Balancing the formal and the informal in user-centred design

This paper explores the role of formal methods as part of the user-centred design of interactive systems. An iterative process is described, developing prototypes incrementally, proving user-centred requirements while at the same time evaluating the prototypes that are executable forms of the developed models using ‘traditional’ techniques for user evaluation. A formal analysis complements user evaluations. This approach enriches user-centred design that typically focuses understanding on context and producing sketch designs. These sketches are often non-functional (e.g. paper) prototypes. They provide a means of exploring candidate design possibilities using techniques such as cooperative evaluation. This paper describes a further step in the process using formal analysis techniques. The use of formal methods provides a systematic approach to checking plausibility and consistency during early design stages, while at the same time enabling the generation of executable prototypes. The technique is illustrated through an example based on a pill dispenser.This work is financed by National Funds through the Portuguese funding agency, FCT -- Fundação para a Ciência e a Tecnologia, within project UIDB/50014/2020

Verification templates for the analysis of user interface software design

The paper describes templates for model-based analysis of usability and safety aspects of user interface software design. The templates crystallize general usability principles commonly addressed in user-centred safety requirements, such as the ability to undo user actions, the visibility of operational modes, and the predictability of user interface behavior. These requirements have standard forms across different application domains, and can be instantiated as properties of specific devices. The modeling and analysis process is carried out using the Prototype Verification System (PVS), and is further facilitated by structuring the specification of the device using a format that is designed to be generic across interactive systems. A concrete case study based on a commercial infusion pump is used to illustrate the approach. A detailed presentation of the automated verification process using PVS shows how failed proof attempts provide precise information about problematic user interface software features.This work has been funded by the EPSRC research grant EP/G059063/1: CHI+ MED (Computer-Human Interaction for Medical Devices). We are grateful to Harold Thimbleby's team at Swansea University, part of the CHI+ MED project, and especially Patrick Oladimeji who developed the infusion pump simulation that helped us develop the models. We also thank the anonymous reviewers for valuable feedback. Jose C. Campos and Paolo Masci were funded by project NORTE-01-0145-FEDER-000016, financed by the North Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, and through the European Regional Development Fund (ERDF)

Electromagnetic field measurements in ULF-ELF-VLF [0.001 Hz─100 KHz] bands

We are reporting the technological and scientific objectives of the MEM project. The MEM project has been activated in the INGV Observatory of L'Aquila to create in Central Italy a network of observatories in order to monitoring the electromagnetic signals in the frequency band [0.001 Hz–100 kHz]. Some examples of the instrumentation developed in the frame of the project are reported. An innovative technique, based on the wide band interferometry is proposed to obtain detailed information concerning the several detected electromagnetic sources. Moreover, data from each station will be elaborated to investigate different sectors as the structure of ground electric conductibility, the electromagnetic phenomena connected with seismic activity, the separation of the electromagnetic fields originated in the Earth's interior and the electromagnetic phenomena originated in the magnetosphere, in the ionosphere and in the Earth-ionosphere cavity

Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities

Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new antiviral agents against dengue infection. In addition, there is no approved anti-DENV agents for treating DENV-infected patients. In the present study, we identified new compounds with anti-DENV replication activity by targeting viral replication enzymes – NS5, RNA-dependent RNA polymerase (RdRp) and NS3 protease, using cell-based reporter assay. Subsequently, we performed an enzyme-based assay to clarify the action of these compounds against DENV RdRp or NS3 protease activity. Moreover, these compounds exhibited anti-DENV activity in vivo in the ICR-suckling DENV-infected mouse model. Combination drug treatment exhibited a synergistic inhibition of DENV replication. These results describe novel prototypical small anti-DENV molecules for further development through compound modification and provide potential antivirals for treating DENV infection and DENV-related diseases

Layers, resources and property templates in the specification and analysis of two interactive systems

The paper briefly explores a layered approach to the analysis of two interactive systems (Nuclear Control and Air Traffic Control), indicating how the analysis enables exploration of the particular features emphasised by the use cases relating to the examples. These features relate to the interactive behaviour of the systems. To facilitate the analysis, property templates are proposed as heuristics for developing appropriate requirements for the respective user interfaces.Jose Creissac Campos and Michael Harrison were funded by ´ project ref. NORTE-07-0124-FEDER-000062, co-financed by the North Portugal Regional Operational Programme (ON.2 O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF), and by national funds, through the Portuguese foundation for science and technology (FCT). Paul Curzon, Michael Harrison and Paolo Masci were funded by the CHI+MED project: Multidisciplinary Computer Human Interaction Research for the design and safe use of interactive medical devices project, UK EPSRC Grant Number EP/G059063/1.info:eu-repo/semantics/publishedVersio

The development of the INGV tectonomagnetic network in the frame of the MEM Project

In the middle of 1989, the INGV (Italian <i>Istituto Nazionale di Geofisica e Vulcanologia</i>) installed in Central Italy a network of magnetic stations in order to investigate possible relationship of the local magnetic field with earthquakes occurrences. Actually the network consists of four stations, where the total magnetic field intensity data are being collected using proton precession magnetometers. Here we are report on the actual state and the future developments of the network. In the frame of the MEM (Magnetic and Electric fields Monitoring) Project, new stations will be added to the network by the end of 2007. The results of the test campaigns carried out in the sites chosen to widen the network are also discussed. Moreover, the 2006 complete data set of the network is also reported. Concerning the data analysis, a new approach is also discussed that takes into account the inductive effects on the local geomagnetic field by means of the inter-station transfer functions time variations analysis

The study of the electromagnetic anomalies linked with the Earth's crustal activity in the frequency band [0.001 Hz?100 kHz]

International audienceThe technological and the scientific objectives of the MEM (Magnetic and Electric fields Monitoring) project concerning to the study of the electromagnetic signals linked with the Earth's crustal activity are reported. The MEM project has been activated in Central Italy to create a network of observatories so as to monitoring the electromagnetic signals, both natural and artificial, in the frequency band [0.001 Hz?100 kHz]. Some examples of the developed instrumentation and the know-how transfer to the industry are reported. We also report some results obtained in the first MEM station installed in the area of the INGV (Italian Istituto Nazionale di Geofisica e Vulcanologia) Observatory of L'Aquila. Using the single station magnetotelluric approach we have obtained some valuables information about the underground resistivity structure in the area of the measurement station. Concerning to the study of the magnetic signals linked with the tectonic activity we have reported an example of the long term behaviour of the magnetic induction vectors characteristics in the lower frequency band [0.001?0.5] Hz, showing their normal behaviour when no large crustal changes due to geodynamical processes are present

Automated theorem proving for the systematic analysis of an infusion pump

This paper describes the use of an automated theorem prover to analyse properties of interactive behaviour. It offers an alternative to model checking for the analysis of interactive systems. There are situations, for example when demonstrating safety, in which alternative complementary analyses provide assurance to the regulator. The rigour and detail offered by theorem proving makes it possible to explore features of the design of the interactive system, as modelled, beyond those that would be revealed using model checking. Theorem proving can also speed up proof in some circumstances. The paper illustrates how a theory generated as a basis for theorem proving (using PVS) was developed systematically from a MAL model used to model check the same properties. It also shows how the CTL properties used to check the original model can be translated into theorems.CHI+MED, EPSRC research grant EP/G059063/