A comparison of the load carrying characteristics of hydrostatic thrust bearing using monatomic, diatomic, and triatomic gases

The purpose of this investigation is to compare the load carrying characteristics of gases with different ratios of specific heat. The design, construction, and operation of an apparatus for testing and comparing the load carrying characteristics of gases are described. Several monatomic, diatomic, and triatomic gases were tested and the results evaluated and compared. The data are tabulated and displayed in a series of curves. It was found that the monatomic gases exhibit a greater clearance for a given load and a greater total load carrying capacity than the diatomic gases which in turn have a greater clearance and total load carrying capacity than the triatomic gases and that an increase in molecular weight decreases clearance and total load carrying capacity --Abstract, page ii

Young Man With Suspected Foreign Body Ingestion

As United States emergency departments (ED) and hospitals continue to contend with increasing numbers of patients presenting with complications of substance abuse, emergency physicians should also be aware of patients who may be smuggling illicit drugs. We report the case of a 26-year-old man who was transported to the ED for suspected drug smuggling. Abdominal computed tomography was notable for the presence of multiple tubular foreign bodies throughout the colon that were later identified as packets containing heroin. Body-packing patients present a high-risk clinical scenario that may result in massive, inadvertent drug exposure

The uncontrolled cooking test : measuring three-stone fire performance in northern Mozambique

The assessment of cooking system performance in developing countries is a continued area of interest, with laboratory testing methods often being unrepresentative of real world use, and field based methods tending to be resource intensive with high levels of variability. This paper presents the Uncontrolled Cook Test (UCT), a relatively low cost field testing protocol that assesses the task-based performance of the system when cooking any meal and operated as per local conditions and practice. A total of 29 UCTs were conducted in households in a study village in rural northern Mozambique, all on wood-burning three stone fires. The UCT proved a capable method for the assessment of cooking system performance and, critically, returned a data set with less variation than is typically reported by existing field test methods, so offering the potential to use fewer resources to detect a statistically significant difference between baseline and ‘improved’ stove results

Optimising the imbaula stove

In South Africa, human and environmental health implications from domestic solid fuel combustion have spurred interest in cleaner alternative sources of energy and better combustion technologies. Field research among wood and coal burning informal settlements in Johannesburg has shown that the most prevalent mode of combustion is self-made imbaula (brazier) stoves, manufactured from discarded 20 L steel drums. Such stoves are made without any measure of performance optimisation, leading to fuel inefficiency and high emissions - previous field surveys have indicated that the number, size and placement of primary and secondary air inlets (taken as holes below and above the fire grate respectively) vary over a wide range, starting from an extreme with no holes below the grate [1]. Researchers at SeTAR Centre, University of Johannesburg, have set out to develop an enhanced imbaula, by investigating performance in terms of size and distribution of primary and secondary air inlets, and height of grate level. The test imbaulas are constructed out of standard 20 L drums with a height of 360 mm and diameter of 295 mm. A range of hole configurations has been designed, from which selected test configurations are fabricated for experimental evaluation of thermal and emissions properties, using the SeTAR heterogeneous testing protocol. The results indicate that higher hole densities (above and below the grate) lead to higher power outputs and lower specific CO emissions, but with lower thermal efficiency. Further, results indicate that adequate air holes below the grate (primary air) are more important for proper combustion in an imbaula; however this should be synchronised with secondary air in-lets (above the grid) in order to have congruence of all the performance criteria. This study should lead to the development of a set of criteria that can further enhance emissions reductions and fuel efficiency obtained by top-down stove ignition methods (Basa njengo Magogo) for imbaula type stoves

For cook and climate: Certify cookstoves in their contexts of use

Improved cookstoves are widely promoted as a health and climate improving technology, yet there remains a wide gap between their reputed benefits and the inconclusive outcomes of most interventions. An increasing number of scientists suggest that the popular lab protocols used to test, rate and model the benefits of improved cookstoves are at least partly to blame. Insights from a recent study of improved cookstove users in Darfur, Sudan, reveal the extent to which the logic and goals of lab-based testing protocols differ from actual cooking practices. We elaborate on the climate and energy policy implications of decontextualized lab tests and conclude with a call to design, test and select for dissemination only those improved cookstoves that are rated on the basis of their intended contexts of use

1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis.

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease with no known cure. Current strategies to treat RA, including methotrexate (MTX), target the later inflammatory stage of disease. Recently, we showed that inhibiting indoleamine-2,3-dioxygenase (IDO) with 1-methyl-tryptophan (1MT) targets autoantibodies and cytokines that drive the initiation of the autoimmune response. Therefore, we hypothesized that combining 1MT with MTX would target both the initiation and chronic inflammatory phases of the autoimmune response and be an effective co-therapeutic strategy for arthritis. To test this, we used K/BxN mice, a pre-clinical model of arthritis that develops joint-specific inflammation with many characteristics of human RA. Mice were treated with 1MT, MTX, alone or in combination, and followed for arthritis, autoantibodies, and inflammatory cytokines. Both 1MT and MTX were able to partially inhibit arthritis when used individually; however, combining MTX + 1MT was significantly more effective than either treatment alone at delaying the onset and alleviating the severity of joint inflammation. We went on to show that combination of MTX + 1MT did not lower inflammatory cytokine or autoantibody levels, nor could the synergistic co-therapeutic effect be reversed by the adenosine receptor antagonist theophylline or be mimicked by inhibition of polyamine synthesis. However, supplementation with folinic acid did reverse the synergistic co-therapeutic effect, demonstrating that, in the K/BxN model, MTX synergizes with 1MT by blocking folate metabolism. These data suggest that pharmacological inhibition of IDO with 1MT is a potential candidate for use in combination with MTX to increase its efficacy in the treatment of RA

A scoping review of burden of disease studies estimating disability-adjusted life years due to Taenia solium

Background Taenia solium is the most significant global foodborne parasite and the leading cause of preventable human epilepsy in low and middle-income countries in the form of neurocysticercosis. Objectives This scoping review aimed to examine the methodology of peer-reviewed studies that estimate the burden of T. solium using disability-adjusted life years. Eligibility criteria Studies must have calculated disability-adjusted life years relating to T. solium. Charting methods The review process was managed by a single reviewer using Rayyan. Published data relating to disease models, data sources, disability-adjusted life years, sensitivity, uncertainty, missing data, and key limitations were collected. Results 15 studies were included for review, with seven global and eight national or sub-national estimates. Studies primarily employed attributional disease models that relied on measuring the occurrence of epilepsy before applying an attributable fraction to estimate the occurrence of neurocysticercosis-associated epilepsy. This method relies heavily on the extrapolation of observational studies across populations and time periods; however, it is currently required due to the difficulties in diagnosing neurocysticercosis. Studies discussed that a lack of data was a key limitation and their results likely underestimate the true burden of T. solium. Methods to calculate disability-adjusted life years varied across studies with differences in approaches to time discounting, age weighting, years of life lost, and years of life lived with disability. Such differences limit the ability to compare estimates between studies. Conclusions This review illustrates the complexities associated with T. solium burden of disease studies and highlights the potential need for a burden of disease reporting framework. The burden of T. solium is likely underestimated due to the challenges in diagnosing neurocysticercosis and a lack of available data. Advancement in diagnostics, further observational studies, and new approaches to parameterising disease models are required if estimates are to improve

A conceptual framework for evaluating cooking systems

PUBLISHED 7 March 2022Tami C Bond, Christian L, Orange, Paul R Medwell, George Sizoomu, Samer Abdelnour, Verena Brinkmann, Philip Lloyd and Crispin Pemberton-Pigot

Intraoperative radiotherapy for breast cancer

Intra-operative radiotherapy (IORT) as a treatment for breast cancer is a relatively new technique that is designed to be a replacement for whole breast external beam radiotherapy (EBRT) in selected women suitable for breast-conserving therapy. This article reviews twelve reasons for the use of the technique, with a particular emphasis on targeted intra-operative radiotherapy (TARGIT) which uses X-rays generated from a portable device within the operating theatre immediately after the breast tumour (and surrounding margin of healthy tissue) has been removed. The delivery of a single fraction of radiotherapy directly to the tumour bed at the time of surgery, with the capability of adding EBRT at a later date if required (risk-adaptive technique) is discussed in light of recent results from a large multinational randomised controlled trial comparing TARGIT with EBRT. The technique avoids irradiation of normal tissues such as skin, heart, lungs, ribs and spine, and has been shown to improve cosmetic outcome when compared with EBRT. Beneficial aspects to both institutional and societal economics are discussed, together with evidence demonstrating excellent patient satisfaction and quality of life. There is a discussion of the published evidence regarding the use of IORT twice in the same breast (for new primary cancers) and in patients who would never be considered for EBRT because of their special circumstances (such as the frail, the elderly, or those with collagen vascular disease). Finally, there is a discussion of the role of the TARGIT Academy in developing and sustaining high standards in the use of the technique

Illusions and Delusions: Relating Experimentally-Induced False Memories to Anomalous Experiences and Ideas

The salience hypothesis of psychosis rests on a simple but profound observation that subtle alterations in the way that we perceive and experience stimuli have important consequences for how important these stimuli become for us, how much they draw our attention, how they embed themselves in our memory and, ultimately, how they shape our beliefs. We put forward the idea that a classical memory illusion – the Deese–Roediger–McDermott (DRM) effect – offers a useful way of exploring processes related to such aberrant belief formation. The illusion occurs when, as a consequence of its relationship to previous stimuli, a stimulus that has not previously been presented is falsely remembered. Such illusory familiarity is thought to be generated by the surprising fluency with which the stimulus is processed. In this respect, the illusion relates directly to the salience hypothesis and may share common cognitive underpinnings with aberrations of perception and attribution that are found in psychosis. In this paper, we explore the theoretical importance of this experimentally-induced illusion in relation to the salience model of psychosis. We present data showing that, in healthy volunteers, the illusion relates directly to self reported anomalies of experience and magical thinking. We discuss this finding in terms of the salience hypothesis and of a broader Bayesian framework of perception and cognition which emphasizes the salience both of predictable and unpredictable experiences