms and the emotional
persistence of users and channels. While our assumptions about agent's
emotional expressions are rooted in psychology, the model allows to test
different hypothesis regarding their emotional impact in online communication.Comment: 34 pages, 4 main and 12 supplementary figure
Positivity of the English language
Over the last million years, human language has emerged and evolved as a
fundamental instrument of social communication and semiotic representation.
People use language in part to convey emotional information, leading to the
central and contingent questions: (1) What is the emotional spectrum of natural
language? and (2) Are natural languages neutrally, positively, or negatively
biased? Here, we report that the human-perceived positivity of over 10,000 of
the most frequently used English words exhibits a clear positive bias. More
deeply, we characterize and quantify distributions of word positivity for four
large and distinct corpora, demonstrating that their form is broadly invariant
with respect to frequency of word use.Comment: Manuscript: 9 pages, 3 tables, 5 figures; Supplementary Information:
12 pages, 3 tables, 8 figure
Observation of magnetic vortex pairs at room temperature in a planar {\alpha}-Fe2O3/Co heterostructure
Vortices are among the simplest topological structures, and occur whenever a
flow field `whirls' around a one-dimensional core. They are ubiquitous to many
branches of physics, from fluid dynamics to superconductivity and
superfluidity, and are even predicted by some unified theories of particle
interactions, where they might explain some of the largest-scale structures
seen in today's Universe. In the crystalline state, vortex formation is rare,
since it is generally hampered by long-range interactions: in ferroic materials
(ferromagnetic and ferroelectric), vortices are only observed when the effects
of the dipole-dipole interaction is modified by confinement at the nanoscale,
or when the parameter associated with the vorticity does not couple directly
with strain. Here, we present the discovery of a novel form of vortices in
antiferromagnetic (AFM) hematite (-FeO) epitaxial films, in
which the primary whirling parameter is the staggered magnetisation.
Remarkably, ferromagnetic (FM) topological objects with the same vorticity and
winding number of the -FeO vortices are imprinted onto an
ultra-thin Co ferromagnetic over-layer by interfacial exchange. Our data
suggest that the ferromagnetic vortices may be merons (half-skyrmions, carrying
an out-of-plane core magnetisation), and indicate that the vortex/meron pairs
can be manipulated by the application of an in-plane magnetic field,
H, giving rise to large-scale vortex-antivortex annihilation.Comment: 16 pages, 4 figure
Wetting films on chemically heterogeneous substrates
Based on a microscopic density functional theory we investigate the
morphology of thin liquidlike wetting films adsorbed on substrates endowed with
well-defined chemical heterogeneities. As paradigmatic cases we focus on a
single chemical step and on a single stripe. In view of applications in
microfluidics the accuracy of guiding liquids by chemical microchannels is
discussed. Finally we give a general prescription of how to investigate
theoretically the wetting properties of substrates with arbitrary chemical
structures.Comment: 56 pages, RevTeX, 20 Figure
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