Polyethylene glycol-coated collagen patch (hemopatch®) in open partial nephrectomy

PURPOSE To describe the results of a polyethylene glycol-coated collagen patch, Hemopatch® on blood loss, surgical time and renal function in partial nephrectomy (PN) for renal cell carcinoma (RCC). METHODS Out of a single surgeon cohort of n = 565 patients undergoing conventional open PN (CPN) between 01/2015 and 12/2017 at the University of Munich a consecutive subgroup (n = 42) was operated on using a polyethylene glycol-coated collagen-based sealant Hemopatch® (Baxter International Inc., Deerfield, IL, USA) (HPN). RESULTS Median age was 65.2~years (range 12.7-95.2) with median follow-up of 9.43~months (0.03-49.15). Baseline renal function (CKD-EPI) was 78.56~ml/min/1.73~m2 (range 20.38-143.09) with a non-significant decline to 74.78~ml/min/1.73~m2 (range 3.75-167.74) at follow-up. In CPN 46% had low complexity, 33% moderate complexity and 20% high complexity lesions with 33% low, 40% moderate and 27% high complexity masses in HPN. Median tumor size was 4.3~cm (range 1-38~cm) in CPN with 4.8~cm (range 3.8-18.3~cm) with HPN, p = 0.293. Median blood loss and duration of surgery was significantly lower in the HPN group vs. CPN (146~ml ± 195 vs. 114~ml ± 159~ml; p = 0.021; 43~min ± 27 for HPN vs. 53~min ± 49; p = 0.035) with no difference in clamping time (12.6~min ± 8.6 for HPN vs. 12.0~min ± 9.5; p = 0.701). CONCLUSIONS Hemopatch® supported renoraphy shows promising results compared to standard renoraphy in PN. No side effects were seen. Further studies should evaluate the prevention of arterio-venous or urinary fistulas. In complex partial nephrectomies Hemopatch® supported renoraphy should be considered

2-(3-Chloro-4-hydroxy­phen­yl)-N-(3,4-dimethoxy­pheneth­yl)acetamide

The title compound, C18H20ClNO4, was synthesized during the generation of a combinatorial library based on the fungal natural product 3-chloro-4-hydroxy­phenyl­acetamide. It crystallizes as discrete mol­ecules linked by inter­molecular C(9) chains of N—H⋯O and O—H⋯O hydrogen bonds which in turn combine to form chains of R 2 2(20) rings

N-Benzyl-2-(3-chloro-4-hy­droxy­phen­yl)acetamide

The title compound, C15H14ClNO2, was synthesized as part of a project to generate a combinatorial library based on the fungal natural product 2-(3-chloro-4-hy­droxy­phen­yl)acetamide. It crystallizes as non-planar discrete mol­ecules [the peripheral 3-chloro-4-hy­droxy­phenyl and benzyl groups are twisted out of the plane of the central acetamide group, with N—C—C—C and C—C—C—C torsion angles of −58.8 (3) and 65.0 (2)°, respectively] linked by inter­molecular N—H⋯O and O—H⋯O hydrogen bonds

Ethyl 6-r-(2-chlorophenyl)-2-oxo-4-phenyl­cyclohex-3-ene-1-t-carboxylate

In the title mol­ecule, C21H19ClO3, the cyclo­hexene ring adopts an envelope conformation, with all substituents equatorial. The plane through its five coplanar atoms makes dihedral angles of 12.75 (14) and 74.16 (8)° with the phenyl and benzene rings, respectively. The dihedral angle between the latter two rings is 81.73 (12)°. Inter­molecular C—H⋯O hydrogen bonds and intra­molecular C—H⋯Cl contacts are found in the crystal structure; a weak C—H⋯π inter­action is also present

N-(3-Chloro­propion­yl)-N′-phenyl­thio­urea

The title compound, C10H11ClN2OS, adopts a cis-trans configuration with respect to the position of the phenyl and 3-chloro­propionyl groups relative to the thiono group across the C—N bonds. The benzene ring is perpendicular to the propionyl thio­urea fragment with a dihedral angle of 82.62 (10)°. An intra­molecular N—H⋯O inter­action occurs. The crystal structure is stabilized by inter­molecular N—H⋯S hydrogen bonds, which link pairs of mol­ecules, building up R 2 2(8) ring motifs, and C—H.. π inter­actions

N-Butyl­pyridine-4-thio­carboxamide

In the title mol­ecule, C10H14N2S, the n-butyl chain assumes a trans zigzag conformation. The dihedral angle between the pyridine ring and the thio­amide plane is 23.38 (8)°. The mol­ecules in the crystal structure are linked by an inter­molecular N—H⋯N hydrogen bond

N′-[(E)-2-Hy­droxy-3,5-diiodo­benzyl­idene]cyclo­hexa­ne-1-carbohydrazide

In the title compound, C14H10I2N2O2, the two aromatic rings are inclined at a dihedral angle of 16.72 (33)°. The mol­ecular structure is stabilized by an intra­molecular O—H⋯N hydrogen bond. In the crystal, inter­molecular N—H⋯O inter­actions link the mol­ecules into chains running along the c axis. C—H⋯O inter­actions also occur. The crystal used for the structure determination was a non-merohedral twin with a domain ratio of 0.972 (2):0.028 (2)

(N 4-n-Butyl­pyridine-4-carbothio­amide-κN 4)chloridobis(dimethyl­glyoximato-κ2 N,N′)cobalt(III) hemihydrate

The title compound, trans-[Co(C4H7N2O2)2Cl(C10H14N2S)]·0.5H2O, contains two independent mol­ecules in the asymmetric unit in which the CoIII ions are coordinated in slightly distorted octa­hedral coordination environments. The bis-chelating glyoximate ligands, which occupy equatorial sites, are linked by interligand O—H⋯O hydrogen bonds. The dihedral angles between the mean planes of the glyoximate ligands in each mol­ecule are 2.07 (8) and 1.60 (1)°. The asymmetric unit contains a solvent water mol­ecule which is disordered over two sites with refined occupancies 0.64 (2) and 0.36 (2)

Dichlorido(dimethyl­glyoximato-κ2 N,N′)(dimethyl­glyoxime-κ2 N,N′)cobalt(III)

In the title compound, [Co(C4H7N2O2)Cl2(C4H8N2O2)], the CoIII ion has a distorted octa­hedral coordination environment. The equatorial plane consists of four N atoms, two each from the dimethyl­glyoxime and dimethyl­glyoximate ligands, while the two axial positions are occupied by two chloride ions. Strong intra­molecular O—H⋯O hydrogen bonds are observed between the dimethyl­glyoxime and dimethyl­glyoximate ligands. Mol­ecules are linked into a chain running along the [101] direction by O—H⋯O and C—H⋯Cl hydrogen bonds. The chains are cross-linked through inter­molecular C—H⋯Cl hydrogen bonds