Optimizing ride-sharing operations in smart sustainable cities: Challenges and the need for agile algorithms

[EN] Mobility solutions like ride-sharing and carpooling are becoming popular in many urban and metropolitan areas around the globe. These solutions, however, create many operational challenges that need to be solved in order to make them more efficient and sustainable in time, e.g.: determining the number and location of parking slots, finding the optimal routes in terms of time or emissions, or developing synchronized schedules among ride-sharing users. This paper provides an updated review on car-sharing optimization studies (including ride-sharing and carpooling), compares different analytical approaches in this research area, and discusses the emerging concept of 'agile' algorithms as one of the approaches that might contribute to deal with the requirements of large-scale and dynamic car-sharing optimization problems.Do C. Martins, L.; Torre-Martínez, MRDL.; Corlu, CG.; Juan, AA.; Masmoudi, MA. (2021). Optimizing ride-sharing operations in smart sustainable cities: Challenges and the need for agile algorithms. Computers & Industrial Engineering. 153:1-17. https://doi.org/10.1016/j.cie.2020.10708011715

Tissue distribution of liver regulating protein. Evidence for a cell recognition signal common to liver, pancreas, gonads, and hemopoietic tissues.

Liver regulating protein (LRP) is an integral plasma membrane protein that plays a critical role in maintaining the differentiated phenotype of adult rat hepatocytes by mediating cell-cell interactions with rat liver epithelial cells. Using a specific monoclonal antibody (MAb L8) capable of inhibiting the interactions between these two cell types, the cellular distribution of LRP was analyzed in the liver. Various cell types, including hepatocytes and several sinusoidal cells, were found to be positive, whereas vascular endothelial cells and bile duct cells were consistently negative. This observation led us to question whether cells of nonhepatic origin would also express LRP. We show that MAb L8 immunoreactive material was detected in only three groups of tissues and corresponded to molecules similar to LRP but with different molecular weights. LRP-like molecules were demonstrated on acinar cells of the exocrine pancreas and on all hemopoietic cells regardless of their localization in the organism. LRP-like molecules were also expressed by germ cells and surrounding feeder cells in the testis and ovary in a stage-dependent manner. These results demonstrate the existence of a family of LRP proteins and strongly suggest a critical role for these molecules in regulating cell-cell communication in specific tissues