Influence of the salinity adjustment methods, salts and brine, on the toxicity of wastewater samples to mussels embryos

One of the main problems of the Whole Effluent Toxicity is related to the use of bioindicator species representative of the target environment. Most wastewater discharges are of fresh water, so their salinity has to be adjusted when they are discharged to transitional and marine coastal waters, in order to perform toxicity bioassays with reliable organisms. At the moment, there is no optimum technique to allow sample salinity to be adjusted and no specific information regarding salinity adjustment when bivalves are being considered for toxicity test performance. This paper provides information on the potential use of different methods to adjust the salinity of hotel/domestic wastewater samples with different brands of natural and synthetic Dry Salts (DS) and HyperSaline Brine (HSB) for use in the embryo larval development bioassay with the mussel Mytilus galloprovincialis. HyperSaline Brine derived from reconstructed artificial seawater proved to be more viable for wastewater salinity adjustment than DS

Eastward Ho: Issues and Options in Regional Development for the Metropolitan Boston Region

Conventional wisdom suggests that the basic job of public policy studies (and public institutions, for that matter) is to deal in a timely and practical fashion with pressing public issues of the day. The focus typically is on \u27ripe\u27 topics, \u27hot\u27 political problems. If a study can be ahead of the curve, in John Kingdon\u27s apt phrase an idea whose time has come, so much the better. But unlike more traditional academic research, where the focus is timeless — i.e., an explanation of previously inexplicable phenomena, timeliness is a prime reason for initiating a policy study. In this context, analyzing the prospects for regional governance in Massachusetts and New England and suggesting the creation of any new arrangement for metropolitan regions for the Commonwealth seems premature or, at best, wishful thinking. But these are not conventional times. Wrenching changes in welfare, education, and health care are accelerating in a nation being demographically transformed. Three important forces are at work which suggest that regional goverment may be a timely topic after all. First, as we will describe, the academic community is giving some priority to the subject after two generations of neglect. Second, in a time of budgetary constraints, the economic development strategies of metropolitan communities increasingly require a global perspective that emphasizes the interdependence of central city and surrounding suburbs in achieving and maintaining an international competitive advantage. Especially in Massachusetts, given the effects of Proposition 2 1/2 and pressures on the costs of land and home ownership, the need to develop and articulate a common metropolitan economic strategy grows. Third, political forces speak increasingly to the ineffectiveness of local governments in coping with the critical issues of the day. In the midst of the Big Dig and a long-term inability to site a new convention center and a stadium within the metropolitan Boston region, how to plan and provide key metropolitan infrastructure is definitely a \u27hot\u27 political issue

CAR T-Cell Therapies in Italy: Patient Access Barriers and Recommendations for Health System Solutions

CAR T-cell therapy has emerged as a potentially transformative immunotherapy for certain B-cell malignancies including relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Unhindered and appropriate access for eligible patients is essential to enable optimal outcomes and depends on effective interplay of stakeholders and processes along the patient’s therapeutic journey. In Italy, CAR T-cell therapies have been awarded innovation status by the Italian Medicines Agency (AIFA) and were integrated into routine patient care under specific criteria. However, our analysis indicates that fewer than one in five DLBCL patients eligible under the EMA authorization, or around one in three DLBCL patients eligible under the AIFA criteria, received treatment with a licensed CAR T-cell therapy product in 2020. This publication describes key patient access barriers to CAR T-cell therapies in Italy and provides recommendations on potential solutions at the health system level

Fragrance materials (FMs) affect the larval development of the copepod Acartia tonsa: An emerging issue for marine ecosystems

Fragrance materials (FMs) are used in a variety of detergents and cosmetics, including household and personal care products. Despite their widespread use and the growing evidence of their occurrence in surface waters worldwide, very little is known about their toxicity towards marine species, including a key component of the marine food webs such as copepods. Thus, we investigated the toxicity of six of the more long-lasting and stable commercial fragrances, including Amyl Salicylate (AMY), Oranger Crystals (ORA), Hexyl Salicylate (HEX), Ambrofix (AMB), Peonile (PEO), and Benzyl Salicylate (BZS), to assess their ability to impair the larval development of the calanoid copepod Acartia tonsa. FMs inhibited the development of A. tonsa significantly at concentrations by far lower than the effect-concentrations reported in the literature for aquatic species. The more toxic FMs were HEX (EC50 = 57 ng L−1), AMY (EC50 = 131 ng L−1) and ORA (EC50 = 766 ng L−1), while the other three compounds exerted toxic effects at concentrations higher than 1000 ng L−1 (LOEC at 1000 ng L−1 for PEO and BZS, and at 10,000 ng L−1 for AMB). Early life-stage mortality was unaffected by FMs at all the tested concentrations. A comparison with water concentrations of FMs reported in the literature confirmed that FMs, especially HEX and AMY, may act as contaminants of potential concern in many aquatic habitats, including urban areas and remote and polar environments

Modelling the freezing and thawing behaviour of saturated soils

This thesis presents an investigation of the thermo / hydro / mechanical behaviour of saturated soils with cryogenic suction effects. The flow relationships accommodate a number of mechanisms: i) heat transfer by conduction, convection, and latent heat transfer and ii) moisture transfer in the liquid phase due to pressure head, elevation head, and thermal gradients. The mechanical behaviour of the soil is modelled by an elasto-plastic work hardening modified Cam- Clay constitutive model. A numerical solution for the theoretical formulation is presented. Standard finite element methods are used for spatial discretisation and finite difference methods are used for temporal discretisation. Verification of the model is achieved by means of programme of tests to check the following cryogenic components i) coupled thermo-hydraulic response, ii) deformation behaviour of the fully coupled thermo-hydro-mechanical model, iii) transient coupled liquid flow and deformation behaviour, and iv) latent heat of fusion. Validation focused on the impact of the cryogenic related processes included within the proposed theoretical formulation. In particular the development of ice lenses and the movement of moisture under cryogenic suction were investigated. The performance of the proposed model with respect to a number of variables was subsequently explored in order to determine their effect on the magnitude and growth of ice lenses in a freezing soil. The model was then applied to a large scale freezing experiment, namely a fully coupled thermo / hydro / mechanical simulation. The simulated results show a good correlation with the experimental results by predicting the patterns and trends of experimentally observed behaviour and the cryogenic processes that occur during the freezing and thawing of frost susceptible soils. It was therefore concluded that the proposed model is capable of providing a good representation of the fully coupled THM behaviour of saturated soils with cryogenic effects.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

X-ray analysis of JWST's first galaxy cluster lens SMACS J0723.3-7327

SMACS~J0723.3-7327 is the first galaxy cluster lens observed by JWST. Based on the ERO data from JWST, several groups have reported the results on strong lensing analysis and mass distribution of this cluster. However, limited by the angular coverage of the JWST data, the strong lensing models only cover the central region. X-ray analysis on the hot ICM is necessary to obtain a more complete constraint on the mass distribution in this very massive cluster. In this work, we aim to perform a comprehensive X-ray analysis of J0723 to obtain accurate ICM hydrostatic mass measurements, using the X-ray data from SRG/eROSITA and Chandra X-ray observatories. By comparing the hydrostatic mass profile with the strong lensing model, we aim to provide the most reliable constraint on the distribution of mass up to R500. Thanks to the eROSITA all-sky survey and Chandra data, which provide high S/N and high angular resolution respectively, we are able to constrain the ICM gas density profile and temperature profile with good accuracy both in the core and to the outskirts. With the density and temperature profiles, we compute the hydrostatic mass profile, which is then projected along the line of sight to compare with the mass distribution obtained from the recent strong lensing analysis based on JWST data. We also deproject the strong lensing mass distribution using the hydrostatic mass profile we obtained in this work. The X-ray results obtained from eROSITA and Chandra agree very well with each other. The hydrostatic mass profiles we measured in this work, both projected and deprojected, are in good agreement with recent strong lensing results based on JWST data, at all radii. We also find that the radial acceleration relation in J0723 is inconsistent with the RAR for spiral galaxies, implying that the latter is not a universal property of gravity across all mass scales.Comment: Accepted for publication in A&

Non-thermal pressure support in X-COP galaxy clusters

Galaxy clusters are the endpoints of structure formation and are continuously growing through the merging and accretion of smaller structures. Numerical simulations predict that a fraction of their energy content is not yet thermalized, mainly in the form of kinetic motions (turbulence, bulk motions). Measuring the level of non-thermal pressure support is necessary to understand the processes leading to the virialization of the gas within the potential well of the main halo and to calibrate the biases in hydrostatic mass estimates. We present high-quality measurements of hydrostatic masses and intracluster gas fraction out to the virial radius for a sample of 13 nearby clusters with available XMM-Newton and Planck data. We compare our hydrostatic gas fractions with the expected universal gas fraction to constrain the level of non-thermal pressure support. We find that hydrostatic masses require little correction and infer a median non-thermal pressure fraction of ∼6% and ∼10% at R500 and R200, respectively. Our values are lower than the expectations of hydrodynamical simulations, possibly implying a faster thermalization of the gas. If instead we use the mass calibration adopted by the Planck team, we find that the gas fraction of massive local systems implies a mass bias 1 − b = 0.85 ± 0.05 for Sunyaev– Zeldovich-derived masses, with some evidence for a mass-dependent bias. Conversely, the high bias required to match Planck cosmic microwave background and cluster count cosmology is excluded by the data at high significance, unless the most massive halos are missing a substantial fraction of their baryons

Tunable broadband light emission from graphene

Graphene is an ideal material for integrated nonlinear optics thanks to its strong light-matter interaction and large nonlinear optical susceptibility. Graphene has been used in optical modulators, saturable absorbers, nonlinear frequency converters, and broadband light emitters. For the latter application, a key requirement is the ability to control and engineer the emission wavelength and bandwidth, as well as the electronic temperature of graphene. Here, we demonstrate that the emission wavelength of graphene$'$ s broadband hot carrier photoluminescence can be tuned by integration on photonic cavities, while thermal management can be achieved by out-of-plane heat transfer to hexagonal boron nitride. Our results pave the way to graphene-based ultrafast broadband light emitters with tunable emission.Comment: 22 pages, 5 Figure