3,196 research outputs found

    Organs from animals for man

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    In the following review some of the problems of xenotransplantation shall be discussed, based on the few experimental data available so far and on reports in the literature describing investigations which may be of importance for xenotransplantation. The impact of gravity on the upright posture of man versus almost all other mammals, the dysfunction between enzymes and hormones in different species and the lack of interactions between interleukins, cytokines and vasoactive substances will be taken into consideration. The question must be asked whether different levels of carrier molecules or serum proteins play a role in the physiological network. Even though the development of transgenic animals or other imaginative manipulations may lead to the acceptance of any type of xenografted organ, it has to be established for how long the products of the xenografts are able to act in the multifactorial orchestra. We are far from understanding xenogeneic molecular mechanisms involved in toxicity, necrosis and apoptosis or even reperfusion injury and ischemia in addition to the immediate mechanisms of the hyperacute xenogeneic rejection. Here, cell adhesion, blood clotting and vasomotion collide and bring micro-and macrocirculation to a standstill. All types of xenogeneic immunological mechanisms studied so far were found to have a more serious impact than those seen in allogeneic transplantation. In addition we are now only beginning to understand that so-called immunological parameters in allogeneic mechanisms act also in a true physiological manner in the xenogeneic situation. These molecular mechanisms occur behind the curtain of hyperacute, accelerated, acute or chronic xenograft rejection of which only some folds have been lifted to allow glimpses of part of the total scene. Other obstacles are likely to arise when long-term survival is achieved. These obstacles include retroviral infections, transfer of prions and severe side effects of the massive immunosuppression which will be needed. Moral, ethical and religious concerns are under debate and the species-specific production of proteins of the foreign donor species developed for clinical use suddenly appears to be a greater problem than anticipated

    Injection locking of two frequency-doubled lasers with 3.2 GHz offset for driving Raman transitions with low photon scattering in 43^{43}Ca+^+

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    We describe the injection locking of two infrared (794 nm) laser diodes which are each part of a frequency-doubled laser system. An acousto-optic modulator (AOM) in the injection path gives an offset of 1.6 GHz between the lasers for driving Raman transitions between states in the hyperfine split (by 3.2 GHz) ground level of 43^{43}Ca+^+. The offset can be disabled for use in 40^{40}Ca+^+. We measure the relative linewidth of the frequency-doubled beams to be 42 mHz in an optical heterodyne measurement. The use of both injection locking and frequency doubling combines spectral purity with high optical power. Our scheme is applicable for providing Raman beams across other ion species and neutral atoms where coherent optical manipulation is required.Comment: 3 pages, 3 figure

    Optimizing Stimulation and Analysis Protocols for Neonatal fMRI

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    The development of brain function in young infants is poorly understood. The core challenge is that infants have a limited behavioral repertoire through which brain function can be expressed. Neuroimaging with fMRI has great potential as a way of characterizing typical development, and detecting abnormal development early. But, a number of methodological challenges must first be tackled to improve the robustness and sensitivity of neonatal fMRI. A critical one of these, addressed here, is that the hemodynamic response function (HRF) in pre-term and term neonates differs from that in adults, which has a number of implications for fMRI. We created a realistic model of noise in fMRI data, using resting-state fMRI data from infants and adults, and then conducted simulations to assess the effect of HRF of the power of different stimulation protocols and analysis assumptions (HRF modeling). We found that neonatal fMRI is most powerful if block-durations are kept at the lower range of those typically used in adults (full on/off cycle duration 25-30s). Furthermore, we show that it is important to use the age-appropriate HRF during analysis, as mismatches can lead to reduced power or even inverted signal. Where the appropriate HRF is not known (for example due to potential developmental delay), a flexible basis set performs well, and allows accurate post-hoc estimation of the HRF

    Diffusion Enhancement in a Periodic Potential under High-Frequency Space-Dependent Forcing

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    We study the long-time behavior of underdamped Brownian particle moving through a viscous medium and in a systematic potential, when it is subjected to a space-dependent high-frequency periodic force. When the frequency is very large, much larger than all other relevant system-frequencies, there is a Kapitsa time-window wherein the effect of frequency dependent forcing can be replaced by a static effective potential. Our new analysis includes the case when the forcing, in addition to being frequency-dependent, is space-dependent as well. The results of the Kapitsa analysis then lead to additional contributions to the effective potential. These are applied to the numerical calculation of the diffusion coefficient (D) for a Brownian particle moving in a periodic potential. Presented are numerical results, which are in excellent agreement with theoretical predictions and which indicate a significant enhancement of D due to the space-dependent forcing terms. In addition we study the transport property (current) of underdamped Brownian particles in a ratchet potential.Comment: RevTex 6 pages, 5 figure

    High-fidelity quantum logic gates using trapped-ion hyperfine qubits

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    We demonstrate laser-driven two-qubit and single-qubit logic gates with fidelities 99.9(1)% and 99.9934(3)% respectively, significantly above the approximately 99% minimum threshold level required for fault-tolerant quantum computation, using qubits stored in hyperfine ground states of calcium-43 ions held in a room-temperature trap. We study the speed/fidelity trade-off for the two-qubit gate, for gate times between 3.8μ\mus and 520μ\mus, and develop a theoretical error model which is consistent with the data and which allows us to identify the principal technical sources of infidelity.Comment: 1 trap, 2 ions, 3 nines. Detailed write-up of arXiv:1406.5473 including single-qubit gate data als
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