A liver fibrosis cocktail? Psoriasis, methotrexate and genetic hemochromatosis

BACKGROUND: Pathologists are often faced with the dilemma of whether to recommend continuation of methotrexate therapy for psoriasis within the context of an existing pro-fibrogenic risk factor, in this instance, patients with genetic hemochromatosis. CASE PRESENTATIONS: We describe our experience with two male psoriatic patients (A and B) on long term methotrexate therapy (cumulative dose A = 1.56 gms and B = 7.88 gms) with hetero- (A) and homozygous (B) genetic hemochromatosis. These patients liver function were monitored with routine biochemical profiling; apart from mild perivenular fibrosis in one patient (B), significant liver fibrosis was not identified in either patient with multiple interval percutaneous liver biopsies; in the latter instance this patient (B) had an additional risk factor of partiality to alcohol. CONCLUSION: We conclude that methotrexate therapy is relatively safe in patients with genetic hemochromatosis, with no other risk factor, but caution that the risk of fibrosis be monitored, preferably by non-invasive techniques, or by liver biopsy

Immunogenicity and safety of measles-mumps-rubella-varicella (MMRV) vaccine followed by one dose of varicella vaccine in children aged 15 months–2 years or 2–6 years primed with measles-mumps-rubella (MMR) vaccine

The authors would like to thank all the investigators who participated in this clinical trial as well as study nurses and other staff members. They would also like to acknowledge the parents and children who participated in the study. We thank Jennifer Coward, who provided medical writing services, and Catherine Arnaudeau-Bégard for publication coordination. GlaxoSmithKline Biologicals took in charge all the costs associated with the development and the publishing of the present manuscript

Economics for the right to work

This article argues that mainstream economic theory is one of the main reasons why the human right to work, which was recognized by the international community in 1966, appears not to have been taken seriously. In the mainstream discourse, labour is a cost, employment is a second-tier objective, individuals are resources with production specifications, and rights are rigidities. Economics based on human rights and seeking to promote the right to work must construe that right as more than just fighting unemployment, regard full employment as an end in itself and place the individual at the heart of its raison d’être