Bengamides and related new amino acid derivatives from the New Caledonian marine sponge Jaspis carteri

Five new amino acid derivs. were isolated from the New Caledonian sponge Jaspis carteri, together with known bengamides A and B. The structures of the new compds. were detd. by interpretation of their spectral data and by comparison with spectral data of known bengamides. Bengamides G (I), and H, I, and J are simply the tridecanoate and pentadecanoate analogs of the original bengamides A and B, whereas bengamide K (II) is a caprolactam formamide deriv. of bengamide B

Bengamides and Related New Amino Acid Derivatives from the New Caledonian Marine SpongeJaspis carteri

Five new amine acid derivatives were isolated from the New Caledonian sponge Jaspis carteri, together with known bengamides A and B. The structures of the new compounds were determined by interpretation of their spectral data and by comparison with spectral data of known bengamides. Compounds 4-7 are simply the tridecanoate and pentadecanoate analogues of the original bengamides A and B, whereas compound 8 is a caprolactam formamide derivative of bengamide B

Synthesis and Properties of Polymeric Schiff-Bases and Their CO(II), CU(II) and NI(II) Complexes

Soluble and insoluble polymeric Schiff bases PolySalPn and PolySal-DPT* have been synthesised. The polymers and their copper(II), nickel(II) and cobalt(II) complexes have been fully characterised by their elemental analyses and by spectroscopic methods. The Co—PolySalDPT proved to be as efficient as the corresponding monomeric complex in catalysing the oxidation of 2,6-di-t-butylphenol

Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.

As part of our search for new antimalarial drugs, we have screened for inhibitors of Pfnek-1, a protein kinase of Plasmodium falciparum, in south Pacific marine sponges. On the basis of a preliminary screening, the ethanolic crude extract of a new species of Xestospongia collected in Vanuatu was selected for its promising activity. A bioassay-guided fractionation led us to isolate xestoquinone which inhibits Pfnek-1 with an IC50 around 1 mu M. Among a small panel of plasmodial protein kinases, xestoquinone showed modest protein kinase inhibitory activity toward PfPK5 and no activity toward PfPK7 and PfGSK-3. Xestoquinone showed in vitro antiplasmodial activity against a FCB1 P. falciparum strain with an IC50 of 3 mu M and a weak selectivity index (SI 7). Xestoquinone exhibited a weak in vivo activity at 5 mg/kg in Plasmodium berghei NK65 infected mice and was toxic at higher doses. (c) 2006 Elsevier Ltd. All rights reserved