CONTRIBUTION OF FORMAL FINANCIAL INSTITUTIONS TO CASSAVA PROCESSING IN BENUE STATE, NIGERIA

The study was carried out to assess the contribution of Formal Financial Institutions (FFIs) to income of cassava processors in Benue state, Nigeria. Multistage sampling technique was used to select 234 cassava processors from 18 communities in the state. Data on credit sources and uses, processing activities and income were collected using structured questionnaires. The data were analyzed using descriptive and inferential statistics while the impact of the credit was assessed using the before and after comparison. The result shows that about a third of the processors had access to formal credits. The Nigerian Agricultural Bank ranked highest (83%) in terms of patronage. Commercial and microfi-nance banks«¤?? lending to cassava processing represented about 12% and 5% respectively of the total credit received. Majority (70%) of the processors received less than N100, 000 per year; an average of N63,152, which is about 12% of total amount, required. Credit financing from formal financial institu-tions was found to have significant effects on both the output of garri and flour processed and the profit from garri, flour and chips«¤?? processing. The credit use structure shows that over 65% of the credit was use to increase processing scale, through increase in the purchase of raw tubers and payment for processing labour

CONTRIBUTION OF FORMAL FINANCIAL INSTITUTIONS TO CASSAVA PROCESSING IN BENUE STATE, NIGERIA

The study was carried out to assess the contribution of Formal Financial Institutions (FFIs) to income of cassava processors in Benue state, Nigeria. Multistage sampling technique was used to select 234 cassava processors from 18 communities in the state. Data on credit sources and uses, processing activities and income were collected using structured questionnaires. The data were analyzed using descriptive and inferential statistics while the impact of the credit was assessed using the before and after comparison. The result shows that about a third of the processors had access to formal credits. The Nigerian agricultural bank ranked highest (83%) in terms of patronage. Commercial and microfinance banks’ lending to cassava processing represented about 12% and 5% respectively of the total credit received. Majority (70%) of the processors received less than N100, 000 per year; an average of N63,152, which is about 12% of total amount, required. Credit financing from formal financial institutions was found to have significant effects on both the output of garri and flour processed and the profit from garri, flour and chips’ processing. The credit use structure shows that over 65% of the credit was use to increase processing scale, through increase in the purchase of raw tubers and payment for processing labour

Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery

Reactive nitrogen species (RNS) play important roles in mediating cerebral ischemia-reperfusion injury. RNS activate multiple signaling pathways and participate in different cellular events in cerebral ischemia-reperfusion injury. Recent studies have indicated that caveolin-1 and matrix metalloproteinase (MMP) are important signaling molecules in the pathological process of ischemic brain injury. During cerebral ischemia-reperfusion, the production of nitric oxide (NO) and peroxynitrite (ONOO-), two representative RNS, down-regulates the expression of caveolin-1 (Cav-1) and, in turn, further activates nitric oxide synthase (NOS) to promote RNS generation. The increased RNS further induce MMP activation and mediate disruption of the blood-brain barrier (BBB), aggravating the brain damage in cerebral ischemia-reperfusion injury. Therefore, the feedback interaction among RNS/Cav-1/MMPs provides an amplified mechanism for aggravating ischemic brain damage during cerebral ischemia-reperfusion injury. Targeting the RNS/Cav-1/MMP pathway could be a promising therapeutic strategy for protecting against cerebral ischemia-reperfusion injury. In this mini-review article, we highlight the important role of the RNS/Cav-1/MMP signaling cascades in ischemic stroke injury and review the current progress of studies seeking therapeutic compounds targeting the RNS/Cav-1/MMP signaling cascades to attenuate cerebral ischemia-reperfusion injury. Several representative natural compounds, including calycosin-7-O-β-D-glucoside, baicalin, Momordica charantia polysaccharide (MCP), chlorogenic acid, lutein and lycopene, have shown potential for targeting the RNS/Cav-1/MMP signaling pathway to protect the brain in ischemic stroke. Therefore, the RNS/Cav-1/MMP pathway is an important therapeutic target in ischemic stroke treatment.published_or_final_versio

Secondary stroke prevention: challenges and solutions

Charles Esenwa, Jose GutierrezDepartment of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USAAbstract: Stroke is the leading cause of disability in the USA and a major cause of mortality worldwide. One out of four strokes is recurrent. Secondary stroke prevention starts with deciphering the most likely stroke mechanism. In general, one of the main goals in stroke reduction is to control vascular risk factors such as hypertension, diabetes, dyslipidemia, and smoking cessation. Changes in lifestyle like a healthy diet and aerobic exercise are also recommended strategies. In the case of cardioembolism due to atrial fibrillation, mechanical valves, or cardiac thrombus, anticoagulation is the mainstay of therapy. The role of anticoagulation is less evident in the case of bioprosthetic valves, patent foramen ovale, and dilated cardiomyopathy with low ejection fraction. Strokes due to larger artery atherosclerosis account for approximately a third of all strokes. In the case of symptomatic extracranial carotid stenosis, surgical intervention as close as possible in time to the index event seems highly beneficial. In the case of intracranial large artery atherosclerosis, the best medical therapy consists of antiplatelets, high-dose statins, aggressive controls of vascular risk factors, and lifestyle modifications, with no role for intracranial arterial stenting or angioplasty. For patients with small artery occlusion (ie, lacunar stroke), the therapy is similar to that used in patients with intracranial large artery atherosclerosis. Despite the constant new evidence on how to best treat patients who have suffered a stroke, the risk of stroke recurrence remains unacceptably high, thus evidencing the need for novel therapies.Keywords: stroke mechanisms, stroke risk, hypertension, diabetes, dyslipidemi

A summary of the body of knowledge on physical activity for people following stroke. A protocol for a scoping review

Background: The cause of low levels of physical activity (PA) in the post stroke population is complex and multifactorial. The volume of research in the area of physical activity and stroke is vast, coupled with complexities with respect to definitions of physical activity. The current UK clinical guidelines (National Institute of Care and Excellence NICE 2013 and Royal College of Physicians RCP 2016) are broad in their advice with respect to implementation strategy dimensions* across the stroke pathway of care**. In response, our aim for this scoping review is to gain an overview of the evidence, describing the focus in relation to population demographics*** across the stroke pathway of care and the implementation strategy dimensions being utilised in physical activity interventions. * Implementation strategy dimensions extracted in this scoping review include physical activity specific dimensions (mode, frequency, duration, intensity), domains (occupational, domestic, transport, leisure time) and provider (who delivers the intervention). ** Stroke pathway of care refers to the setting in which the intervention occurred (e.g. acute care, primary health care or community). ***Population demographics include severity of stroke, physical or cognitive impairment level, gender, classification of stroke; acute, subacute, chronic and variation of time since onset of stroke Methods and analysis: This scoping review protocol is registered with the Open Science Framework (https://osf.io/vjfp4). The review will follow Arksey and O’Malley scoping review methodology. The search will include relevant systematic reviews from a range of electronic databases, followed by title and abstract screening as well as a full text review. All review steps will involve two or more reviewers. Data extraction, charting and summary will be guided by a template aligned to the study objectives. Findings will be presented in tabular format and will include a descriptive numerical summary as well as a descriptive overview. Ethics and dissemination: Findings will be disseminated through a peer-reviewed journal, conference presentations and as part of future workshops and events with professionals involved in physical activity and stroke. The scoping review does not require ethics approval. </p