The importance of social connectedness for self-regulation and emotional wellbeing: Expanding the definition of the construct

At the time of writing, we remain in the midst of the Covid-19 pandemic. During this time, the enactment of social distancing policies needed to curb the spread of disease has also heightened attention to the emotional costs of isolation on psychosocial development and mental health. In this chapter, we examine the construct of social connectedness (the ability to relate to others) and discuss its association with emotional intelligence and regulation. We present data from a crosssectional survey of 133 undergraduate students, and a structural equation model in which social connectedness mediates the effect of the maternal relationship in childhood on alexithymia and experiential avoidance in young adulthood. A latent factor of social connectedness was extracted from measures of attachment security and feelings of understanding from others. The maternal relationship was assessed by retrospective ratings of maternal warmth, hostility, and neglect. Social connectedness was predicted by the maternal relationship (B = .31) and in turn, was predictive of alexithymia (B = -.82) and experiential avoidance (B = -.72). The ability to relate to others is highly associated with self regulation of emotions. Interventions to improve emotion management in young adults may also need to repair issues of social connectedness in this group

real world treatment outcomes in patients with metastatic merkel cell carcinoma treated with chemotherapy in the usa

Aim: This retrospective study of patients in the USA with metastatic Merkel cell carcinoma (mMCC) aimed to assess patient responses to second-line and later (2L+) and first-line (1L) chemotherapy. Patients & methods: Out of 686 patients with MCC identified in The US Oncology Network, 20 and 67 patients with mMCC qualified for the 2L+ and 1L study, respectively; the primary analysis population was restricted to immunocompetent patients. Results: In the 2L+ primary analysis population, objective response rate (ORR) was 28.6%, median duration of response (DOR) was 1.7 months and median progression-free survival was 2.2 months. In the 1L primary analysis population, ORR was 29.4%, median DOR was 6.7 months and median progression-free survival was 4.6 months. Conclusion: The low ORR and brief DOR underscore the need for novel therapies

phase i study results from an esophageal squamous cell carcinoma escc cohort treated with m7824 msb0011359c a bifunctional fusion protein targeting transforming growth factor β tgf β and pd l1

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m7824 msb0011359c a bifunctional fusion protein targeting pd l1 and tgf β in asian patients with pretreated biliary tract cancer preliminary results from a phase i trial

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m7824 msb0011359c a bifunctional fusion protein targeting pd l1 and tgf β in patients with post platinum esophageal adenocarcinoma eac preliminary results from a phase i cohort

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Nitrogen Fertilization and Harvest Management Improve Forage and Crude Protein Content in Crabgrass

Crabgrass (Digitaria spp.) is an annual summer grass that can provide high-quality forage, but optimal management strategies are unclear. Our objective was to compare the yield and quality of crabgrass (Mojo and Quick-N-Big) under different nitrogen rates and harvest management. The experimental design was a randomized complete block with five treatments and three replications for each crabgrass variety, totaling fifteen experimental units for both Mojo and Quick-N-Big, in adjacent sites. Treatments were nitrogen rates (0, 100, and 200 lb N/acre) and harvest management (cut once or twice per year) for two growing seasons (2020 and 2021). Total forage accumulation (TFA) increased with nitrogen fertilization for both cultivars. Mojo had the highest TFA in the first year (7000 lb DM/a/yr) while Quick-N-Big TFA was the highest in the second year (7635 lb DM/a/yr). The highest crude protein (CP) content was obtained with the highest N dose, ranging from 10.5 to 13% for both cultivars. Based on these results, N fertilization and harvest management can contribute to improving forage yield and crude protein of crabgrass varieties during the growing season in forage systems