Drug utilization pattern in type II diabetes mellitus patients attending non-communicable disease clinic in a tertiary care hospital

Background: Diabetes mellitus is a metabolic disorder. Early institution of treatment is necessary to prevent complications. Since treatment of diabetes requires lifetime therapy; this study is designed to understand the prescription trends at Non Communicable Disease clinic set up and to provide rationale.Methods: This cross-sectional, observational study was conducted over a period of 2 months (May 2017- June 2017). Details of demographic data, duration and family history of diabetes, antidiabetic medications prescribed, history of comorbid diseases and drugs prescribed by physician for the treatment of comorbid diseases were collected in a structured format. Height and weight were recorded, and body mass index was calculated.Results: Study population included 294 patients and patients in the age groups of 40-59 years formed the bulk. 39% patients were overweight and 19.39% were obese. 93.20% patients were prescribed with metformin. 37 patients received insulin injection. 64.29% received more than one antidiabetic drug. Hypertension (82.05%) was the most common comorbid disease. Amlodipine was the most commonly prescribed antihypertensive drug.Conclusions: Metformin was the most commonly prescribed antidiabetic drug. Utilization of newer antidiabetic drug is inferior. Use of rationale fixed dose combination improves patient compliance

Surgical and functional outcome of management of anterior column with posterior hemitransverse fracture of acetabulum

Fractures of acetabulum are relatively uncommon, but as they involve the major weight bearing joint in lower extremity, they assume great clinical importance. The displaced acetabular fracture fragments result in hip joint incongruity which in turn leads to abnormal pressure distribution over the articular cartilage surface. This may lead to accelerated breakdown of the articular cartilage, resulting in disabling irreversible arthritis of hip joint. The aim of treatment of these difficult acetabular fractures is concentric reduction of femur head under the weight bearing dome of acetabulum resulting in anatomic reduction and followed by a stable fixation. This can be achieved only by adequately exposing the acetabulum and by rigid internal fixation. In our series 20 patients were included. Majority of the patients were males with mean age of 43.85±16.88 years. Most common mechanism of injury was road traffic accident. Right side was most affected. Most of the cases were isolated injuries. Majority of the cases had no complications. At the final follow up, most of the cases had Excellent follow-up according to Modified Merle d’Aubigne and Postel score. Surgical management of Anterior column with posterior hemitransverse fracture of acetabulum gives excellent outcomes with least number of complications

Neutron scattering study of magnetic phase separation in nanocrystalline La5/8_{5/8}Ca3/8_{3/8}MnO3_3

We demonstrate that magnetic phase separation and competing spin order in the colossal magnetoresistive (CMR) manganites can be directly explored via tuning strain in bulk samples of nanocrystalline La$_{1-x}$Ca$_x$MnO$_3$. Our results show that strain can be reversibly frozen into the lattice in order to stabilize coexisting antiferromagnetic domains within the nominally ferromagnetic metallic state of La$_{5/8}$Ca$_{3/8}$MnO$_3$. The measurement of tunable phase separation via magnetic neutron powder diffraction presents a direct route of exploring the correlated spin properties of phase separated charge/magnetic order in highly strained CMR materials and opens a potential avenue for realizing intergrain spin tunnel junction networks with enhanced CMR behavior in a chemically homogeneous material.Comment: 6 pages, 4 figures. New figure and text added to manuscrip

Magnetic order and the electronic ground state in the pyrochlore iridate Nd2Ir2O7

We report a combined muon spin relaxation/rotation, bulk magnetization, neutron scattering, and transport study of the electronic properties of the pyrochlore iridate Nd2Ir2O7. We observe the onset of strongly hysteretic behavior in the temperature dependent magnetization below 120 K, and an abrupt increase in the temperature dependent resistivity below 8 K. Zero field muon spin relaxation measurements show that the hysteretic magnetization is driven by a transition to a magnetically disordered state, and that below 8 K a complex magnetically ordered ground state sets in, as evidenced by the onset of heavily damped spontaneous muon precession. Our measurements point toward the absence of a true metal-to-insulator phase transition in this material and suggest that Nd2Ir2O7 lies either within or on the metallic side of the boundary of the Dirac semimetal regime within its topological phase diagram.Comment: 21 pages, 7 figure

Proposal to stabilize and detect half-quantum vortices in strontium ruthenate thin films: Non-Abelian braiding statistics of vortex matter in a px+ipy{p_x}+i{p_y} superconductor

We propose a simple way to stabilize half-quantum vortices in superconducting strontium ruthenate, assuming the order parameter is of chiral $p_x + ip_y$ symmetry, as is suggested by recent experiments. The method, first given by Salomaa and Volovik in the context of Helium-3, is very naturally suited for strontium ruthenate, which has a layered, quasi-two-dimensional, perovskite crystal structure. We propose possible experiments to detect their non abelian-braiding statistics. These experiments are of potential importance for topological quantum computation

Quasiparticle transport and localization in high-T_c superconductors

We present a theory of the effects of impurity scattering in d_{x^2-y^2} superconductors and their quantum disordered counterparts, based on a non-linear sigma model formulation. We show the existence, in a quasi-two-dimensional system, of a novel spin-metal phase with a non-zero spin diffusion constant at zero temperature. With decreasing inter-layer coupling, the system undergoes a quantum phase transition (in a new universality class) to a localized spin-insulator. Experimental implications for spin and thermal transport in the high-temperature superconductors are discussed.Comment: 4 pages, 1 figur

O(4)-Invariant Formulation of the Nodal Liquid

We consider the O(4) symmetric point in the phase diagram of an electron system in which there is a transition between d_{x^2 - y^2} density-wave order and d_{x^2 - y^2} superconductivity. If the pseudospin $SU(2)\subset O(4)$ symmetry is disordered by quantum fluctuations, the Nodal Liquid can result. In this context, we (1) construct a pseudospin $\sigma$-model; (2) discuss its topological excitations; (3) point out the possibility of a {\it pseudospin-Peierls} state and (4) propose a phase diagram for the underdoped cuprate superconductors

Dying To Find Out: The Cost of Time at the Dawn of the Multicancer Early Detection Era

Cancer is a significant burden worldwide that adversely impacts life expectancy, quality of life, health care costs, and workforce productivity. Although currently recommended screening tests for individual cancers reduce mortality, they detect only a minority of all cancers and sacrifice specificity for high sensitivity, resulting in a high cumulative rate of false positives. Blood-based multicancer early detection tests (MCED) based on next-generation sequencing (NGS) and other technologies hold promise for broadening the number of cancer types detected in screened populations and hope for reducing cancer mortality. The promise of this new technology to improve cancer detection rates and make screening more efficient at the population level demands the development of novel trial designs that accelerate clinical adoption. Carefully designed clinical trials are needed to address these issues