11,533 research outputs found
Number of adaptive steps to a local fitness peak
We consider a population of genotype sequences evolving on a rugged fitness
landscape with many local fitness peaks. The population walks uphill until it
encounters a local fitness maximum. We find that the statistical properties of
the walk length depend on whether the underlying fitness distribution has a
finite mean. If the mean is finite, all the walk length cumulants grow with the
sequence length but approach a constant otherwise. Experimental implications of
our analytical results are also discussed
Heat transfer to a gas containing a cloud of particles
Heat transfer to gas containing particle clou
The relationship between Hippocampal asymmetry and working memory processing in combat-related PTSD: a monozygotic twin study
BACKGROUND: PTSD is associated with reduction in hippocampal volume and abnormalities in hippocampal function. Hippocampal asymmetry has received less attention, but potentially could indicate lateralised differences in vulnerability to trauma. The P300 event-related potential component reflects the immediate processing of significant environmental stimuli and has generators in several brain regions including the hippocampus. P300 amplitude is generally reduced in people with PTSD. METHODS: Our study examined hippocampal volume asymmetry and the relationship between hippocampal asymmetry and P300 amplitude in male monozygotic twins discordant for Vietnam combat exposure. Lateralised hippocampal volume and P300 data were obtained from 70 male participants, of whom 12 had PTSD. We were able to compare (1) combat veterans with current PTSD; (2) their non-combat-exposed co-twins; (3) combat veterans without current PTSD and (4) their non-combat-exposed co-twins. RESULTS: There were no significant differences between groups in hippocampal asymmetry. There were no group differences in performance of an auditory oddball target detection task or in P300 amplitude. There was a significant positive correlation between P300 amplitude and the magnitude of hippocampal asymmetry in participants with PTSD. CONCLUSIONS: These findings suggest that greater hippocampal asymmetry in PTSD is associated with a need to allocate more attentional resources when processing significant environmental stimuli.Timothy Hall, Cherrie Galletly, C.R. Clark, Melinda Veltmeyer, Linda J. Metzger, Mark W. Gilbertson, Scott P. Orr, Roger K. Pitman and Alexander McFarlan
Age-Related Decrease in the Schaffer Collateral-Evoked EPSP in Awake, Freely, Behaving Rats
Synaptic response size in the CA1 region of
the hippocampus in aged rats is reduced for a
given stimulus intensity, compared with that
elicited in young rats. Consistent with the in vitro
findings of reduced Schaffer collateral-evoked
CA1 EPSPs in old rats, the population currents
evoked to iontophoretically applied AMPA are
also smaller relative to the presynaptic fiber
potential amplitude. On the other hand, the size of
the presynaptic fiber potential and amplitude of
unitary intra-cellularly recorded EPSP responses
do not change across age in the CA1 region. These
electrophysiological findings are consistent with
the hypothesis that old rats have fewer functional
synaptic contacts per Schaffer collateral axon
than do young rats. The possibility that this age
change arises as a result of a differential tissue
recovery response to in vitro preparation was
examined in the present study. CA1 presynaptic
fiber potential and EPSP amplitudes evoked by
the stimulation of Schaffer collateral afferents
were studied in intact, freely behaving young
and old rats. We confirmed in vivo the pattern of electrophysiophysiological results previously
reported in vitro and found significant
correlations between the synaptic response
amplitudes and the accuracy of spatial behavior
in the Morris swim task. The data suggest that
changes in functional connectivity of old rats
may be a significant contributor to cognitive
changes during aging
The Tropical Grassland Society of Australia Incorporated
The Tropical Grassland Society of Australia was formed in 1962 and became incorporated in 1987 and has the following aims: To publicise information of interest to primary producers and scientists To improve the relevance of research and adoption of technology through the flow of ideas between scientists and producers To publicise the findings of Australian pasture research and development to overseas workers, and to draw on their experience for application in Australi
The swan song: the disappearance of the nucleus of NGC 4051 and the echo of its past glory
BeppoSAX observed the low-luminous Seyfert 1 Galaxy NGC4051 in a ultra-dim
X-ray state. The 2-10 keV flux (1.26 x 10^{-12} erg/cm^2/s) was about 20 times
fainter than its historical average value, and remained steady along the whole
observation (~2.3 days). The observed flat spectrum (\Gamma ~ 0.8) and intense
iron line (EW ~600 eV) are best explained assuming that the active nucleus has
switched off, leaving only a residual reflection component visible.Comment: 5 pages, Latex, 3 Postscript figures, accepted for publication in
MNRA
Linear stability, transient energy growth and the role of viscosity stratification in compressible plane Couette flow
Linear stability and the non-modal transient energy growth in compressible
plane Couette flow are investigated for two prototype mean flows: (a) the {\it
uniform shear} flow with constant viscosity, and (b) the {\it non-uniform
shear} flow with {\it stratified} viscosity. Both mean flows are linearly
unstable for a range of supersonic Mach numbers (). For a given , the
critical Reynolds number () is significantly smaller for the uniform shear
flow than its non-uniform shear counterpart. An analysis of perturbation energy
reveals that the instability is primarily caused by an excess transfer of
energy from mean-flow to perturbations. It is shown that the energy-transfer
from mean-flow occurs close to the moving top-wall for ``mode I'' instability,
whereas it occurs in the bulk of the flow domain for ``mode II''. For the
non-modal analysis, it is shown that the maximum amplification of perturbation
energy, , is significantly larger for the uniform shear case compared
to its non-uniform counterpart. For , the linear stability operator
can be partitioned into , and the
-dependent operator is shown to have a negligibly small
contribution to perturbation energy which is responsible for the validity of
the well-known quadratic-scaling law in uniform shear flow: . A reduced inviscid model has been shown to capture all salient
features of transient energy growth of full viscous problem. For both modal and
non-modal instability, it is shown that the {\it viscosity-stratification} of
the underlying mean flow would lead to a delayed transition in compressible
Couette flow
Top Quark Physics at the Tevatron
The discovery of the top quark in 1995, by the CDF and D0 collaborations at
the Fermilab Tevatron, marked the dawn of a new era in particle physics. Since
then, enormous efforts have been made to study the properties of this
remarkable particle, especially its mass and production cross section. In this
article, we review the status of top quark physics as studied by the two
collaborations using the p-pbar collider data at sqrt(s) = 1.8 TeV. The
combined measurement of the top quark mass, m_t = 173.8 +- 5.0 GeV/c^2, makes
it known to a fractional precision better than any other quark mass. The
production cross sections are measured as sigma (t-tbar) = 7.6 -1.5 +1.8 pb by
CDF and sigma (t-tbar) = 5.5 +- 1.8 pb by D0. Further investigations of t-tbar
decays and future prospects are briefly discussed.Comment: 119 pages, 59 figures, 17 tables Submitted to Int. J. Mod. Phys. A
Fixed some minor error
Towards improved socio-economic assessments of ocean acidification’s impacts
Ocean acidification is increasingly recognized as a component of global change that could have a wide range of impacts on marine organisms, the ecosystems they live in, and the goods and services they provide humankind. Assessment of these potential socio-economic impacts requires integrated efforts between biologists, chemists, oceanographers, economists and social scientists. But because ocean acidification is a new research area, significant knowledge gaps are preventing economists from estimating its welfare impacts. For instance, economic data on the impact of ocean acidification on significant markets such as fisheries, aquaculture and tourism are very limited (if not non-existent), and non-market valuation studies on this topic are not yet available. Our paper summarizes the current understanding of future OA impacts and sets out what further information is required for economists to assess socio-economic impacts of ocean acidification. Our aim is to provide clear directions for multidisciplinary collaborative research
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