2,589 research outputs found
Polyethylene glycol-coated collagen patch (hemopatch®) in open partial nephrectomy
PURPOSE To describe the results of a polyethylene glycol-coated collagen patch, Hemopatch® on blood loss, surgical time and renal function in partial nephrectomy (PN) for renal cell carcinoma (RCC). METHODS Out of a single surgeon cohort of n = 565 patients undergoing conventional open PN (CPN) between 01/2015 and 12/2017 at the University of Munich a consecutive subgroup (n = 42) was operated on using a polyethylene glycol-coated collagen-based sealant Hemopatch® (Baxter International Inc., Deerfield, IL, USA) (HPN). RESULTS Median age was 65.2~years (range 12.7-95.2) with median follow-up of 9.43~months (0.03-49.15). Baseline renal function (CKD-EPI) was 78.56~ml/min/1.73~m2 (range 20.38-143.09) with a non-significant decline to 74.78~ml/min/1.73~m2 (range 3.75-167.74) at follow-up. In CPN 46% had low complexity, 33% moderate complexity and 20% high complexity lesions with 33% low, 40% moderate and 27% high complexity masses in HPN. Median tumor size was 4.3~cm (range 1-38~cm) in CPN with 4.8~cm (range 3.8-18.3~cm) with HPN, p = 0.293. Median blood loss and duration of surgery was significantly lower in the HPN group vs. CPN (146~ml ± 195 vs. 114~ml ± 159~ml; p = 0.021; 43~min ± 27 for HPN vs. 53~min ± 49; p = 0.035) with no difference in clamping time (12.6~min ± 8.6 for HPN vs. 12.0~min ± 9.5; p = 0.701). CONCLUSIONS Hemopatch® supported renoraphy shows promising results compared to standard renoraphy in PN. No side effects were seen. Further studies should evaluate the prevention of arterio-venous or urinary fistulas. In complex partial nephrectomies Hemopatch® supported renoraphy should be considered
2-(3-Chloro-4-hydroxyphenyl)-N-(3,4-dimethoxyphenethyl)acetamide
The title compound, C18H20ClNO4, was synthesized during the generation of a combinatorial library based on the fungal natural product 3-chloro-4-hydroxyphenylacetamide. It crystallizes as discrete molecules linked by intermolecular C(9) chains of N—H⋯O and O—H⋯O hydrogen bonds which in turn combine to form chains of R
2
2(20) rings
N-Benzyl-2-(3-chloro-4-hydroxyphenyl)acetamide
The title compound, C15H14ClNO2, was synthesized as part of a project to generate a combinatorial library based on the fungal natural product 2-(3-chloro-4-hydroxyphenyl)acetamide. It crystallizes as non-planar discrete molecules [the peripheral 3-chloro-4-hydroxyphenyl and benzyl groups are twisted out of the plane of the central acetamide group, with N—C—C—C and C—C—C—C torsion angles of −58.8 (3) and 65.0 (2)°, respectively] linked by intermolecular N—H⋯O and O—H⋯O hydrogen bonds
Ethyl 6-r-(2-chlorophenyl)-2-oxo-4-phenylcyclohex-3-ene-1-t-carboxylate
In the title molecule, C21H19ClO3, the cyclohexene ring adopts an envelope conformation, with all substituents equatorial. The plane through its five coplanar atoms makes dihedral angles of 12.75 (14) and 74.16 (8)° with the phenyl and benzene rings, respectively. The dihedral angle between the latter two rings is 81.73 (12)°. Intermolecular C—H⋯O hydrogen bonds and intramolecular C—H⋯Cl contacts are found in the crystal structure; a weak C—H⋯π interaction is also present
N-Butylpyridine-4-thiocarboxamide
In the title molecule, C10H14N2S, the n-butyl chain assumes a trans zigzag conformation. The dihedral angle between the pyridine ring and the thioamide plane is 23.38 (8)°. The molecules in the crystal structure are linked by an intermolecular N—H⋯N hydrogen bond
N-(3-Chloropropionyl)-N′-phenylthiourea
The title compound, C10H11ClN2OS, adopts a cis-trans configuration with respect to the position of the phenyl and 3-chloropropionyl groups relative to the thiono group across the C—N bonds. The benzene ring is perpendicular to the propionyl thiourea fragment with a dihedral angle of 82.62 (10)°. An intramolecular N—H⋯O interaction occurs. The crystal structure is stabilized by intermolecular N—H⋯S hydrogen bonds, which link pairs of molecules, building up R
2
2(8) ring motifs, and C—H.. π interactions
N′-[(E)-2-Hydroxy-3,5-diiodobenzylidene]cyclohexane-1-carbohydrazide
In the title compound, C14H10I2N2O2, the two aromatic rings are inclined at a dihedral angle of 16.72 (33)°. The molecular structure is stabilized by an intramolecular O—H⋯N hydrogen bond. In the crystal, intermolecular N—H⋯O interactions link the molecules into chains running along the c axis. C—H⋯O interactions also occur. The crystal used for the structure determination was a non-merohedral twin with a domain ratio of 0.972 (2):0.028 (2)
(N 4-n-Butylpyridine-4-carbothioamide-κN 4)chloridobis(dimethylglyoximato-κ2 N,N′)cobalt(III) hemihydrate
The title compound, trans-[Co(C4H7N2O2)2Cl(C10H14N2S)]·0.5H2O, contains two independent molecules in the asymmetric unit in which the CoIII ions are coordinated in slightly distorted octahedral coordination environments. The bis-chelating glyoximate ligands, which occupy equatorial sites, are linked by interligand O—H⋯O hydrogen bonds. The dihedral angles between the mean planes of the glyoximate ligands in each molecule are 2.07 (8) and 1.60 (1)°. The asymmetric unit contains a solvent water molecule which is disordered over two sites with refined occupancies 0.64 (2) and 0.36 (2)
Dichlorido(dimethylglyoximato-κ2 N,N′)(dimethylglyoxime-κ2 N,N′)cobalt(III)
In the title compound, [Co(C4H7N2O2)Cl2(C4H8N2O2)], the CoIII ion has a distorted octahedral coordination environment. The equatorial plane consists of four N atoms, two each from the dimethylglyoxime and dimethylglyoximate ligands, while the two axial positions are occupied by two chloride ions. Strong intramolecular O—H⋯O hydrogen bonds are observed between the dimethylglyoxime and dimethylglyoximate ligands. Molecules are linked into a chain running along the [101] direction by O—H⋯O and C—H⋯Cl hydrogen bonds. The chains are cross-linked through intermolecular C—H⋯Cl hydrogen bonds
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