Magnetization of densely packed interacting magnetic nanoparticles with cubic and uniaxial anisotropies: A Monte Carlo study

International audienceThe magnetization curves of densely packed single domain magnetic nanoparticles (MNP) are investigated by Monte Carlo simulations in the framework of an effective one spin model. The particles whose size polydispersity is taken into account are arranged in spherical clusters and both dipole dipole interactions (DDI) and magnetic anisotropy energy (MAE) are included in the total energy. Having in mind the special case of spinel ferrites of intrinsic cubic symmetry, combined cubic and uniaxial magnetocrystalline anisotropies are considered with different configurations for the orientations of the cubic and uniaxial axes. It is found that the DDI, together with a marked reduction of the linear susceptibility are responsible for a damping of the peculiarities due to the MAE cubic component on the magnetization. As an application, we show that the simulated magnetization curves compare well to experimental results for $\gamma$--Fe$_2$O$_3$ MNP for small to moderate values of the field

An innovative nanoprobe for magnetic immunoassay: Individual gamma-Fe2O3 nanoparticles; towards high sensitive and multiparametric detection

1 - ArticleA new type of nanolabels for magnetic immunoassays was designed using individual superparamagnetic gamma-Fe2O3 nanoparticles. This innovative candidate is confronted here with commonly used micrometric beads. The innovative MIAplex (R) technology allows to characterize and to quantify both types of labels with a competitive limit of detection. In this paper, we demonstrate the feasibility of multiparametric immunotests with the MIAplex (R) technology. The carboxylic functions at the outer particle surface act as a precursor group for the covalent coupling of biological recognition molecules, such as antibodies, nucleic acids. (C) 2011 Elsevier Masson SAS. All rights reserved

SiO2 versus chelating agent@ iron oxide nanoparticles: interactions effect in nanoparticles assemblies at low magnetic field

International audienceHydrophilic magnetic nanoparticles present many interest for various medical applications due to their unique properties: immunoassays, imaging and hyperthermia. With regards to their applicability in the biomedical field, colloidal stability is a key parameter related to nanoparticle surface functionalization. In this paper, we report the water transfer of hydrophobic oleic acid coated iron oxide nanoparticles comparing two methodologies to obtain water dispersible iron oxide nanoparticles: exchange ligands with small strong chelating agent (caffeic acid) and SiO2 shell passivation. Both strategies are leading to stable aqueous ferrofluid but differing by their interactions. The non linear magnetic behavior at high and low magnetic field and second derivative signature of water dispersed superparamagnetic Fe304 nanoparticles samples are studied using conventional SQUID equipment and miniaturized detector MIAplex® device. We demonstrated those samples differing only by their interparticle interactions present different magnetic behavior at very low magnetic field whereas at high magnetic field both samples are very similar

SiO2 versus chelating agent@ iron oxide nanoparticles: interactions effect in nanoparticles assemblies at low magnetic field

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Carbodiimide versus Click Chemistry for Nanoparticle Surface Functionalization: A Comparative Study for the Elaboration of Multimodal Superparamagnetic Nanoparticles Targeting αvβ3 Integrins.

International audienceSuperparamagnetic fluorescent nanoparticles targeting αvβ3 integrins were elaborated using two methodologies: carbodiimide coupling and click chemistries (CuACC and thiol-yne). The nanoparticles are first functionalized with hydroxymethylenebisphonates (HMBP) bearing carboxylic acid or alkyne functions. Then, a large number of these reactives functions were used for the covalent coupling of dyes, poly(ethylene glycol) (PEG), and cyclic RGD. Several methods were used to characterize the nanoparticle surface functionalization, and the magnetic properties of these contrast agents were studied using a 1.5 T clinical MRI. The affinity toward integrins was evidenced by solid-phase receptor-binding assay. In addition to their chemoselective natures, click reactions were shown to be far more efficient than the carbodiimide coupling. The grafting increase was shown to enhance targeting affinity to integrin without imparing MRI and fluorescent properties