Effects of Heat as a Taphonomic Agent on Kerf Dimensions

The information that can be derived from the rate of preservation of cremated human remains is highly valuable for forensic anthropologists and bioarchaeologists. Especially when taphonomic agents, such as fire, are intentionally introduced to obscure lesions on the skeleton. When sharp force trauma is present on bones, one of the main questions that arise is whether it is possible to tell what instrument was used for trauma infliction. This study used quantitative methods to examine kerfs on bones treated with heat as a taphonomic agent. The experiment used three sharp-bladed weapons to inflict trauma on porcine long bones: a single bladed non-serrated kitchen knife, a hacksaw, and a wood saw. The traumatised bones along with control bones were burnt in controlled laboratory conditions at temperatures ranging from 300°C to 1000°C. Quantitative analysis was undertaken on scanning electron microscopy images. Shrinkage of the kerf dimensions were recorded only at 1000°C; excepting marks from the wood saw, which instead showed an increase in maximum width. Individualisation of the saws was not possible using only the metric traits. However, the class of the weapons (knife versus saw) could always be identified. It has been concluded that burning may cause fluctuation in kerf width

MRI signal phase oscillates with neuronal activity in cerebral cortex: implications for neuronal current imaging

Neuronal activity produces transient ionic currents that may be detectable using magnetic resonance imaging (MRI). We examined the feasibility of MRI-based detection of neuronal currents using computer simulations based on the laminar cortex model (LCM). Instead of simulating the activity of single neurons, we decomposed neuronal activity to action potentials (AP) and postsynaptic potentials (PSP). The geometries of dendrites and axons were generated dynamically to account for diverse neuronal morphologies. Magnetic fields associated with APs and PSPs were calculated during spontaneous and stimulated cortical activity, from which the neuronal current induced MRI signal was determined. We found that the MRI signal magnitude change (< 0.1 ppm) is below currently detectable levels but that the signal phase change is likely to be detectable. Furthermore, neuronal MRI signals are sensitive to temporal and spatial variations in neuronal activity but independent of the intensity of neuronal activation. Synchronised neuronal activity produces large phase changes (in the order of 0.1 mrad). However, signal phase oscillates with neuronal activity. Consequently, MRI scans need to be synchronised with neuronal oscillations to maximise the likelihood of detecting signal phase changes due to neuronal currents. These findings inform the design of MRI experiments to detect neuronal currents

Fractional order magnetic resonance fingerprinting in the human cerebral cortex

Mathematical models are becoming increasingly important in magnetic resonance imaging (MRI), as they provide a mechanistic approach for making a link between tissue microstructure and signals acquired using the medical imaging instrument. The Bloch equations, which describes spin and relaxation in a magnetic field, is a set of integer order differential equations with a solution exhibiting mono-exponential behaviour in time. Parameters of the model may be estimated using a non-linear solver, or by creating a dictionary of model parameters from which MRI signals are simulated and then matched with experiment. We have previously shown the potential efficacy of a magnetic resonance fingerprinting (MRF) approach, i.e. dictionary matching based on the classical Bloch equations, for parcellating the human cerebral cortex. However, this classical model is unable to describe in full the mm-scale MRI signal generated based on an heterogenous and complex tissue micro-environment. The time-fractional order Bloch equations has been shown to provide, as a function of time, a good fit of brain MRI signals. We replaced the integer order Bloch equations with the previously reported time-fractional counterpart within the MRF framework and performed experiments to parcellate human gray matter, which is cortical brain tissue with different cyto-architecture at different spatial locations. Our findings suggest that the time-fractional order parameters, {\alpha} and {\beta}, potentially associate with the effect of interareal architectonic variability, hypothetically leading to more accurate cortical parcellation

Label-free detection of anticancer drug paclitaxel in living cells by confocal Raman microscopy

Confocal Raman microscopy, a non-invasive, label-free, and high spatial resolution imaging technique is employed to trace the anticancer drug paclitaxel in living Michigan Cancer Foundation-7 (MCF-7) cells. The Raman images were treated by K-mean cluster analysis to detect the drug in cells. Distribution of paclitaxel in cells is verified by calculating the correlation coefficient between the reference spectrum of the drug and the whole Raman image spectra. A time dependent gradual diffusion of paclitaxel all over the cell is observed suggesting a complementary picture of the pharmaceutical action of this drug based on rapid binding of free tubulin to crystallized paclitaxel. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4794871

Holographic Aspects of Fermi Liquids in a Background Magnetic Field

We study the effects of an external magnetic field on the properties of the quasiparticle spectrum of the class of 2+1 dimensional strongly coupled theories holographically dual to charged AdS$_4$ black holes at zero temperature. We uncover several interesting features. At certain values of the magnetic field, there are multiple quasiparticle peaks representing a novel level structure of the associated Fermi surfaces. Furthermore, increasing magnetic field deforms the dispersion characteristics of the quasiparticle peaks from non-Landau toward Landau behaviour. At a certain value of the magnetic field, just at the onset of Landau-like behaviour of the Fermi liquid, the quasiparticles and Fermi surface disappear.Comment: 18 pages, 10 figures. Revised some of the terminology: changed non-separable solutions to infinite-sum solution

Deconstructing holographic liquids

We argue that there exist simple effective field theories describing the long-distance dynamics of holographic liquids. The degrees of freedom responsible for the transport of charge and energy-momentum are Goldstone modes. These modes are coupled to a strongly coupled infrared sector through emergent gauge and gravitational fields. The IR degrees of freedom are described holographically by the near-horizon part of the metric, while the Goldstone bosons are described by a field-theoretical Lagrangian. In the cases where the holographic dual involves a black hole, this picture allows for a direct connection between the holographic prescription where currents live on the boundary, and the membrane paradigm where currents live on the horizon. The zero-temperature sound mode in the D3-D7 system is also re-analyzed and re-interpreted within this formalism.Comment: 21 pages, 2 figure

Non-relativistic metrics from back-reacting fermions

It has recently been pointed out that under certain circumstances the back-reaction of charged, massive Dirac fermions causes important modifications to AdS_2 spacetimes arising as the near horizon geometry of extremal black holes. In a WKB approximation, the modified geometry becomes a non-relativistic Lifshitz spacetime. In three dimensions, it is known that integrating out charged, massive fermions gives rise to gravitational and Maxwell Chern-Simons terms. We show that Schrodinger (warped AdS_3) spacetimes exist as solutions to a gravitational and Maxwell Chern-Simons theory with a cosmological constant. Motivated by this, we look for warped AdS_3 or Schrodinger metrics as exact solutions to a fully back-reacted theory containing Dirac fermions in three and four dimensions. We work out the dynamical exponent in terms of the fermion mass and generalize this result to arbitrary dimensions.Comment: 26 pages, v2: typos corrected, references added, minor change

Landau Levels, Magnetic Fields and Holographic Fermi Liquids

We further consider a probe fermion in a dyonic black hole background in anti-de Sitter spacetime, at zero temperature, comparing and contrasting two distinct classes of solution that have previously appeared in the literature. Each class has members labeled by an integer n, corresponding to the n-th Landau level for the fermion. Our interest is the study of the spectral function of the fermion, interpreting poles in it as indicative of quasiparticles associated with the edge of a Fermi surface in the holographically dual strongly coupled theory in a background magnetic field H at finite chemical potential. Using both analytical and numerical methods, we explicitly show how one class of solutions naturally leads to an infinite family of quasiparticle peaks, signaling the presence of a Fermi surface for each level n. We present some of the properties of these peaks, which fall into a well behaved pattern at large n, extracting the scaling of Fermi energy with n and H, as well as the dispersion of the quasiparticles.Comment: 23 pages, 4 figures. Changed some of the terminology: non-separable -> infinite-sum. Clarified the relationship between our ansatz and the separable ansat

A conical deficit in the AdS4/CFT3 correspondence

Inspired by the AdS/CFT correspondence we propose a new duality that allow the study of strongly coupled field theories living in a 2+1 conical space-time. Solving the 4-d Einstein equations in the presence of an infinite static string and negative cosmological constant we obtain a conical AdS4 space-time whose boundary is identified with the 2+1 cone found by Deser, Jackiw and 't Hooft. Using the AdS4/CFT3 correspondence we calculate retarded Green's functions of scalar operators living in the cone.Comment: v3, 14 pages. We reinterpret our results for the Green's functions in the con