Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists.

International audienceThe synthesis of new C-6 1,2,3-triazole adenosine derivatives via microwave assisted 1,3-dipolar cycloaddition as key step is described. The binding on membranes of cells that over express A(1) adenosine receptors (A(1)AR) was also evaluated. Among them, four compounds increased cAMP production, in a dose-dependent manner acting as antagonists of the A(1)AR, while two compounds act as agonists

Methodologie d'emploi de solutions salines saturees pour l'etalonnage d'hygrometres

Note interne *INRA Bioclimatologie STEFCE Montfavet (FRA) Diffusion du document : INRA Bioclimatologie STEFCE Montfavet (FRA)National audienc

Contrôle des hygromètres à impédance capacitive

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Design, Synthesis and Biological evaluation of a bivalent μ opiate and adenosine A1 receptors antagonist

International audienceWe designed and synthesized a new hetero-bivalent ligand having antagonist properties on both A1 adenosine and μ opiate receptors with a Ki of 0.8±0.05 and 0.7±0.03 μM, respectively. This bipolar compound increases cAMP production both in cells over expressing the μ receptor and in those over expressing the A1 adenosine receptor and reverses the antalgic effects of μ and A1 adenosine receptors agonist in animals

Design, Synthesis and Biological evaluation of a bivalent µ opiate and adenosine A1 receptor antagonist

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