Clinical reliability of complete-arch fixed prostheses supported by narrow-diameter implants to support complete-arch restorations

The aim of this study was to evaluate the clinical application of fixed screw-retained complete-arch rehabilitations supported by four narrow-diameter implants (NDIs). The records of patients treated with complete-arch prostheses screwed onto four NDIs treated with an immediate loading protocol between 2010 and 2020 with at least 1 year of follow-up after the positioning of the definitive restoration were reviewed. The implants were placed according to the final prosthetic design and were immediately loaded. The interim prostheses were replaced after the healing period by definitive acrylic resin titanium-supported prostheses. Patients were followed to evaluate treatment success, the implant survival rate (ISR), and the prosthetic survival rate (PSR). A total of 121 NDIs were positioned in 30 patients to restore 30 complete arches (18 maxilla and 12 mandible). One implant did not achieve osseointegration, resulting in an overall ISR of 99.2%. No prosthetic or implant failures occurred during the 1 to 11 years of follow-up. Three biological and four prosthetic complications occurred, resulting in a treatment rehabilitation survival of 94.1% and a PSR of 86.7%. Despite the limitations of the present retrospective study, such as the use of one single type of dental implant and patients treated in a single rehabilitation center, complete-arch rehabilitation with fixed prostheses supported by four NDIs seems to be a reliable treatment in the medium to long term

Clinical Reliability of Complete-Arch Fixed Prostheses Supported by Narrow-Diameter Implants to Support Complete-Arch Restorations

The aim of this study was to evaluate the clinical application of fixed screw-retained complete-arch rehabilitations supported by four narrow-diameter implants (NDIs). The records of patients treated with complete-arch prostheses screwed onto four NDIs treated with an immediate loading protocol between 2010 and 2020 with at least 1 year of follow-up after the positioning of the definitive restoration were reviewed. The implants were placed according to the final prosthetic design and were immediately loaded. The interim prostheses were replaced after the healing period by definitive acrylic resin titanium-supported prostheses. Patients were followed to evaluate treatment success, the implant survival rate (ISR), and the prosthetic survival rate (PSR). A total of 121 NDIs were positioned in 30 patients to restore 30 complete arches (18 maxilla and 12 mandible). One implant did not achieve osseointegration, resulting in an overall ISR of 99.2%. No prosthetic or implant failures occurred during the 1 to 11 years of follow-up. Three biological and four prosthetic complications occurred, resulting in a treatment rehabilitation survival of 94.1% and a PSR of 86.7%. Despite the limitations of the present retrospective study, such as the use of one single type of dental implant and patients treated in a single rehabilitation center, complete-arch rehabilitation with fixed prostheses supported by four NDIs seems to be a reliable treatment in the medium to long term

Depression of early phase of HTLV-I infection in vitro mediated by human beta-interferon.

Natural human interferon beta (beta-IFN) was tested during the early phase of in vitro infection with HTLV-I virus of human cord blood mononuclear cells (CBL), to evaluate whether its antiviral and immunomodulating effects might prevent spreading of infection in the host. beta-IFN was found to reduce HTLV-I transmission and integration in CBL cultures. Moreover, beta-IFN had no effect in preventing virus transmission and integration in K562 and a very limited effect in HL60 and Molt-4 human tumour lines, suggesting a cell-type specific mode of action. beta-IFN induced a 'priming' response on CBL, since overnight pretreatment of recipient cells or one single treatment at the onset of the coculture were almost equally effective in protecting against HTLV-I infection. During the early days post infection (p.i.), IFN-treated CBL showed a pattern of phenotypic markers that was closer to that of non-infected CBL. In contrast, untreated CBL exposed to HTLV-I showed a percent increase of Tac+, M3+ and Leu 11+ subpopulations. Cell-mediated immune responses of CBL were depressed after coculturing with HTLV-I producer MT-2 cells. beta-IFN was able to boost the cell-mediated cytotoxicity of fresh and infected CBL against both K562 and MT-2 target cells. Leukocyte blastogenesis in mixed lymphocyte/tumour cell cultures, evaluated in terms of 3H-thymidine incorporation during the first week p.i., was also enhanced by IFN when macrophages and lymphocytes were reconstituted at an optimal 1:20 ratio. It is conceivable that this overall enhancement of the immune response induced by beta-IFN could contribute to reduce HTLV-I infection in vitro

Hemispheric Asymmetry of Globus Pallidus Explains Reward-related Posterior Alpha Modulation in Humans

While subcortical structures such as the basal ganglia (BG) have been widely explored in relation to motor control, recent evidence suggests that their mechanisms extend to the domain of attentional switching. We here investigated the subcortical involvement in reward related top-down control of visual alpha-band oscillations (8 – 13 Hz), which have been consistently linked to the mechanisms supporting the allocation of visual spatial attention. Given that items associated with contextual saliency (e.g. monetary reward or loss) attract attention, it is not surprising that alpha oscillations are further modulated by the saliency properties of the visual items. The executive network controlling such reward-dependent modulations of oscillatory brain activity has yet to be fully elucidated. Although such network has been explored in terms of cortico-cortical interaction, it likely relies also on the contribution of subcortical regions. To uncover this, we investigated whether derived measures of subcortical structural asymmetries could predict interhemispheric modulation of alpha power during a spatial attention task. We show that volumetric hemispheric lateralization of globus pallidus (GP) and thalamus (Th) explains individual hemispheric biases in the ability to modulate posterior alpha power. Importantly, for the GP, this effect became stronger when the value-saliency parings in the task increased. Our findings suggest that the Th and GP in humans are part of a subcortical executive control network, differently involved in modulating posterior alpha activity. Further investigation aimed at uncovering the interaction between subcortical and neocortical attentional networks would provide useful insight in future studies

Dual stage resistive transition of MgB2 evidenced by noise analysis

The resistive transition of polycrystalline superconducting MgB2 films is studied by means of an extensive set of stationary noise measurements, going from the very beginning of the transition to its final point, where the normal state is reached, either with and without magnetic field. The experimental results, taken at low current density and close to the critical temperature Tc, show very clearly the existence of two different dissipative processes at the different stages of the transition. An extended analysis proves that, at the beginning of the transition, when the resistance is below ten percent of normal value, the specimen is in a mixed state and dissipation is produced by fluxoid creation and motion. At higher temperature the specimen is in an intermediate state, constituted by a structure of interleaved superconducting and resistive domains. Such a situation occurs in type II superconductor when the transition temperature is very near to Tc and the critical field Hc for fluxoid penetration tends to zero. It is found that in the intermediate state, the power spectrum of the relative resistance fluctuations, is independent of the average resistance value and is unaffected by the magnetic field. As shown in the paper, this means that the noise is generated by density fluctuation of the normal electron gas in the resistive domains, while the contribution of the superconducting ones is negligible. The reduced noise amplitude does not depend on the steepness of the transition curve, thus adding further evidence to the above interpretation. The noise is thus related to the film impurities and can be investigated when the specimen is in the normal state, even at room temperature. The occurrence of a different dissipative process at low resistance is clearly evidenced by the experimental results, which show that the amplitude of the reduced power spectrum of the noise depends on magnetic field and resistance. These results are consistent with the assumption of fluxoid noise as shown by the model for the calculation of the noise developed in the manuscrip

Influence of Xpand Nitric Oxide Reactor, L-Arginine Alpha-Ketoglutarate, and Caffeine Supplementation on Calf Muscle Re-Oxygenation During and after Acute Resistance Exercise

Xpand Nitric Oxide Reactor is a "cocktail" supplement proposed to improve skeletal muscle blood flow via arginine's effect on nitric oxide synthesis and vasodilation. Two other major ingredients, caffeine and creatine, cause vasoconstriction, which could potentially counteract the proposed hemodynamic effects of arginine. The purpose of this study was to examine the influence of Xpand Nitric Oxide Reactor on muscle re-oxygenation after resistance exercise compared to supplementation with constituent ingredients L-arginine alpha-ketoglutarate and caffeine. Nine recreationally active men (21±1y) performed 3 sets of 20 repetitions of seated single-leg calf raise at 60% 1-RM with 3 min rests. The same calf raise exercise was performed following 4 separate supplementation conditions: L-arginine alpha-ketoglutarate (AAKG), caffeine (CAFF), Xpand Nitric Oxide Reactor (XPAND), and placebo (PLAC). Soleus muscle re-oxygenation time was measured before, during, and immediately after exercise using near infrared spectroscopy. Supplementation with XPAND (0.43±0.03), AAKG (0.34±0.02), and CAFF (0.45±0.05) did not significantly affect muscle re-oxygenation halftime (minutes) compared to placebo (0.35±0.04). An arginine containing "cocktail" supplement did not affect skeletal muscle re-oxygenation after resistance exercise, possibly due to a wash-out effect caused by the multiple ingredients

Driving Rate Effects on Crackling Noise

Many systems respond to slowly changing external conditions with crackling noise, created by avalanches or pulses of a broad range of sizes. Examples range from Barkhausen Noise in magnets to earthquakes. Here we discuss how the scaling behavior of the avalanche size and duration distribution and the power spectra of this noise depend on the rate at which the external conditionsare changed. We derive an exponent inequality as a criteria for the relevance of adding a small driving rate to the adiabatic model. We use the zero temperature nonequilibrium random field Ising model to test our results, which are expected to be applicable to a large class of systems with crackling noise. They also agree with recent experiments on Barkhausen noise in various materials.Comment: 4 pages, 2 figures, REVTe

Lattice calculation of the DsD_{s} meson radiative form factors over the full kinematical range

We compute the structure-dependent axial and vector form factors for the radiative leptonic decays $D_s\to \ell\nu_\ell\gamma$, where $\ell$ is a charged lepton, as functions of the energy of the photon in the rest frame of the $D_s$ meson. The computation is performed using gauge-field configurations with 2+1+1 sea-quark flavours generated by the European Twisted Mass Collaboration and the results have been extrapolated to the continuum limit. For the vector form factor we observe a very significant partial cancellation between the contributions from the emission of the photon from the strange quark and that from the charm quark. The results for the form factors are used to test the reliability of various Anz\"atze based on single-pole dominance and its extensions, and we present a simple parametrization of the form factors which fits our data very well and which can be used in future phenomenological analyses. Using the form factors we compute the differential decay rate and the branching ratio for the process $D_s\to e\nu_e\gamma$ as a function of the lower cut-off on the photon energy. With a cut-off of 10 MeV for example, we find a branching ratio of Br$(E_\gamma>10\,\mathrm{MeV})=4.4(3)\times 10^{-6}$ which, unlike some model calculations, is consistent with the upper bound from the BESIII experiment Br$(E_\gamma>10\,\mathrm{MeV})<1.3\times 10^{-4}$ at 90% confidence level. Even for photon energies as low as 10 MeV, the decay $D_s\to e\nu_e\gamma$ is dominated by the structure-dependent contribution to the amplitude (unlike the decays with $\ell=\mu$ or $\tau$), confirming its value in searches for hypothetical new physics as well as in determining the Cabibbo-Kobayashi-Maskawa (CKM) parameters at $O(\alpha_\mathrm{em})$, where $\alpha_{\mathrm{em}}$ is the fine-structure constant.Comment: 31 pages, 14 figure