374 research outputs found

    Noisy quantum Monty Hall game

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    The influence of spontaneous emission channel and generalized Pauli channel on quantum Monty Hall Game is analysed. The scheme of Flittney and Abbott is reformulated using the formalism of density matrices. Optimal classical strategies for given quantum strategies are found. The whole presented scheme illustrates how quantum noise may change the odds of a zero-sum game.Comment: 10 pages, 3 figure

    Modelling Backward Travelling Holes in Mixed Traffic Conditions Using an Agent Based Simulation

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    A spatial queue model in a multi-agent simulation framework is extended by introducing a more realistic behaviour, i.e. backward travelling holes. Space corresponding to a leaving vehicle is not available immediately on the upstream end of the link. Instead, the space travels backward with a constant speed. This space is named a ‘hole’. The resulting dynamics resemble Newell’s simplified kinematic wave model. Furthermore, fundamental diagrams from homogeneous and heterogeneous traffic simulations are presented. The sensitivity of the presented approach is tested with the help of flow density contours

    Extending scientific computing system with structural quantum programming capabilities

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    We present a basic high-level structures used for developing quantum programming languages. The presented structures are commonly used in many existing quantum programming languages and we use quantum pseudo-code based on QCL quantum programming language to describe them. We also present the implementation of introduced structures in GNU Octave language for scientific computing. Procedures used in the implementation are available as a package quantum-octave, providing a library of functions, which facilitates the simulation of quantum computing. This package allows also to incorporate high-level programming concepts into the simulation in GNU Octave and Matlab. As such it connects features unique for high-level quantum programming languages, with the full palette of efficient computational routines commonly available in modern scientific computing systems. To present the major features of the described package we provide the implementation of selected quantum algorithms. We also show how quantum errors can be taken into account during the simulation of quantum algorithms using quantum-octave package. This is possible thanks to the ability to operate on density matrices

    Targeting the Ets Binding Site of the HER2/neu Promoter with Pyrrole-Imidazole Polyamides

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    Three DNA binding polyamides (1-3) were synthesized that bind with high affinity (Ka = 8.7·10^9 M^-1 to 1.4·10^10 M^-1) to two 7-base pair sequences overlapping the Ets DNA binding site (EBS; GAGGAA) within the regulatory region of the HER2/neu proximal promoter. As measured by electrophoretic mobility shift assay, polyamides binding to flanking elements upstream (1) or downstream (2 and 3) of the EBS were one to two orders of magnitude more effective than the natural product distamycin at inhibiting formation of complexes between the purified EBS protein, epithelial restricted with serine box (ESX), and the HER2/neu promoter probe. One polyamide, 2, completely blocked Ets-DNA complex formation at 10 nM ligand concentration, whereas formation of activator protein-2-DNA complexes was unaffected at the activator protein-2 binding site immediately upstream of the HER2/neu EBS, even at 100 nM ligand concentration. At equilibrium, polyamide 1 was equally effective at inhibiting Ets/DNA binding when added before or after in vitro formation of protein-promoter complexes, demonstrating its utility to disrupt endogenous Ets-mediated HER2/neu preinitiation complexes. Polyamide 2, the most potent inhibitor of Ets-DNA complex formation by electrophoretic mobility shift assay, was also the most effective inhibitor of HER2/neu promoter-driven transcription measured in a cell-free system using nuclear extract from an ESX- and HER2/neu-overexpressing human breast cancer cell line, SKBR-3

    Inclusive production of J/ψJ/\psi meson in proton-proton collisions at BNL RHIC

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    Inclusive cross sections for J/ψJ/\psi production in proton-proton collisions were calculated in the ktk_t-factorization approach for the RHIC energy. Several mechanisms were considered, including direct color-singlet mechanism, radiative decays of χc\chi_c mesons, decays of ψ′\psi', open-charm associated production of J/ψJ/\psi as well as weak decays of B mesons. Different unintegrated gluon distributions from the literature were used. We find that radiative χc\chi_c decays and direct color-singlet contributions constitute the dominant mechanism of J/ψJ/\psi production. These process cannot be consistently treated within collinear-factorization approach. The results are compared with recent RHIC data. The new precise data at small transverse momenta impose stringent constraints on UGDFs. Some UGDFs are inconsistent with the new data. The Kwieci\'nski UGDFs give the best description of the data. In order to verify the mechanism suggested here we propose J/ψJ/\psi -- jet correlation measurement and an independent measurement of χc\chi_c meson production in π+π−\pi^+ \pi^- and/or K+K−K^+ K^- decay channels. Finally, we address the issue of \J spin alignment.Comment: 26 pages, 20 figures, the text was slightly modified, the title was modified, more discussion was added, one figure was removed, one was adde

    Dijet correlations at RHIC, leading-order ktk_t-factorization approach versus next-to-leading order collinear approach

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    We compare results of ktk_t-factorization approach and next-to-leading order collinear-factorization approach for dijet correlations in proton-proton collisions at RHIC energies. We discuss correlations in azimuthal angle as well as correlations in two-dimensional space of transverse momenta of two jets. Some ktk_t-factorization subprocesses are included for the first time in the literature. Different unintegrated gluon/parton distributions are used in the ktk_t-factorization approach. The results depend on UGDF/UPDF used. For collinear NLO case the situation depends significantly on whether we consider correlations of any two jets or correlations of leading jets only. In the first case the 2→22 \to 2 contributions associated with soft radiations summed up in the ktk_t-factorization approach dominate at ϕ∼π\phi \sim \pi and at equal moduli of jet transverse momenta. The collinear NLO 2→32 \to 3 contributions dominate over ktk_t-factorization cross section at small relative azimuthal angles as well as for asymmetric transverse momentum configurations. In the second case the NLO contributions vanish at small relative azimuthal angles and/or large jet transverse-momentum disbalance due to simple kinematical constraints. There are no such limitations for the ktk_t-factorization approach. All this makes the two approaches rather complementary. The role of several cuts is discussed and quantified.Comment: 26 pages, 17 figure

    Kinetics of Cleavage of Intra- and Extracellular Simian Virus 40 DNA with the Enediyne Anticancer Drug C- 1027

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    A kinetic analysis of cleavage of simian virus DNA (SV40 DNA) inside and outside green monkey BSC-I cells by the enediyne-protein antibiotic C-1027 and its free chromophore is described. Information on rate constants was obtained by fitting populations of forms I (closed circular DNA), II (nicked circular DNA) and III (linear DNA) of SV4f.J DNA as a function of drug concentration to a kinetic model which includes: cutting of form I to give form II with rate constant k1. cutting of form I to give form III with rate constant k4, and cutting of form II to give form III with rate constant k2. Theratio of single-strand (ss) to double-strand (ds) cutting for the holoantibiotic and the free chromophore. k1/k4, is approximately 1.8 for extracellular SV40 DNA. For intracellular DNA and extracellular DNA which has been post-treated with putrescine, ds cutting is much more probable, with k4, about four times as large as k1. This observation suggests that amine groups present in the cell are able to convert abasic sites opposite an ss break into a ds break in SV40 chkomatin. The overall rate of cleavage of form-1 DNA inside the cell is much larger than the rate outside, the sum k1 + k4 being about three times as large for intracellular DNA as for extracellular DNA

    Scaling-up beginning farmers for wholesale production

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    With nearly 15 million people that live within 250 miles of Kansas City, the demand for local food is increasing. Local beginning farmers in the region want to reach an emerging wholesale market. However, selling directly to consumers demands different skills than the wholesale market requires. There are many educational programs offered in the region that are focused on direct to consumer sales. Unfortunately, there is a gap in educational programs that are offered to support beginning farmers that wish to expand into wholesale markets. In 2018, the Beginning Farmer Wholesale Project was started within the Growing Growers Kansas City program in congruence with the overall mission to improve the skills and livelihoods of the region’s growers. The project offers support and training to beginning farmers as they begin to navigate new market opportunities. It provides on-farm technical assistance, mentorship, opportunities to connect to wholesale buyers, a workshop series, a manual and an extensive foodshed GIS map. The ongoing project has seen several contributions to improving farmer access to wholesale markets. As of 2020, six workshops have been conducted that have covered a variety of farm production and marketing skills. Six farmer mentees have enrolled in the mentor program which enlists nine farmer mentors from across the region. Over twenty farmers have utilized the technical assistance service on their Kansas and Missouri farm operations and the farmer buyer matching program has resulted in thirteen beginning farmers gaining access to new markets. The project highlights the value of collaboration among organizations and the importance of offering multiple farmer services in order to improve wholesale access

    A Simplified Cellular Automaton Model for City Traffic

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    We systematically investigate the effect of blockage sites in a cellular automaton model for traffic flow. Different scheduling schemes for the blockage sites are considered. None of them returns a linear relationship between the fraction of ``green'' time and the throughput. We use this information for a fast implementation of traffic in Dallas.Comment: 12 pages, 18 figures. submitted to Phys Rev

    Properties of pig heart aconitase

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