The effect of preoperative 5-fluorouracil on colonic healing: An experimental study

WOS: 000172705600026PubMed ID: 11813589Background/Aims: After curative resection for colorectal carcinoma there is a high recurrence rate and neoadjuvant chemotherapy may be useful in some patients. Very little is known about the effect of preoperative 5-fluorouracil on the healing of colon anastomosis. The aim of this study was to evaluate the effect of 5-fluorouracil on colonic healing when the time interval between the last injection and operation was shortened to 24 hours. Methodology: Thirty-six male Wistar rats with a median weight of 185g (range: 165-200g) were divided into three groups: 1) control group (n=12); 2) sham group (n=12) which received saline intraperitoneally, and 3) study group (n=12) which received 5-fluorouracil intraperitoneally (20mg/kg(-1)). All injections were given intraperitoneally for 5 days and the last dose was injected 24 hours before operation. Results: The mortality rate (22.7%) and anastomotic complications (29.4%) were increased in the 5-fluorouracil group, compared with the control or saline groups (P <0.05). The anastomotic bursting pressure in rats having 5-fluorouracil treatment (27mm Hg) was significantly lower from both the control (55mm Hg) and saline (84mm Hg) groups on postoperative day 3 (P <0.05). Both myeloperoxidase and hydroxyproline contents were also significantly lower than the other groups (P <0.05). Conclusions: Colonic healing was impaired and mortality rate was increased when intraperitoneal 5-fluorouracil treatment was repeated until 24 hours before operation

Apilarnil reduces fear and advances sexual development in male broilers but has no effect on growth

WOS: 000320864100011PubMed ID: 237961181. An experiment was conducted to determine the possibility of stimulating sexual development at an early age in male and female broiler chickens by administration of apilarnil, a natural bee product, in the pre-pubertal period. 2. From 28 to 55 d of age, birds were given apilarnil orally. The effects of low (2.5 g/bird) and high (7.5 g/bird) doses of apilarnil on growth performance, testicular weight, secondary sexual characteristics, blood lipids, testosterone and fearful behaviour were evaluated. 3. Apilarnil administration did not cause a positive effect on growth performance of male and female broilers suggesting that apilarnil did not have an anabolic effect. 4. Apilarnil administration suppressed blood glucose and cholesterol. 5. Birds receiving apilarnil remained immobile for a shorter period in a tonic imobiliy test and showed less home-cage avoidance responses suggesting a lower level of fearfulness. 6. Increases in testicular weight, testosterone concentration and comb growth in males receiving apilarnil implied that it stimulates the sexual maturation at an early age. However, a similar stimulation of secondary sexual characteristics was not observed in females.Scientific Research Projects Committee at Ege UniversityEge University [2003-ZRF-024]This study was funded by the Scientific Research Projects Committee at Ege University Project number (2003-ZRF-024). We wish to thank Ozlem Agricultural Product A.S. for providing broiler chickens and Keskinoglu Group for supplying feed materials