146 research outputs found
Amplitude Damping for single-qubit System with single-qubit mixed-state Environment
We study a generalized amplitude damping channel when environment is
initially in the single-qubit mixed state. Representing the affine
transformation of the generalized amplitude damping by a three-dimensional
volume, we plot explicitly the volume occupied by the channels simulatable by a
single-qubit mixed-state environment. As expected, this volume is embedded in
the total volume by the channels which is simulated by two-qubit enviroment.
The volume ratio is approximately 0.08 which is much smaller than 3/8, the
volume ratio for generalized depolarizing channels.Comment: 13 pages, 2 figures incluided V2: homepage address is included in
reference V3: version to appear in J. Phys. A: Mathematical and Theoretica
Phytochemical screening, cytotoxicity and acute toxicity of Annona vepretorum Mart (Annonaceae) leaf extracts
Purpose: To investigate the phytochemistry, cytotoxicity and acute toxicity of leaf extracts from Annona vepretorum.Methods: The crude extracts were obtained by maceration with hexane and methanol. The crude methanol extract was suspended in a 3:7 (v/v) mixture of methanol (MeOH) and water (H2O) and partitioned with hexane, chloroform (CHCl3) and ethyl acetate (AcOEt) in ascending order of polarity to obtain the respective extracts. In the investigation of phytochemical profile, the extracts were evaluated on thin layer chromatography (TLC) plates of silica gel. Cytotoxicity was tested using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) (MTS) assays against tumor cell lines, viz,HCT-116 (colon), SF-295 (brain), HL-60 (leukemic) and Sarcoma-180. Acute toxicity study was performed by administration of a single oral dose of 2 g/kg body weight of the extracts to mice and the animals were observed for 14 days.Results: Phytochemical screening results showed that A. vepretorum extracts contain alkaloids, flavonoids and terpenes. Methanol and chloroform extracts exhibited high cytotoxic activity against HCT-116, HL-60 and Sarcoma-180. Moreover, the extracts displayed low toxicity in mice, as no deaths and pronounced toxic effects were observed.Conclusion: A. vepretorum contains a variety of secondary metabolites which may confer on this species high cytotoxic activity. In addition, the oral administration of the extracts produced low toxicity in mice.Keywords: Annonaceae, Annona vepretorum, Phytochemistry, Tumor cell lines, Acute toxicit
An algorithm to enumerate all possible protein conformations verifying a set of distance constraints
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