Genetic Basis of Myocarditis: Myth or Reality?

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Marine heatwaves in global sea surface temperature records since 1850

The adverse impacts of marine heatwaves (MHWs) on marine ecosystems and human activities are well-documented, yet observational studies tend to largely rely on recent records. Long-term records of MHWs can put the recent increase in frequency and intensity of MHWs in the context of past variability. We used long-term monthly sea surface temperature (SST) data and night marine air temperatures to characterise past MHW activity. A persistent increase in the global extent of MHWs is demonstrated, beginning around 1970. The average annual MHW extent post-2010 is estimated to be increased at least four fold compared to that pre-1970. A strong correlation between spatial variance of recorded average monthly SSTs and the average inverse number of monthly observations implies both frequency and amplitude of MHWs is overestimated when the number of monthly observations is low. Nevertheless, many identified early MHWs appear genuine, such as a multi-month event in the North Atlantic in 1851–1852. MHWs are also affected by poorer sampling during the world wars. The most extensive MHW years globally coincide with El Niño years, and MHW extent in the North Atlantic is correlated with the Atlantic Multidecadal Oscillation

Human 6-sulfo LacNAc-expressing dendritic cells are principal producers of early interleukin-12 and are controlled by erythrocytes.

Early and high-level production of IL-12 is crucial for effective immune responses against pathogens. Up until now, the cells providing this initial IL-12 have remained elusive. Here we show that a subset of human blood dendritic cells (DC) is the principal and primary source of IL-12p70 when blood leukocytes are stimulated with the TLR4-ligand LPS or with CD40-ligand. These so-called slanDC are characterized by the 6-sulfo LacNAc modification of PSGL-1, which is identified by the mAb M-DC8. The IL-12 response of slanDC requires a few hours of in vitro maturation, which is completely blocked in the presence of erythrocytes. This inhibition of maturation depends on the expression of CD47 on erythrocytes and of its ligand SIRPalpha on DC. While strictly controlled in the blood by erythrocytes, the high IL-12- and TNF-alpha-producing capacity of slanDC in tissues may be critical in fighting off pathogens; if uncontrolled, it may lead to adverse inflammatory reactions