Short Gas Dissipation Timescales: Diskless Stars in Taurus and Chamaeleon I

We present an Advanced Camera for Surveys/ Solar Blind Channel far-ultraviolet (FUV) study of \h2 gas in 12 weak T Tauri stars in nearby star-forming regions. The sample consists of sources which have no evidence of inner disk dust. Our new FUV spectra show that in addition to the dust, the gas is depleted from the inner disk. This sample is combined with a larger FUV sample of accretors and non-accretors with ages between 1 and 100 Myr, showing that as early as 1--3 Myr, systems both with and without gas are found. Possible mechanisms for depleting gas quickly include viscous evolution, planet formation and photoevaporation by stellar radiation fields. Since these mechanisms alone cannot account for the lack of gas at 1--3 Myr, it is likely that the initial conditions (e.g. initial disk mass or core angular momentum) contribute to the variety of disks observed at any age. We estimate the angular momentum of a cloud needed for most of the mass to fall very close to the central object and compare this to models of the expected distribution of angular momenta. Up to 20% of cloud cores have low enough angular momenta to form disks with the mass close to the star, which would then accrete quickly; this percentage is similar to the fraction of diskless stars in the youngest star forming regions. With our sample, we characterize the chromospheric contribution to the FUV luminosity and find that $L_{FUV}/L_{bol}$ saturates at $\sim10^{-4.1}$.Comment: 5 pages, 4 figures, Accepted to ApJ

Sexual dimorphism in the Drosophila melanogaster (Diptera: Drosophilidae) metabolome increases throughout development

The expression of sexually dimorphic phenotypes from a shared genome between males and females is a longstanding puzzle in evolutionary biology. Increasingly, research has made use of transcriptomic technology to examine the molecular basis of sexual dimorphism through gene expression studies, but even this level of detail misses the metabolic processes that ultimately link gene expression with the whole organism phenotype. We use metabolic profiling in Drosophila melanogaster to complete this missing step, with a view to examining variation in male and female metabolic profiles, or metabolomes, throughout development. We show that the metabolome varies considerably throughout larval, pupal and adult stages. We also find significant sexual dimorphism in the metabolome, although only in pupae and adults, and the extent of dimorphism increases throughout development. We compare this to transcriptomic data from the same population and find that the general pattern of increasing sex differences throughout development is mirrored in RNA expression. We discuss our results in terms of the usefulness of metabolic profiling in linking genotype and phenotype to more fully understand the basis of sexually dimorphic phenotypes

A feed-forward measurement scheme for periodic noise suppression in atomic magnetometry

We present an unshielded, double-resonance magnetometer in which we have implemented a feed-forward measurement scheme in order to suppress periodic magnetic noise arising from, and correlated with, the mains electricity alternating current line. The technique described here uses a single sensor to track ambient periodic noise and feed forward to suppress it in a subsequent measurement. This feed forward technique has shown significant noise suppression of electrical mains-noise features of up to 22 dB under the fundamental peak at 50 Hz, 3 dB at the first harmonic (100 Hz), and 21 dB at the second harmonic (150 Hz). This technique is software based, requires no additional hardware, and is easy to implement in an existing magnetometer

Detecting differential gene expression in blastocysts following pronuclear transfer.

Nuclear transfer techniques (a.k.a. mitochondrial replacement therapies) are currently under development to provide a route to eliminating particular instances of mitochondrial disease from the germline. Before these kinds of techniques are implemented clinically it is of primary concern that their safety and efficacy is established. In a recent paper, Hyslop et al. (Nature 534:383-386, 2016. doi: 10.1038/nature18303 ) utilized a specific version of pronuclear transfer to investigate the consequences for gene expression in the developing embryo, which may indicate whether or not developmental pathways have been perturbed. However, the study was only able to include a small number of blastocysts within each treatment group, although a larger number of single cell expression profiles from each blastocyst were acquired. Using simulated datasets we show that the size and experimental design of this study cannot provide conclusive evidence that expression profiles of manipulated or control samples are indistinguishable from one another due to low power. These simulations also illustrate why visual inspections of principle component analyses used in the study cannot replace statistical modeling of treatment effects

Optically pumped magnetometry in arbitrarily oriented magnetic fields

Optically pumped atomic magnetometers (OPMs) offer highly sensitive magnetic measurements using compact hardware, offering new possibilities for practical precision sensors. Double-resonance OPM operation is well suited to unshielded magnetometry, due to high sensor dynamic range. However, sensor response is highly anisotropic with variation in the orientation of the magnetic field. We present data quantifying these effects and discuss implications for the design of practical sensors

Ultra-low noise, bi-polar, programmable current sources

We present the design process and implementation of fully open-source, ultra-low noise programmable current source systems in two configurations. Although originally designed as coil drivers for Optically Pumped Magnetometers (OPMs), the device specifications make them potentially useful in a range of applications. The devices feature a bi-directional current range of $\pm$~10~mA and $\pm$~250~mA respectively on three independent channels with 16-bit resolution. Both devices feature narrow 1/f noise bandwidth of 1~Hz, enabling magnetic field manipulation for high-performance OPMs. They exhibit low noise of 146.3~pA/$\sqrt{\mathrm{Hz}}$ and 4114~pA/$\sqrt{\mathrm{Hz}}$ which translates to 14.57~ppb/$\sqrt{\mathrm{Hz}}$ and 16.46~ppb/$\sqrt{\mathrm{Hz}}$ noise relative to full scale.Comment: 9 pages, 9 figure