Network Analysis with the Enron Email Corpus

We use the Enron email corpus to study relationships in a network by applying six different measures of centrality. Our results came out of an in-semester undergraduate research seminar. The Enron corpus is well suited to statistical analyses at all levels of undergraduate education. Through this note's focus on centrality, students can explore the dependence of statistical models on initial assumptions and the interplay between centrality measures and hierarchical ranking, and they can use completed studies as springboards for future research. The Enron corpus also presents opportunities for research into many other areas of analysis, including social networks, clustering, and natural language processing.Comment: in Journal of Statistics Education, Volume 23, Number 2, 201

Systemic Risk: Simulating Local Shocks To A Global System

Using our updated model of the payment exchange system within the banking industry, we have introduced sudden local economic shocks and calculated their effect on the stability of the financial system. Our results suggest that the probability of a total banking failure, i.e., the systemic risk of the system, is insignificant unless the degree of the shock and the degree of integration between banks are very large. We find that the larger the shock, i.e., the greater the amount of loss amongst all banks, and the more isolated banks are within the payment system, the greater the likelihood of a localized or global banking system failure. However, given the current limits percentages of capitol banks can loan each other, only worldwide economic crises of cataclysmic significance would cause a collapse of the entire banking system. Hence we affirm the findings of our previous work which considered the effects of a bank failure generated by factors internal to the banking system (internal instead of internal shocks), which suggest there is minimal systemic risk in an integrated, minimally regulated, banking system.

Finding the Missing Links among Metabolites, Microbes, and the Host

The unexpected diversity of the human microbiome and metabolome far exceeds the complexity of the human genome. Although we now understand microbial taxonomic and genetic repertoires in some populations, we are just beginning to assemble the necessary computational and experimental tools to understand the metabolome in comparable detail. However, even with the limited current state of knowledge, individual connections between microbes and metabolites, between microbes and immune function, and between metabolites and immune function are being established. Here, we provide our perspective on these connections and outline a systematic research program that could turn these individual links into a broader network that allows us to understand how these components interact. This program will enable us to exploit connections among the microbiome, metabolome, and host immune system to maintain health and perhaps help us understand how to reverse the processes that lead to a wide range of immune and other diseases

Ionization efficiency for nuclear recoils in silicon from ∼50\sim 50 eV to 33 MeV

We present a model for the nuclear recoil ionization efficiency in silicon based on an extension of Lindhard's theory where atomic bond disruption is modeled as a function of the initial ion energy, the interatomic potential, and the average ion-vacancy production energy. A better description of the electronic stopping than the one assumed by Lindhard, the effect of electronic straggling, as well as charge screening and Coulomb repulsion effects of ions are also considered. The model describes the available data over nearly four orders of magnitude in nuclear recoil energy.Comment: 5 pages, 3 figure

French translation and validation of the Jefferson Scale of Empathy - Health Professions Student version

Background: Background: Jefferson Scale of Empathy is one of the most widely used tools worldwide to assess empathy. The extended version for Health Professions Students (JSE HPS) has not yet been translated into French. Objective: The aim of our study was to translate the JSE HPS into French and assess the psychometric properties of this new version (JSE HPS Fr). Methods: The JSE HPS was translated according to international recommendations. The main psychometric qualities (test-retest reliability, internal consistency, floor and ceiling effects and construct validity) were studied in a sample of physiotherapy students. Participants provided general information (age, gender, year of study) and completed the JSE HPS Fr and the Questionnaire of Cognitive and Affective Empathy (QCAE). Participants were also asked to complete the JSE-HPS-Fr again one week later to assess its test-retest reliability. Results: 408 students (161 males and 247 females; mean age: 21.3 years) participated. The JSE HPS Fr demonstrated good test-retest reliability for the total score (ICC=0.81) and good internal consistency (α Cronbach: 0.79). The JSE HPS also showed good convergent validity with the QCAE questionnaire (r=0.41, p<0.05). No floor or ceiling effects were observed. Conclusions: The results indicate that the JSE HPS Fr is a valid and reliable tool to assess the level of empathy of French-speaking physiotherapy students

Systemic Risk : Simulating Local Shocks To A Global System

Using our updated model of the payment exchange system within the banking industry, we have introduced sudden local economic shocks and calculated their effect on the stability of the financial system. Our results suggest that the probability of a total banking failure, i.e., the systemic risk of the system, is insignificant unless the degree of the shock and the degree of integration between banks are very large. We find that the larger the shock, i.e., the greater the amount of loss amongst all banks, and the more isolated banks are within the payment system, the greater the likelihood of a localized or global banking system failure. However, given the current limits percentages of capitol banks can loan each other, only worldwide economic crises of cataclysmic significance would cause a collapse of the entire banking system. Hence we affirm the findings of our previous work which considered the effects of a bank failure generated by factors internal to the banking system (internal instead of internal shocks), which suggest there is minimal systemic risk in an integrated, minimally regulated, banking system

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

Parkinson’s disease is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates. Evidence suggests that α-Syn aggregation can originate in peripheral tissues and progress to the brain via autonomic fibers. We tested this by inoculating the duodenal wall of mice with α-Syn preformed fibrils. Following inoculation, we observed gastrointestinal deficits and physiological changes to the enteric nervous system. Using the AAV-PHP.S capsid to target the lysosomal enzyme glucocerebrosidase for peripheral gene transfer, we found that α-Syn pathology is reduced due to the increased expression of this protein. Lastly, inoculation of α-Syn fibrils in aged mice, but not younger mice, resulted in progression of α-Syn histopathology to the midbrain and subsequent motor defects. Our results characterize peripheral synucleinopathy in prodromal Parkinson’s disease and explore cellular mechanisms for the gut-to-brain progression of α-Syn pathology