Solar Neutron Events of October-November 2003

During the period when the Sun was intensely active on October-November 2003, two remarkable solar neutron events were observed by the ground-based neutron monitors. On October 28, 2003, in association with an X17.2 large flare, solar neutrons were detected with high statistical significance (6.4 sigma) by the neutron monitor at Tsumeb, Namibia. On November 4, 2003, in association with an X28 class flare, relativistic solar neutrons were observed by the neutron monitors at Haleakala in Hawaii and Mexico City, and by the solar neutron telescope at Mauna Kea in Hawaii simultaneously. Clear excesses were observed at the same time by these detectors, with the significance calculated as 7.5 sigma for Haleakala, and 5.2 sigma for Mexico City. The detector onboard the INTEGRAL satellite observed a high flux of hard X-rays and gamma-rays at the same time in these events. By using the time profiles of the gamma-ray lines, we can explain the time profile of the neutron monitor. It appears that neutrons were produced at the same time as the gamma-ray emission.Comment: 35 pages, 21 figures, accepted for publication in Ap

—How Much Should You Invest in Each Customer Relationship? A Competitive Strategic Approach

We analyze firms' decisions to invest in customer relationship management (CRM) initiatives such as acquisition and retention in a competitive context, a topic largely ignored in past CRM research. We characterize each customer by her intrinsic preference towards each firm, the contribution margin she generates for each firm, and her responsiveness to each firm's retention and acquisition efforts. We show that a firm should invest most heavily in retaining those customers that exhibit moderate responsiveness to its CRM efforts. Further, a firm should most aggressively seek to attract those customers that exhibit moderate responsiveness to their provider's CRM efforts and those that are moderately profitable for their current provider. Investing more in customers that are more responsive does not always lead to higher firm profits, because stronger competition for such customers tends to erode the effects of higher CRM efforts of an individual firm. When firms develop a customer relationship over time to generate higher contribution margin or customer responsiveness, we show that such developments may not always be desirable, because sometimes these future benefits may lead to more intense competition and hence lower profits for both firms.customer relationship management, competitive strategy, game theory, customer lifetime value, customer equity, customer acquisition, customer development, customer retention, services marketing, relationship marketing

Rotavirus increases levels of lipidated LC3 supporting accumulation of infectious progeny virus without inducing autophagosome formation

Replication of many RNA viruses benefits from subversion of the autophagic pathway through many different mechanisms. Rotavirus, the main etiologic agent of pediatric gastroenteritis worldwide, has been recently described to induce accumulation of autophagosomes as a mean for targeting viral proteins to the sites of viral replication. Here we show that the viral-induced increase of the lipidated form of LC3 does not correlate with an augmented formation of autophagosomes, as detected by immunofluorescence and electron microscopy. The LC3-II accumulation was found to be dependent on active rotavirus replication through the use of antigenically intact inactivated viral particles and of siRNAs targeting viral genes that are essential for viral replication. Silencing expression of LC3 or of Atg7, a protein involved in LC3 lipidation, resulted in a significant impairment of viral titers, indicating that these elements of the autophagic pathway are required at late stages of the viral cycle